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Dopachrome tautomerase

TRP-2, dopachrome tautomerase, tyrosinase-related protein 2
RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: tyrosinase, TRPC1, CAN, ACID, Microphthalmia-Associated Transcription Factor
Papers on TRP-2
Interleukin-21 administration to aged mice rejuvenates their peripheral T-cell pool by triggering de novo thymopoiesis.
New
Rafei et al., Montréal, Canada. In Aging Cell, Feb 2016
Consequently, aged rIL-21-treated mice vaccinated using a tyrosinase-related protein 2 (Trp2)-derived peptide exhibited a substantial delay in B16 tumor growth and improved survival.
Simultaneous quantitative analysis of 12 methoxyflavones with melanogenesis inhibitory activity from the rhizomes of Kaempferia parviflora.
New
Morikawa et al., Ōsaka, Japan. In J Nat Med, Jan 2016
Compounds 6, 7, 12, and 13 inhibited the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA, which could be the mechanism of their melanogenesis inhibitory activity.
Circulating melanoma exosomes as diagnostic and prognosis biomarkers.
New
González et al., Spain. In Clin Chim Acta, Jan 2016
The aim of this study was to identify and evaluate the presence of the melanoma biomarkers MIA, S100B and tyrosinase-related protein 2 (TYRP2) in exosomes and their potential clinical utility.
Surface display of glycosylated Tyrosinase related protein-2 (TRP-2) tumour antigen on Lactococcus lactis.
Yusoff et al., Kuala Selangor, Malaysia. In Bmc Biotechnol, 2014
In this study, the glycosylated murine Tyrosinase related protein-2 (TRP-2) with the ability to anchor onto the L. lactis cell wall was produced in suspension adapted Chinese Hamster Ovary (CHO-S) cells by expressing TRP-2 fused with cell wall anchoring LysM motif (cA) at the C-terminus.
The macrophage migration inhibitory factor protein superfamily in obesity and wound repair.
Review
Bucala et al., New Haven, United States. In Exp Mol Med, 2014
The macrophage migration inhibitory factor (MIF) superfamily consists of MIF and the recently identified homolog D-dopachrome tautomerase (D-DT or MIF-2).
Stromal-dependent tumor promotion by MIF family members.
Review
Yaddanapudi et al., Louisville, United States. In Cell Signal, 2014
One family of soluble factors that is becoming increasingly associated with pro-tumoral phenotypes within tumor microenvironments is that of the migration inhibitory factor family which includes its namesake, MIF, and its only known family member, D-dopachrome tautomerase (D-DT).
CD74 in Kidney Disease.
Review
Sanchez-Niño et al., Madrid, Spain. In Front Immunol, 2014
CD74 (invariant MHC class II) regulates protein trafficking and is a receptor for macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT/MIF-2).
Whitening Effect of Watersoluble Royal Jelly from South Korea.
Pak et al., South Korea. In Korean J Food Sci Anim Resour, 2014
In addition, we investigated the mRNA and protein expression of melanogenesis-related genes such as tyrosinase, tyrosinase related protein-1 (TRP-1) and TRP-2 by reverse transcription-polymerase chain reaction and western blotting.
Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors.
Review
Ochs et al., Heidelberg, Germany. In Front Immunol, 2013
A plethora of preclinical models suggests that this immune tolerance pathway - driven by the key and rate-limiting enzymes indoleamine-2,3-dioxygenase and TRP-2,3-dioxygenase - is active in cancer immunity, autoimmunity, infection, transplant rejection, and allergy.
Age-induced hair greying - the multiple effects of oxidative stress.
Review
Seiberg, Princeton, United States. In Int J Cosmet Sci, 2013
With ageing, the bulbar melanocyte expression of anti-oxidant proteins such as BCL-2, and possibly TRP-2, is reduced, and the dedicated enzymatic anti-oxidant defence system throughout the follicle weakens, resulting in enhanced oxidative stress.
SWI/SNF protein component BAF250a regulates cardiac progenitor cell differentiation by modulating chromatin accessibility during second heart field development.
GeneRIF
Wang et al., Boston, United States. In J Biol Chem, 2012
Results thus identify BAF250a-mediated chromatin remodeling as an essential epigenetic mechanism mediating CPC differentiation.
Endocervical-type mucinous borderline tumors are related to endometrioid tumors based on mutation and loss of expression of ARID1A.
GeneRIF
Shih et al., Baltimore, United States. In Int J Gynecol Pathol, 2012
The loss of expression of ARID1A and the presence of inactivating mutations of the ARID1A gene further link this tumor to endometrioid and clear cell tumors, as does the frequent association with endometriosis.
Loss of ARID1A/BAF250a-expression in endometriosis: a biomarker for risk of carcinogenic transformation?
GeneRIF
Imesch et al., Zürich, Switzerland. In Mod Pathol, 2012
The loss of expression of the tumor-suppressor protein ARID1A/BAF250a in some endometriomas possibly indicates a risk of malignant transformation.
Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes.
Impact
GeneRIF
Tan et al., Singapore, Singapore. In Nat Genet, 2012
Recurrent somatic mutations in ARID1A gene is associated with gastric adenocarcinoma.
Frequent loss of tumor suppressor ARID1A protein expression in adenocarcinomas/adenosquamous carcinomas of the uterine cervix.
GeneRIF
Miyazaki et al., Japan. In Int J Gynecol Cancer, 2012
the current study examined the prognostic significance of loss of ARID1A expression in cervical cancer by investigating the relationship between ARID1A immunohistochemical expression and various clinicopathological variables in cervical cancer.
HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase.
Impact
GeneRIF
Hengartner et al., Zürich, Switzerland. In Nature, 2010
human TRP2 counteracts apoptotic cell death induction, possibly by means of its L-dopachrome tautomerase activity, and negatively affects the p53 pathway
Pax3 functions at a nodal point in melanocyte stem cell differentiation.
Impact
Epstein et al., Philadelphia, United States. In Nature, 2005
Pax3 activates expression of Mitf, a transcription factor critical for melanogenesis, while at the same time it competes with Mitf for occupancy of an enhancer required for expression of dopachrome tautomerase, an enzyme that functions in melanin synthesis.
Prediction of disease outcome in melanoma patients by molecular analysis of paraffin-embedded sentinel lymph nodes.
Impact
Taback et al., Santa Monica, United States. In J Clin Oncol, 2003
RESULTS: Marker expression in histopathologically positive and negative SLNs were as follows: 89%, 92%, 35%, and 43% (positive) and 40%, 33%, 5%, and 13% (negative) for tyrosinase, melanoma antigen recognized by T cells-1, tyrosinase-related protein-1, and tyrosinase-related protein-2, respectively.
Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia.
Impact
Chen et al., Bethesda, United States. In Nat Genet, 2003
To confirm the involvement of Grm1 in melanocytic neoplasia, we created an additional transgenic line with Grm1 expression driven by the dopachrome tautomerase promoter.
Pheromones, vomeronasal function, and gender-specific behavior.
Review
Impact
Keverne, Cambridge, United Kingdom. In Cell, 2002
The striking behavioral phenotypes of mice lacking the TRP2 ion channel have highlighted the importance of the vomeronasal organ in gender-specific sexual behavior.
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