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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Transient receptor potential cation channel, subfamily A, member 1a

TRPA1, trpa1a
Top mentioned proteins: TRPV1, TRPM8, CAN, V1a, ACID
Papers using TRPA1 antibodies
Physiological roles of TRPV2 expressed in the olfactory axon
Hirakawa Katsuhiro et al., In Acta Oto-Laryngologica, 2006
... rabbit polyclonal antibody to TRPM8 (Osenses Ltd) (diluted 1:300), or with a rabbit polyclonal antibody to TRPA1 (Transgenic) (diluted 1:200) in 0.3% ...
Papers on TRPA1
Proton-gated Ca(2+)-permeable TRP channels damage myelin in conditions mimicking ischaemia.
Attwell et al., London, United Kingdom. In Nature, Feb 2016
The H(+)-gated [Ca(2+)]i elevation is mediated by channels with characteristics of TRPA1, being inhibited by ruthenium red, isopentenyl pyrophosphate, HC-030031, A967079 or TRPA1 knockout.
TRPing on the pore phenomenon: what do we know about transient receptor potential ion channel-related pore dilation up to now?
Faria et al., Rio de Janeiro, Brazil. In J Bioenerg Biomembr, Feb 2016
The TRPA1, TRPM8, and TRPV1-4 subtypes have been shown to promote large-molecular-weight solute uptake, including impermeable fluorescent dyes, QX-314 hydrophilic lidocaine derivative, gabapentin, and antineoplastic drugs.
An Unexpected Role for TRPV4 in Serotonin-Mediated Itch.
Ross et al., Pittsburgh, United States. In J Invest Dermatol, Jan 2016
Previous studies have revealed that TRPV1 and TRPA1 function downstream of many itch receptors, where they mediate inward current to trigger action potentials in primary afferents.
TRPA1 channels as targets for resveratrol and related stilbenoids.
De Petrocellis et al., Roma, Italy. In Bioorg Med Chem Lett, Jan 2016
UNASSIGNED: A series of twenty resveratrol analogues was synthesized and tested on TRPA1 and TRPV1 channels.
TRP channel mediated neuronal activation and ablation in freely behaving zebrafish.
Prober et al., Pasadena, United States. In Nat Methods, Jan 2016
We exploit these properties by using transient receptor potential (TRP) channels to activate or ablate specific neuronal populations using the chemical and thermal agonists of heterologously expressed TRPV1, TRPM8 and TRPA1.
Migraine Triggers and Oxidative Stress: A Narrative Review and Synthesis.
Borkum, United States. In Headache, Jan 2016
The recent discovery that the TRPA1 ion channel transduces oxidative stress and triggers neurogenic inflammation suggests that oxidative stress may be the common denominator underlying migraine triggers.
Transient receptor potential ankyrin 1 (TRPA1) receptor is involved in chronic arthritis: in vivo study using TRPA1-deficient mice.
Helyes et al., Pécs, Hungary. In Arthritis Res Ther, Dec 2015
BACKGROUND: The transient receptor potential ankyrin 1 (TRPA1) is a calcium-permeable cation channel that is expressed on capsaicin-sensitive sensory neurons, endothelial and inflammatory cells.
Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner.
Brain et al., São Luís, Brazil. In Arthritis Res Ther, Dec 2015
The aim of this study was to investigate how environmental cold affects pain and blood flow in mono-arthritic mice, and examine a role for transient receptor potential ankyrin 1 (TRPA1), a ligand-gated cation channel that can act as a cold sensor.
Transient Receptor Potential Channels and Corneal Stromal Inflammation.
Saika et al., Wakayama, Japan. In Cornea, Nov 2015
In this review, we specifically focus on the functional roles of TRPV1 and TRPA1 expression in the cornea as their activation provides adaptive nociceptive and immune responses to noxious environmental stresses such as irritating ligands, temperature fluctuations, rises in ambient osmolarity, mechanical stretch, decline in pH, and tissue injury.
TRP channel functions in the gastrointestinal tract.
Yu et al., Baltimore, United States. In Semin Immunopathol, Nov 2015
In this review, we focus on the expressions and functions of TRPV1, TRPA1, and TRPM8 in primary extrinsic afferent nerves innervated in the esophagus, stomach, intestine, and colon and briefly discuss their potential roles in relevant GI disorders.
Structure of the TRPA1 ion channel suggests regulatory mechanisms.
Julius et al., San Francisco, United States. In Nature, May 2015
The TRPA1 ion channel (also known as the wasabi receptor) is a detector of noxious chemical agents encountered in our environment or produced endogenously during tissue injury or drug metabolism.
TRP Channels in Respiratory Pathophysiology: the Role of Oxidative, Chemical Irritant and Temperature Stimuli.
Zholos, Kiev, Ukraine. In Curr Neuropharmacol, 2014
Several of these channels, such as TRPM2, TRPM8, TRPA1 and TRPV1, are discussed in much detail to show that they perform diverse, and often overlapping or contributory, roles in airway hyperreactivity, inflammation, asthma, chronic obstructive pulmonary disease and other respiratory disorders.
Deciphering Subtype-Selective Modulations in TRPA1 Biosensor Channels.
Mori et al., Kyoto, Japan. In Curr Neuropharmacol, 2014
Among them, TRPA1 is remarkably susceptible to various oxidants, and is known to mediate neuropathic pain and respiratory, vascular and gastrointestinal functions, making TRPA1 an attractive therapeutic target.
Painful and painless channelopathies.
Woods et al., Cambridge, United Kingdom. In Lancet Neurol, 2014
Heterozygous mutations in TRPA1, which encodes the transient receptor potential cation channel, can cause familial episodic pain syndromes, and variants of genes coding for the voltage-gated sodium channels Nav1.8 (SCN10A) and Nav1.9 (SCN11A) lead to small-fibre neuropathy and congenital insensitivity to pain, respectively.
The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch.
Bautista et al., Berkeley, United States. In Cell, 2013
TSLP then acts directly on a subset of TRPA1-positive sensory neurons to trigger robust itch behaviors.
Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function.
Schier et al., Cambridge, United States. In J Neurosci, 2008
Larvae heterozygous for mutations in trpa1a respond to mustard oil to an extent similar to that of their wild-type siblings.
TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells.
Zhang et al., Boston, United States. In Nature, 2005
Inhibition of TRPA1 protein expression in zebrafish and mouse inner ears inhibits receptor cell function
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