Diversity in mechanism and function of tRNA methyltransferases.
Columbus, United States. In Rna Biol, 2014
Here we review recent advances in tRNA methyltransferase mechanism and function with a particular emphasis on discoveries of alternative substrate specificities and chemistry associated with some methyltransferases.
tRNA modifications regulate translation during cellular stress.
Cambridge, United States. In Febs Lett, 2014
In support of this general model of translational control of stress response, studies making use of detailed measures of translation, tRNA methyltransferase mutants, and computational and mass spectrometry approaches reveal that stress reprograms tRNA modifications to translationally regulate MoTTs linked to arginine and leucine codons, which helps cells survive insults by damaging agents.