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TRM8 Trm8p

Trm8, METTL1, YDL201w, Trm8p, DNA methyltransferase-like
This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: ACID, caspase-3, OUT, Saki, CAN
Papers on Trm8
A new type of protein lysine methyltransferase trimethylates Lys-79 of elongation factor 1A.
Clarke et al., Los Angeles, United States. In Biochem Biophys Res Commun, 2015
Here we report the identification of a new type of protein lysine methyltransferase, Efm5 (Ygr001c), which was initially classified as N6-adenine DNA methyltransferase-like.
tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells.
Tatsuka et al., Hiroshima, Japan. In Plos Genet, 2014
The tRNA modifying enzymes, NSUN2 and METTL1, are mammalian orthologs of yeast Trm4 and Trm8, which are required for protecting tRNA against RTD.
Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis.
Matesanz et al., Granada, Spain. In J Med Genet, 2013
BACKGROUND AND AIM: Several studies have highlighted the association of the 12q13.3-12q14.1 region with coeliac disease, type 1 diabetes, rheumatoid arthritis and multiple sclerosis (MS); however, the causal variants underlying diseases are still unclear.
The yeast rapid tRNA decay pathway competes with elongation factor 1A for substrate tRNAs and acts on tRNAs lacking one or more of several modifications.
Phizicky et al., Rochester, United States. In Rna, 2012
Thus, trm8-Δ trm4-Δ strains are temperature sensitive due to lack of m(7)G(46) and m(5)C and the consequent RTD of tRNA(Val(AAC)), and tan1-Δ trm44-Δ strains are temperature sensitive due to lack of ac(4)C(12) and Um(44) and the consequent RTD of tRNA(Ser(CGA)) and tRNA(Ser(UGA)).
An O6-methylguanine-DNA methyltransferase-like protein from Thermus thermophilus interacts with a nucleotide excision repair protein.
Masui et al., Toyonaka, Japan. In J Biochem, 2008
The major damage to DNA caused by alkylating agents involves the formation of O6-methylguanine (O6-meG).
Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism.
Jeltsch et al., Bremen, Germany. In Rna, 2008
Using site directed mutagenesis, we show here that the enzyme has a DNA methyltransferase-like mechanism, because similar residues from motifs IV, VI, and VIII are involved in catalysis as identified in DNA methyltransferases.
Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1.
Phizicky et al., Rochester, United States. In Genes Dev, 2008
Recent evidence suggests that hypomodified mature tRNA in yeast can undergo a quality control check by a rapid tRNA decay (RTD) pathway, since mature tRNA(Val(AAC)) lacking 7-methylguanosine and 5-methylcytidine is rapidly degraded and deacylated at 37 degrees C in a trm8-Delta trm4-Delta strain, resulting in temperature-sensitive growth.
Rapid tRNA decay can result from lack of nonessential modifications.
Phizicky et al., Rochester, United States. In Mol Cell, 2006
We show here that m7G46 methyltransferase Trm8p/Trm82p acts as a hub of synthetic interactions with several tRNA modification enzymes, resulting in temperature-sensitive growth.
Meiotic and epigenetic aberrations in Dnmt3L-deficient male germ cells.
Sasaki et al., Mishima, Japan. In Mol Reprod Dev, 2006
The DNA methyltransferase-like protein Dnmt3L is necessary for the establishment of genomic imprints in oogenesis and for normal spermatogenesis (Bourc'his et al., 2001; Hata et al., 2002).
Sequence-structure-function relationships of a tRNA (m7G46) methyltransferase studied by homology modeling and site-directed mutagenesis.
Bujnicki et al., Warsaw, Poland. In Proteins, 2005
The Escherichia coli TrmB protein and its Saccharomyces cerevisiae ortholog Trm8p catalyze the S-adenosyl-L-methionine-dependent formation of 7-methylguanosine at position 46 (m7G46) in tRNA.
The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.
Cohen et al., Dundee, United Kingdom. In Embo J, 2005
A substrate for protein kinase B (PKB)alpha in HeLa cell extracts was identified as methyltransferase-like protein-1 (METTL1), the orthologue of trm8, which catalyses the 7-methylguanosine modification of tRNA in Saccharomyces cerevisiae.
tRNA m7G methyltransferase Trm8p/Trm82p: evidence linking activity to a growth phenotype and implicating Trm82p in maintaining levels of active Trm8p.
Phizicky et al., Rochester, United States. In Rna, 2005
a second role of Trm82p is to stabilize Trm8p in an active conformation
CDK4 is a probable target gene in a novel amplicon at 12q13.3-q14.1 in lung cancer.
Anttila et al., Helsinki, Finland. In Genes Chromosomes Cancer, 2005
Semiquantitative RT-PCR analyses of 13 genes in this region showed that four of them (CDK4, CYP27B1, METTL1, and TSFM) were also highly up-regulated.
The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a.
Hsieh et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2003
Dnmt3L is required for the establishment of maternal methylation imprints at imprinting centers (ICs).
Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.
Phizicky et al., Rochester, United States. In Rna, 2002
ORF YDL201w encodes Trm8, a protein that is highly conserved in prokaryotes and eukaryotes and that contains an S-adenosylmethionine binding domain.
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