Stromal-dependent tumor promotion by MIF family members.
Louisville, United States. In Cell Signal, 2014
One family of soluble factors that is becoming increasingly associated with pro-tumoral phenotypes within tumor microenvironments is that of the migration inhibitory factor family which includes its namesake, MIF, and its only known family member, D-dopachrome tautomerase (D-DT).
CD74 in Kidney Disease.
Madrid, Spain. In Front Immunol, 2014
CD74 (invariant MHC class II) regulates protein trafficking and is a receptor for macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT/MIF-2).
Whitening Effect of Watersoluble Royal Jelly from South Korea.
South Korea. In Korean J Food Sci Anim Resour, 2014
In addition, we investigated the mRNA and protein expression of melanogenesis-related genes such as tyrosinase, tyrosinase related protein-1 (TRP-1) and TRP-2 by reverse transcription-polymerase chain reaction and western blotting.
Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors.
Heidelberg, Germany. In Front Immunol, 2013
A plethora of preclinical models suggests that this immune tolerance pathway - driven by the key and rate-limiting enzymes indoleamine-2,3-dioxygenase and TRP-2,3-dioxygenase - is active in cancer immunity, autoimmunity, infection, transplant rejection, and allergy.
Age-induced hair greying - the multiple effects of oxidative stress.
Princeton, United States. In Int J Cosmet Sci, 2013
With ageing, the bulbar melanocyte expression of anti-oxidant proteins such as BCL-2, and possibly TRP-2, is reduced, and the dedicated enzymatic anti-oxidant defence system throughout the follicle weakens, resulting in enhanced oxidative stress.
Pax3 functions at a nodal point in melanocyte stem cell differentiation.
Philadelphia, United States. In Nature, 2005
Pax3 activates expression of Mitf, a transcription factor critical for melanogenesis, while at the same time it competes with Mitf for occupancy of an enhancer required for expression of dopachrome tautomerase, an enzyme that functions in melanin synthesis.
Prediction of disease outcome in melanoma patients by molecular analysis of paraffin-embedded sentinel lymph nodes.
Santa Monica, United States. In J Clin Oncol, 2003
RESULTS: Marker expression in histopathologically positive and negative SLNs were as follows: 89%, 92%, 35%, and 43% (positive) and 40%, 33%, 5%, and 13% (negative) for tyrosinase, melanoma antigen recognized by T cells-1, tyrosinase-related protein-1, and tyrosinase-related protein-2, respectively.