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Transient receptor potential cation channel, subfamily M, member 2

Trp7, TRPM2, TRPC7
The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: melastatin, V1a, CAN, TRPC3, Trp6
Papers on Trp7
Screening of TRPC Channel Activators Identifies Novel Neurotrophic Piperazine Compounds.
New
Mori et al., Kyoto, Japan. In Mol Pharmacol, Feb 2016
We discovered, through library screening, a group of piperazine-derived compounds that activate DAG-activated TRPC3/TRPC6/TRPC7 channels.
Data-driven Analysis of TRP Channels in Cancer: Linking Variation in Gene Expression to Clinical Significance.
New
Shin et al., Seoul, South Korea. In Cancer Genomics Proteomics, Feb 2016
RESULTS: TRPM2 was found overexpressed in most tumors, whereas TRPM3 was broadly down-regulated.
Detrimental or beneficial: the role of TRPM2 in ischemia/reperfusion injury.
Review
New
Yang et al., Hangzhou, China. In Acta Pharmacol Sin, Jan 2016
Recent evidence demonstrates that TRPM2, a Ca(2+)-permeable cationic channel and ROS sensor, is involved in I/R injury, but whether TRPM2 plays a protective or detrimental role in this process remains controversial.
Francisella tularensis catalase restricts immune function by impairing TRPM2 channel activity.
New
Melendez et al., New York City, United States. In J Biol Chem, Jan 2016
Indeed, increases in basal Ca2+, actin polymerization and IL-6 production are reversed in TRPM2-null macrophages infected with ΔkatG.
Somato-axodendritic release of oxytocin into the brain due to calcium amplification is essential for social memory.
Review
New
Higashida, Kanazawa, Japan. In J Physiol Sci, Dec 2015
In addition, it has recently been reported that heat stimulation and hyperthermia enhance [Ca(2+)] i increases by Ca(2+) influx, probably through TRPM2 cation channels, suggesting that cADPR and TRPM2 molecules act as Ca(2+) signal amplifiers.
Clinical prospects of long noncoding RNAs as novel biomarkers and therapeutic targets in prostate cancer.
Review
New
Perera et al., United States. In Prostate Cancer Prostatic Dis, Nov 2015
lncRNAs including PCA3, PCATs, SChLAP1, SPRY4-IT1 and TRPM2-AS are upregulated in PCa and are cancer specific; they are, therefore, attractive lead candidate biomarkers for clinical application.
Decreased levels of canonical transient receptor potential channel 3 protein in the rat cerebral cortex after chronic treatment with lithium or valproate.
New
Emamghoreishi et al., Shīrāz, Iran. In Res Pharm Sci, Sep 2015
TRPC3 and TRPM2, are potential candidates involved in calcium signaling and implicated in the pathophysiology of bipolar disorder.
A dual role of transient receptor potential melastatin 2 channel in cytotoxicity induced by silica nanoparticles.
Yang et al., Hangzhou, China. In Sci Rep, 2014
Transient receptor potential melastatin 2 (TRPM2) channel is known to be a cellular redox potential sensor that provides an important pathway for increasing the [Ca(2+)]i under oxidative stress.
TRP Channels in Respiratory Pathophysiology: the Role of Oxidative, Chemical Irritant and Temperature Stimuli.
Review
Zholos, Kiev, Ukraine. In Curr Neuropharmacol, 2014
Several of these channels, such as TRPM2, TRPM8, TRPA1 and TRPV1, are discussed in much detail to show that they perform diverse, and often overlapping or contributory, roles in airway hyperreactivity, inflammation, asthma, chronic obstructive pulmonary disease and other respiratory disorders.
Psychiatric Disorders and TRP Channels: Focus on Psychotropic Drugs.
Review
Demirdaş et al., Isparta, Turkey. In Curr Neuropharmacol, 2014
Intracellular calcium influx induced by oxidative stress has an significant role in the etiology of bipolar disorders (BDs), and studies recently reported the important role of TRP channels such as TRPC3, TRPM2, and TRPV1 in converting oxidant or nitrogen radical signaling to cytosolic calcium ion homeostasis in BDs.
Divalent copper is a potent extracellular blocker for TRPM2 channel.
GeneRIF
Xu et al., Kingston upon Hull, United Kingdom. In Biochem Biophys Res Commun, 2012
Cu2+ is a potent TRPM2 channel blocker. The sensitivity of TRPM2 channel to heavy metal ions could be a new mechanism for the pathogenesis of some metal ion-related diseases.
NAD+ levels control Ca2+ store replenishment and mitogen-induced increase of cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes.
GeneRIF
Bruzzone et al., Genova, Italy. In J Biol Chem, 2012
the changes of Ca(2+) homeostasis induced by NAD(+) precursors are mediated by CD38 and the consequent ADPR-mediated TRPM2 gating.
Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions.
GeneRIF
Tominaga et al., Okazaki, Japan. In Proc Natl Acad Sci U S A, 2012
findings suggest that redox signals sensitize TRPM2 downstream of NADPH oxidase activity and make TRPM2 active at physiological body temperature, leading to increased cytosolic Ca(2+) concentrations
The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation.
Impact
Malik et al., Chicago, United States. In Nat Immunol, 2012
Here we report that TRPM2, a nonselective and redox-sensitive cation channel, inhibited ROS production in phagocytic cells and prevented endotoxin-induced lung inflammation in mice.
The ion channel transient receptor potential melastatin-2 does not play a role in inflammatory mouse models of chronic obstructive pulmonary diseases.
GeneRIF
Trifilieff et al., Basel, Switzerland. In Respir Res, 2011
The ion channel transient receptor potential melastatin-2 does not play a role in inflammatory mouse models of chronic obstructive pulmonary diseases.
Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons.
GeneRIF
Jackson et al., London, Canada. In Mol Brain, 2011
Glutathione plays a physiologically relevant role in the regulation of TRPM2 currents in hippocampal pyramidal neurons.
Melanopsin signalling in mammalian iris and retina.
Impact
Yau et al., Baltimore, United States. In Nature, 2011
Ablating in mouse the expression of both TRPC6 and TRPC7, members of the TRP channel superfamily, also essentially eliminated the M1-ipRGC light response but the intrinsic PLR was not affected.
TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration.
Impact
Mori et al., Kyoto, Japan. In Nat Med, 2008
Here we show that the plasma membrane Ca(2+)-permeable channel TRPM2 controls ROS-induced chemokine production in monocytes.
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels.
Impact
Muallem et al., Dallas, United States. In Nat Cell Biol, 2007
TRPC7 is not regulated by STIM1.
ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology.
Impact
Scharenberg et al., Boston, United States. In Nature, 2001
Here we show that a 350-amino-acid protein (designated NUDT9) and a homologous domain (NUDT9 homology domain) near the carboxy terminus of the LTRPC2/TrpC7 putative cation channel both function as specific ADPR pyrophosphatases.
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