Dehydroepiandrosterone: an ancestral ligand of neurotrophin receptors.
Greece. In Endocrinology, 20 Nov 2014
Intrigued by its pleiotropic effects in the nervous system of a variety of species, we have investigated the ability of DHEA to interact with the other two mammalian neurotrophin receptors i.e. the TrkB and TrkC, as well as their invertebrate counterparts (orthologs) in mollusks Lymnaea (Ltrk) and Aplysia (ApTrk), and in cephalochordate fish Amphioxus (AmphiTrk).
NGF, BDNF, NT3, and NT4.
Seattle, United States. In Handb Exp Pharmacol, Dec 2013
Four neurotrophins, NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3), and neurotrophin-4 (NT4), regulate a wide variety of neural functions, acting upon p75NTR, TrkA, TrkB, and TrkC receptors.
Functional switch from pro-neurotrophins to mature neurotrophins.
Xi'an, China. In Curr Protein Pept Sci, Nov 2013
While mature neurotrophins exhibit neuroprotective roles via tyrosine kinase receptors (TrkA, TrkB and TrkC), the proforms of neurotrophins show totally-different biological effects that may induce apoptotic cell death of neurons by triggering p75NTR-sortilin signaling cascades.