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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Neurotrophic tyrosine kinase, receptor, type 3

trkC, NTRK3
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: trkA, TrkB, neurotrophin-3, Brain-derived neurotrophic factor, NGF
Papers on trkC
An epigenetic biomarker panel for glioblastoma multiforme personalized medicine through DNA methylation analysis of human embryonic stem cell-like signature.
New
Tian et al., Tainan City, Taiwan. In Omics, May 2014
We further identified a refined signature of 36 genes as the gene panel, including SOX2, POU3F2, FGFR2, GAP43, NTRK2, NTRK3, and NKX2-2, which are highly enriched in the nervous system.
Developmental changes in the protective effect of exogenous brain-derived neurotrophic factor and neurotrophin-3 against ototoxic drugs in cultured rat vestibular ganglion neurons.
New
Yamasoba et al., Tokyo, Japan. In Cell Tissue Res, May 2014
Analysis of the changes in the expression of the receptors of NTFs revealed that expression of TrkB and TrkC proteins and their mRNA did not change during the developmental period, whereas expression of p75(NTR) protein was down-regulated together with that of p75(NTR) mRNA during the developmental period.
Cytopathological features of mammary analogue secretory carcinoma-Review of literature.
New
Ohbayashi et al., Kashihara, Japan. In Diagn Cytopathol, Apr 2014
UNLABELLED: Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor that morphologically resembles mammary secretory carcinoma and carries the identical ETV6-NTRK3 fusion gene.
Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors.
New
Saragovi et al., Montréal, Canada. In Plos One, Dec 2013
These are the natural ligands for TrkC, TrkA, and TrkB receptors, respectively.
NGF, BDNF, NT3, and NT4.
New
Bothwell, Seattle, United States. In Handb Exp Pharmacol, Dec 2013
Four neurotrophins, NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3), and neurotrophin-4 (NT4), regulate a wide variety of neural functions, acting upon p75NTR, TrkA, TrkB, and TrkC receptors.
Dual innervation of neonatal Merkel cells in mouse touch domes.
New
Luo et al., Philadelphia, United States. In Plos One, Dec 2013
It was previously shown that neurotrophic factor NT3 and its receptor TrkC play crucial roles in controlling touch dome Merkel cell innervation of NFH+ fibers.
A case with sacrococcygeal primitive myxoid mesenchymal tumor of infancy: a case report and review of the literature.
Review
New
Yamaguchi et al., Tokyo, Japan. In J Pediatr Hematol Oncol, Oct 2013
Neither the ETV6-NTRK3 fusion gene nor the FUS gene rearrangement was detected.
Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells.
New
Impact
Lindquist et al., Cambridge, United States. In Nat Biotechnol, Jul 2013
Demonstrating the value of the assay, we identify ETV6-NTRK3 as a target of the FDA-approved drug crizotinib (Xalkori).
Fusion oncogenes in salivary gland tumors: molecular and clinical consequences.
Review
New
Stenman, Göteborg, Sweden. In Head Neck Pathol, Jul 2013
Examples of clinically significant gene fusions in salivary gland cancers are the MYB-NFIB fusion specific for adenoid cystic carcinoma, the CRTC1-MAML2 fusion typical of low/intermediate-grade mucoepidermoid carcinoma, and the recently identified ETV6-NTRK3 fusion in mammary analogue secretory carcinoma.
Mammary analogue secretory carcinoma of salivary gland origin: an update and expanded morphologic and immunohistochemical spectrum of recently described entity.
Review
New
Skalova, Plzeň, Czech Republic. In Head Neck Pathol, Jul 2013
Akin to secretory breast cancer, MASC expresses S-100 protein, mammaglobin, vimentin, and harbors a t(12;15) (p13;q25) translocation which leads to ETV6-NTRK3 fusion product.
Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.
Review
New
Impact
Massa et al., Stanford, United States. In Nat Rev Drug Discov, Jul 2013
One strategy to overcome these limitations is to target individual neurotrophin receptors — such as tropomyosin receptor kinase A (TRKA), TRKB, TRKC, the p75 neurotrophin receptor or sortilin — with small-molecule ligands.
Impact of genetic targets on primary brain tumor therapy: what's ready for prime time?
Review
Glantz et al., State College, United States. In Adv Exp Med Biol, 2012
In medulloblastomas, markers of WNT activation, MYCC/MCYN amplification, and TrkC expression levels are reliable prognostic indicators, but do not yet drive specific treatment selection.
Expression of neurotrophin receptors by retinoinvasive uveal melanoma.
GeneRIF
Finger et al., New York City, United States. In Melanoma Res, 2012
expression of neurotrophin receptors Pan-Trk, p75 neurotrophin receptor (p75(NTR) and ciliary neurotrophic factor receptor-alpha in ulveal melanoma does not show a role in growth.
A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation.
GeneRIF
Sorensen et al., Vancouver, Canada. In Oncogene, 2012
find that both IRS1 and kinase active IGF1R are required for ETV6-NTRK3 transformation, that tyrosine phosphorylated IRS1 is present in high molecular weight complexes with EN and IGF1R, and that EN colocalizes with IGF1R at the plasma membrane
Transcriptional regulation of TRKC by SOX2 in human embryonic stem cells.
GeneRIF
Donovan et al., Irvine, United States. In Stem Cell Res, 2012
SOX2 utilizes a specific binding motif to directly interact with the TRKC regulatory region.
Cograft of neural stem cells and schwann cells overexpressing TrkC and neurotrophin-3 respectively after rat spinal cord transection.
GeneRIF
Teng et al., Guangzhou, China. In Biomaterials, 2011
Transplantation of overexpressing neurotrophin-3-Schwann cells + trkC-neural stem cells in Gelfoam into the lesion gap immediately following injury results in significantly improved relay of the cortical motor evoked potential.
Neurotrophin receptor TrkC is an entry receptor for Trypanosoma cruzi in neural, glial, and epithelial cells.
GeneRIF
Pereiraperrin et al., Boston, United States. In Infect Immun, 2011
TrkC is implicated as a functional PDNF receptor in cell entry, independently of sialic acid recognition, mediating broad T. cruzi infection both in vitro and in vivo.
Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not.
Impact
GeneRIF
Barde et al., Basel, Switzerland. In Nature, 2010
TrkA and TrkC instruct developing neurons to die, both in vitro and in vivo. By contrast, TrkB, a closely related receptor primarily expressed in the central nervous system, does not.
ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex.
Impact
GeneRIF
Orkin et al., Boston, United States. In Cancer Cell, 2007
Using a conditional knock-in mouse model, the authors showed that ETV6(mouse)-NTRK3(human) fusion protein targeted committed alveolar bipotent or CD61(+) luminal progenitors for tumorigenesis via AP1 activation.
Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma.
Impact
Gilbertson et al., Memphis, United States. In J Clin Oncol, 2004
Tumor ERBB2 protein and MYCC, MYCN, and TRKC mRNA levels were measured blind to clinical details using Western blotting and real-time polymerase chain reaction, respectively.
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