The effect of small molecules on nuclear-encoded translation diseases.
Jerusalem, Israel. In Biochimie, 2014
We evaluated the effect of seven small molecules with reported therapeutic potential in fibroblasts of four patients with combined respiratory complex disorders, each harboring a known mutation in a different nuclear-encoded component of the mitochondrial translation machinery: EFTs, GFM1, MRPS22 and TRMU.
Dynamics of cell shape inheritance in fission yeast.
Cambridge, United Kingdom. In Plos One, 2013
Finally, we find that one of those pathways corresponds to the swc2-swr1-vps71 SWR1/SRCAP chromatin remodelling complex, which acts additively to the known mal3-tip1-mto1-mto2 microtubule and tea1-tea2-tea4-pom1 polarity machineries.