gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 09 Nov 2015.

Neurotrophic tyrosine kinase, receptor, type 3

trkC, NTRK3
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: trkA, TrkB, neurotrophin-3, Brain-derived neurotrophic factor, NGF
Papers on trkC
The Trk family of neurotrophin receptors is downregulated in the lumbar spines of rats with congenital kyphoscoliosis.
Koibuchi et al., Maebashi, Japan. In Mol Cell Biochem, 07 Dec 2015
Interestingly, the flexion sites of the IS rats showed low expression levels of tropomyosin receptor kinases (Trks: TrkA, TrkB, and TrkC), which belong to the neurotrophic receptor tyrosine kinase family.
Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling.
Bothwell et al., Tokyo, Japan. In Mol Cell Neurosci, 03 Dec 2015
UNASSIGNED: Neurotrophins, essential regulators of many aspects of neuronal differentiation and function, signal via four receptors, p75, TrkA, TrkB and TrkC.
Effects of hindlimb unloading on neurotrophins in the rat spinal cord and soleus muscle.
Zhang et al., Taiyuan, China. In Brain Res, 01 Dec 2015
UNASSIGNED: The aim of the present study was to investigate the effects of hindlimb unloading (HU) on the expression of neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF), together with the expression of their high-affinity receptors tropomyosin receptor kinase C (TrkC) and tropomyosin receptor kinase B (TrkB), in lumbar (L4-6) segment of the spinal cord and in the soleus muscle.
A pediatric case of mammary analogue secretory carcinoma within the parotid.
Chan et al., Aurora, United States. In Am J Otolaryngol, 30 Nov 2015
It is notable for a characteristic t(12;15)(p13;q25) translocation that results in a unique fusion protein, ETV6-NTRK3.
The p75 neurotrophin receptor: at the crossroad of neural repair and death.
Williams et al., Chapel Hill, United States. In Neural Regen Res, May 2015
The strong repair and pro-survival functions of neurotrophins at their primary receptors, TrkA, TrkB and TrkC, have made them attractive candidates for treatment of nervous system injury and disease.
Fetal presentation of congenital fibrosarcoma of the meninges: case report and literature review.
Laquerrière et al., In Clin Neuropathol, Mar 2015
A reverse transcription polymerase chain reaction assay was performed to detect the gene fusion ETV6-NTRK3 transcript.
TRKing down an old oncogene in a new era of targeted therapy.
Doebele et al., Aurora, United States. In Cancer Discov, Jan 2015
Oncogenic alterations, most commonly gene fusions, have now been detected for the genes encoding the TRKA, TRKB, and TRKC receptor tyrosine kinases across multiple tumor types.
Concurrent Mutations in ATM and Genes Associated with Common γ Chain Signaling in Peripheral T Cell Lymphoma.
Banerjee et al., Baltimore, United States. In Plos One, Dec 2014
Our analysis identified recurrent somatic missense or nonsense mutations in 70 genes, 9 of which contained mutations predicted significant by all 4 algorithms: ATM, RUNX1T1, WDR17, NTRK3, TP53, TRMT12, CACNA2D1, INTS8, and KCNH8.
Neurodevelopment. Dendrite morphogenesis depends on relative levels of NT-3/TrkC signaling.
Luo et al., Stanford, United States. In Science, Dec 2014
We show that the neurotrophin receptor tropomyosin-related kinase C (TrkC) is required for dendritic growth and branching of mouse cerebellar Purkinje cells.
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
Mullighan et al., Memphis, United States. In N Engl J Med, Oct 2014
Cell lines and human leukemic cells expressing ABL1, ABL2, CSF1R, and PDGFRB fusions were sensitive in vitro to dasatinib, EPOR and JAK2 rearrangements were sensitive to ruxolitinib, and the ETV6-NTRK3 fusion was sensitive to crizotinib.
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma.
St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project et al., Memphis, United States. In Nat Genet, May 2014
Structural variants generating fusion genes were found in 47% of DIPGs and NBS-HGGs, with recurrent fusions involving the neurotrophin receptor genes NTRK1, NTRK2 and NTRK3 in 40% of NBS-HGGs in infants.
Mammary analog secretory carcinoma of salivary gland with high-grade histology arising in hard palate, report of a case and review of literature.
Fung et al., United States. In Int J Clin Exp Pathol, 2013
This tumor shares histologic features, immunohistochemical profile, and a highly specific genetic translocation, ETV6-NTRK3, with secretory carcinoma of breast.
The role of rab proteins in neuronal cells and in the trafficking of neurotrophin receptors.
Cogli et al., Lecce, Italy. In Membranes (basel), 2013
Neurotrophins exert their role by binding to their receptors, the Trk family of receptor tyrosine kinases (TrkA, TrkB, and TrkC) and p75NTR, a member of the tumor necrosis factor (TNF) receptor superfamily.
Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells.
Lindquist et al., Cambridge, United States. In Nat Biotechnol, 2013
Demonstrating the value of the assay, we identify ETV6-NTRK3 as a target of the FDA-approved drug crizotinib (Xalkori).
Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.
Massa et al., Stanford, United States. In Nat Rev Drug Discov, 2013
One strategy to overcome these limitations is to target individual neurotrophin receptors — such as tropomyosin receptor kinase A (TRKA), TRKB, TRKC, the p75 neurotrophin receptor or sortilin — with small-molecule ligands.
Expression of neurotrophin receptors by retinoinvasive uveal melanoma.
Finger et al., New York City, United States. In Melanoma Res, 2012
expression of neurotrophin receptors Pan-Trk, p75 neurotrophin receptor (p75(NTR) and ciliary neurotrophic factor receptor-alpha in ulveal melanoma does not show a role in growth.
A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation.
Sorensen et al., Vancouver, Canada. In Oncogene, 2012
find that both IRS1 and kinase active IGF1R are required for ETV6-NTRK3 transformation, that tyrosine phosphorylated IRS1 is present in high molecular weight complexes with EN and IGF1R, and that EN colocalizes with IGF1R at the plasma membrane
Transcriptional regulation of TRKC by SOX2 in human embryonic stem cells.
Donovan et al., Irvine, United States. In Stem Cell Res, 2012
SOX2 utilizes a specific binding motif to directly interact with the TRKC regulatory region.
Cograft of neural stem cells and schwann cells overexpressing TrkC and neurotrophin-3 respectively after rat spinal cord transection.
Teng et al., Guangzhou, China. In Biomaterials, 2011
Transplantation of overexpressing neurotrophin-3-Schwann cells + trkC-neural stem cells in Gelfoam into the lesion gap immediately following injury results in significantly improved relay of the cortical motor evoked potential.
Neurotrophin receptor TrkC is an entry receptor for Trypanosoma cruzi in neural, glial, and epithelial cells.
Pereiraperrin et al., Boston, United States. In Infect Immun, 2011
TrkC is implicated as a functional PDNF receptor in cell entry, independently of sialic acid recognition, mediating broad T. cruzi infection both in vitro and in vivo.
share on facebooktweetadd +1mail to friends