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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Oct 2014.

Neurotrophic tyrosine kinase, receptor, type 3

trkC, NTRK3
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: trkA, TrkB, neurotrophin-3, Brain-derived neurotrophic factor, NGF
Papers on trkC
Dynamic Nature of the p75 Neurotrophin Receptor in Response to Injury and Disease.
New
Williams et al., Chapel Hill, United States. In J Neuroimmune Pharmacol, 31 Dec 2014
Neurotrophins and their respective tropomyosin related kinase (Trk) receptors (TrkA, TrkB, and TrkC) and the p75 neurotrophin receptor (p75(NTR)) play a fundamental role in the development and maintenance of the nervous system making them important targets for treatment of neurodegenerative diseases.
Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity.
New
the IMAGE Consortium et al., Greensboro, United States. In Am J Med Genet B Neuropsychiatr Genet, 25 Nov 2014
SNPs within neurotrophic (NTRK3) and cytokine genes (CNTFR) were associated with ADHD inattentive symptom severity.
Dehydroepiandrosterone: an ancestral ligand of neurotrophin receptors.
New
Gravanis et al., Greece. In Endocrinology, 20 Nov 2014
Intrigued by its pleiotropic effects in the nervous system of a variety of species, we have investigated the ability of DHEA to interact with the other two mammalian neurotrophin receptors i.e. the TrkB and TrkC, as well as their invertebrate counterparts (orthologs) in mollusks Lymnaea (Ltrk) and Aplysia (ApTrk), and in cephalochordate fish Amphioxus (AmphiTrk).
5-(4-((4-[(18)F]fluorobenzyl)oxy)-3-methoxybenzyl)pyrimidine-2,4-diamine: A selective dual inhibitor for potential PET imaging of Trk/CSF-1R.
New
Schirrmacher et al., Montréal, Canada. In Bioorg Med Chem Lett, 15 Nov 2014
The 2,4-diaminopyrimidine inhibitor GW2580 (9) has been previously reported as a highly selective low nanomolar TrkB/TrkC/CSF-1R inhibitor.
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
New
Impact
Mullighan et al., Memphis, United States. In N Engl J Med, 11 Oct 2014
Cell lines and human leukemic cells expressing ABL1, ABL2, CSF1R, and PDGFRB fusions were sensitive in vitro to dasatinib, EPOR and JAK2 rearrangements were sensitive to ruxolitinib, and the ETV6-NTRK3 fusion was sensitive to crizotinib.
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma.
New
Impact
St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project et al., Memphis, United States. In Nat Genet, May 2014
Structural variants generating fusion genes were found in 47% of DIPGs and NBS-HGGs, with recurrent fusions involving the neurotrophin receptor genes NTRK1, NTRK2 and NTRK3 in 40% of NBS-HGGs in infants.
Distant metastatic spread of molecularly proven infantile fibrosarcoma of the chest in a 2-month-old girl: case report and review of literature.
Review
New
Anderson et al., Rotterdam, Netherlands. In J Pediatr Hematol Oncol, Apr 2014
Infantile fibrosarcoma (IFS) is a malignant neoplasm, arising in children younger than 2 years of age and with a hallmark chromosomal translocation t(12;15)(p13;q26) encoding an ETV6-NTRK3 fusion oncoprotein.
The cytopathologic features of mammary analog secretory carcinoma and its mimics.
New
Baloch et al., Philadelphia, United States. In Cytojournal, Dec 2013
This tumor harbors a unique translocation, t(12;15)(p13;q25) that results in the fusion of ETV6 with NTRK3 which produces a transformative chimeric tyrosine kinase.
Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player.
Review
New
Turnley et al., Melbourne, Australia. In Front Mol Neurosci, Dec 2013
They do this by binding to their cognate receptors, members of the Tropomyosin-related kinase (Trk) receptor tyrosine kinase family, namely TrkA, TrkB, and TrkC.
NGF, BDNF, NT3, and NT4.
Review
New
Bothwell, Seattle, United States. In Handb Exp Pharmacol, Dec 2013
Four neurotrophins, NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3), and neurotrophin-4 (NT4), regulate a wide variety of neural functions, acting upon p75NTR, TrkA, TrkB, and TrkC receptors.
The role of rab proteins in neuronal cells and in the trafficking of neurotrophin receptors.
Review
New
Cogli et al., Lecce, Italy. In Membranes (basel), Dec 2013
Neurotrophins exert their role by binding to their receptors, the Trk family of receptor tyrosine kinases (TrkA, TrkB, and TrkC) and p75NTR, a member of the tumor necrosis factor (TNF) receptor superfamily.
Functional switch from pro-neurotrophins to mature neurotrophins.
Review
New
Chen et al., Xi'an, China. In Curr Protein Pept Sci, Nov 2013
While mature neurotrophins exhibit neuroprotective roles via tyrosine kinase receptors (TrkA, TrkB and TrkC), the proforms of neurotrophins show totally-different biological effects that may induce apoptotic cell death of neurons by triggering p75NTR-sortilin signaling cascades.
Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.
Review
New
Impact
Massa et al., Stanford, United States. In Nat Rev Drug Discov, Jul 2013
One strategy to overcome these limitations is to target individual neurotrophin receptors — such as tropomyosin receptor kinase A (TRKA), TRKB, TRKC, the p75 neurotrophin receptor or sortilin — with small-molecule ligands.
Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells.
New
Impact
Lindquist et al., Cambridge, United States. In Nat Biotechnol, Jul 2013
Demonstrating the value of the assay, we identify ETV6-NTRK3 as a target of the FDA-approved drug crizotinib (Xalkori).
Expression of neurotrophin receptors by retinoinvasive uveal melanoma.
GeneRIF
Finger et al., New York City, United States. In Melanoma Res, 2012
expression of neurotrophin receptors Pan-Trk, p75 neurotrophin receptor (p75(NTR) and ciliary neurotrophic factor receptor-alpha in ulveal melanoma does not show a role in growth.
A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation.
GeneRIF
Sorensen et al., Vancouver, Canada. In Oncogene, 2012
find that both IRS1 and kinase active IGF1R are required for ETV6-NTRK3 transformation, that tyrosine phosphorylated IRS1 is present in high molecular weight complexes with EN and IGF1R, and that EN colocalizes with IGF1R at the plasma membrane
Transcriptional regulation of TRKC by SOX2 in human embryonic stem cells.
GeneRIF
Donovan et al., Irvine, United States. In Stem Cell Res, 2012
SOX2 utilizes a specific binding motif to directly interact with the TRKC regulatory region.
Cograft of neural stem cells and schwann cells overexpressing TrkC and neurotrophin-3 respectively after rat spinal cord transection.
GeneRIF
Teng et al., Guangzhou, China. In Biomaterials, 2011
Transplantation of overexpressing neurotrophin-3-Schwann cells + trkC-neural stem cells in Gelfoam into the lesion gap immediately following injury results in significantly improved relay of the cortical motor evoked potential.
Neurotrophin receptor TrkC is an entry receptor for Trypanosoma cruzi in neural, glial, and epithelial cells.
GeneRIF
Pereiraperrin et al., Boston, United States. In Infect Immun, 2011
TrkC is implicated as a functional PDNF receptor in cell entry, independently of sialic acid recognition, mediating broad T. cruzi infection both in vitro and in vivo.
Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not.
Impact
GeneRIF
Barde et al., Basel, Switzerland. In Nature, 2010
TrkA and TrkC instruct developing neurons to die, both in vitro and in vivo. By contrast, TrkB, a closely related receptor primarily expressed in the central nervous system, does not.
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