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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Tumor necrosis factor receptor superfamily, member 19

Troy, Taj, TNFRSF19
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p75, LINGO-1, Nogo, CAN, ACID
Papers on Troy
Corrigendum: A Person-by-Situation Approach to Emotion Regulation: Cognitive Reappraisal Can Either Help or Hurt, Depending on the Context.
New
In Psychol Sci, Feb 2016
UNASSIGNED: Troy, A. S., Shallcross, A. J., & Mauss, I. B. (2013).
A GWAS Meta-analysis and Replication Study Identifies a Novel Locus within CLPTM1L/TERT Associated with Nasopharyngeal Carcinoma in Individuals of Chinese Ancestry.
New
International Nasopharyngeal Carcinoma (NPC) Genetics Working Group et al., Xinhui, China. In Cancer Epidemiol Biomarkers Prev, Jan 2016
Our results also provide support for associations reported from published NPC GWAS-rs6774494 (P = 1.5 × 10(-12); located in the MECOM gene region), rs9510787 (P = 5.0 × 10(-10); located in the TNFRSF19 gene region), and rs1412829/rs4977756/rs1063192 (P = 2.8 × 10(-8), P = 7.0 × 10(-7), and P = 8.4 × 10(-7), respectively; located in the CDKN2A/B gene region).
Genomic Evidence Establishes Anatolia as the Source of the European Neolithic Gene Pool.
New
Götherström et al., Stockholm, Sweden. In Curr Biol, Jan 2016
We present ancient genome-wide sequence data from 6,700-year-old human remains excavated from a Neolithic context in Kumtepe, located in northwestern Anatolia near the well-known (and younger) site Troy [10].
Experimental and Clinical Advances in Immunotherapy Strategies for Spinal Cord Injury Target on MAIs and Their Receptors.
New
Wang et al., Chongqing, China. In Curr Pharm Des, Jan 2016
Interestingly, these three structurally different inhibitors share two common receptors, Nogo-66 receptor (NgR) and paired immunoglobulin-like receptor B (PirB), and transduce the inhibitory signal into neurons via their complex combinant and co-receptors, such as p75 neurotrophin receptor (p75NTR), Nogo receptor-interacting protein 1 (LINGO-1), and TROY.
Propentofylline inhibits glioblastoma cell invasion and survival by targeting the TROY signaling pathway.
New
Tran et al., Phoenix, United States. In J Neurooncol, Dec 2015
We have demonstrated that TROY (TNFRSF19), a member of the TNFR super-family, plays an important role in GBM invasion and resistance.
Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses.
New
Shay et al., Dallas, United States. In Oncogene, Nov 2015
After proton irradiation, a subset of SIR genes (Troy, Sox17, Opg, Faim2, Lpo, Tlr2 and Ptges) and a gene known to be involved in invasiveness (Plat), along with the senescence-associated gene (P19Arf), are markedly increased.
Genetic variants in Nogo receptor signaling pathways may be associated with early life adversity in schizophrenia susceptibility.
New
Fernandez-Enright et al., Wollongong, Australia. In Bba Clin, Jun 2015
The NgR co-receptors include p75 neurotrophin receptor or TNF receptor orphan Y (TROY).
Structural features of the Nogo receptor signaling complexes at the neuron/myelin interface.
Review
Nikolov et al., New York City, United States. In Neurosci Res, 2014
These inhibitors bind and signal through a single receptor/co-receptor complex that comprises of NgR1/LINGO-1 and either p75 or TROY, triggering intracellular downstream signaling that impedes the re-growth of axons.
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium.
Impact
Clevers et al., Dresden, Germany. In Cell, 2013
We find that the stem cell marker Troy is expressed at the gland base by a small subpopulation of fully differentiated chief cells.
Multiple sclerosis: does Nogo play a role?
Review
Petratos et al., Australia. In Neuroscientist, 2013
Nogo-A can only signal through NgR1 upon heteromeric collaboration with p75(NTR), TROY, and LINGO-1 to induce axonal retraction.
Propentofylline targets TROY, a novel microglial signaling pathway.
GeneRIF
De Leo et al., United States. In Plos One, 2011
TROY is expressed in microglia, involved in their migration and targeted by propentofylline.
Tumor necrosis factor-receptor 2 and TROY gene expression patterns in cutaneous squamous cell carcinoma in a Tunisian population.
GeneRIF
Nouira et al., Monastir, Tunisia. In Saudi Med J, 2011
study demonstrated that TNFR2 and TROY mRNA levels are enhanced in cutaneous squamous cell carcinoma cells compared to healthy ones in a Tunisian population
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese.
Impact
Shen et al., Nanjing, China. In Nat Genet, 2011
The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1.0 × 10(-27), respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12,
A strong synergistic epistasis between FAM134B and TNFRSF19 on the susceptibility to vascular dementia.
GeneRIF
Lee et al., Seoul, South Korea. In Psychiatr Genet, 2011
The FAM134B and TNFRSF19 showed a dramatically strong synergistic epistasis in explaining the genetic dissection of the susceptibility to complex vascular dementia.
Emerging functions of myelin-associated proteins during development, neuronal plasticity, and neurodegeneration.
Review
del Río et al., Barcelona, Spain. In Faseb J, 2011
Three of these proteins, Nogo-A, MAG, and OMgp, share two common neuronal receptors: NgR1, together with its coreceptors [p75(NTR), TROY, and Lingo-1]; and the recently described paired immunoglobulin-like receptor B (PirB).
Targeting the Nogo receptor complex in diseases of the central nervous system.
Review
Reindl et al., Innsbruck, Austria. In Curr Med Chem, 2010
The third member of the NgR complex is either the p75 neurotrophin receptor, TROY, or an as yet unidentified co-receptor.
TROY (TNFRSF19) is overexpressed in advanced glial tumors and promotes glioblastoma cell invasion via Pyk2-Rac1 signaling.
GeneRIF
Tran et al., Phoenix, United States. In Mol Cancer Res, 2010
TNFRSF19 overexpression in glioma cells activates Rac1 signaling in a Pyk2-dependent manner to drive glioma cell invasion and migration
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
Impact
GeneRIF
Zeng et al., Guangzhou, China. In Nat Genet, 2010
Findings provide new insights into the pathogenesis of NPC by highlighting the involvement of pathways related to TNFRSF19 and MDS1-EVI1 in addition to HLA molecules.
Troy/Taj and its role in CNS axon regeneration.
Review
Mi, Cambridge, United States. In Cytokine Growth Factor Rev, 2008
Troy/Taj is an orphan TNF family receptor that is broadly expressed in postnatal and adult neurons.
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