GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Neurotrophic tyrosine kinase, receptor, type 3
trkC, NTRK3
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] (from
NCBI)
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Papers on
trkC
EGF transactivation of Trk receptors regulates the migration of newborn cortical neurons.
New
Würzburg, Germany. In Nat Neurosci, 17 Mar 2013
We found that TrkB and TrkC, the receptors for brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are activated by epidermal growth factor receptor (EGFR) signaling rather than by BDNF or NT-3 in embryonic mouse cortical precursor cells.
Trypanosoma cruzi highjacks TrkC to enter cardiomyocytes and cardiac fibroblasts while exploiting TrkA for cardioprotection against oxidative stress.
New
Boston, United States. In Cell Microbiol, 16 Mar 2013
Here we show that antibodies against neurotrophin (NT) receptor TrkC, but not against family members TrkA and TrkB, prevent T cruzi from invading primary cultures of cardiomyocytes and cardiac fibroblasts.
Small Molecule Ligands For Active Targeting Of TrkC-expressing Tumor Cells.
New
Turkmenistan. In Acs Med Chem Lett, Jan 2013
A small molecule motif was used in "active targeting" to deliver cytotoxic substances into tumor cells that express the TrkC receptor.
Trypanosoma cruzi Coaxes Cardiac Fibroblasts into Preventing Cardiomyocyte Death by Activating Nerve Growth Factor Receptor TrkA.
New
Boston, United States. In Plos One, Dec 2012
RESULTS: Basal levels of TrkA and TrkC in primary CFs are comparable to those in cardiomyocytes.
Differentiation of human embryonic stem cells into cells with corneal keratocyte phenotype.
New
Pittsburgh, United States. In Plos One, Dec 2012
Gene expression, examined by quantitative RT-PCR, found hES cells co-cultured with PA6 cells for 6 days to upregulate expression of neural crest genes including NGFR, SNAI1, NTRK3, SOX9, and MSX1.
Neurotrophins and cell death.
Review
New
Lyon, France. In Exp Cell Res, Aug 2012
They do so by interacting with their main tyrosine kinase receptors TrkA, TrkB, TrkC and p75(NTR).
Pleiotropic effects of the bone morphogenetic proteins on development of the enteric nervous system.
Review
New
New York City, United States. In Dev Neurobiol, Jun 2012
Furthermore, BMPs promote growth factor dependency for survival of ENS neurons (on NT-3) and glia (on GGF-2) by inducing TrkC (neurons) and ErbB3 (glia).
Immunohistochemical profile of neurotrophins and MIB-1 in jugulotympanic paragangliomas: prognostic value and review of the literature.
Review
Roma, Italy. In Int J Immunopathol Pharmacol, 2012
We observed a general positivity for NGF - TrKA - NT4 - TrKC in the cytoplasm, and a strong expression for BDNF in the extracellular space.
The neurotrophin family of neurotrophic factors: an overview.
Review
Padova, Italy. In Methods Mol Biol, 2011
Biological effects of each of the four mammalian neurotrophins are mediated through activation of one or more of the three members of the tropomyosin-related kinase (Trk) family of receptor tyrosine kinases (TrkA, TrkB, and TrkC).
Secretory breast carcinoma: unique, triple-negative carcinoma with a favorable prognosis and characteristic molecular expression.
Review
Hamilton, Canada. In Arch Pathol Lab Med, 2011
Recent studies have shown the characteristic molecular feature: a balanced translocation t(12;15), resulting in an ETS variant 6-neurotrophic tyrosine kinase receptor type 3 (ETV6-NTRK3) fusion gene encoding a chimeric tyrosine kinase.
Dysregulated TRK signalling is a therapeutic target in CYLD defective tumours.
GeneRIF
Newcastle upon Tyne, United Kingdom. In Oncogene, 2011
Data indicate that the CYLD mutant tumours showed dysregulated tropomyosin kinase (TRK) signalling, with overexpression of TRKB and TRKC in tumours.
The TrkB-positive dopaminergic neurons are less sensitive to MPTP insult in the substantia nigra of adult C57/BL mice.
GeneRIF
Xi'an, China. In Neurochem Res, 2011
Data describe the distribution and changes of TrkB and TrkC in the dopamine neurons of the substantia nigra by comparison of control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Parkinson disease mouse model.
Cograft of neural stem cells and schwann cells overexpressing TrkC and neurotrophin-3 respectively after rat spinal cord transection.
GeneRIF
Guangzhou, China. In Biomaterials, 2011
Transplantation of overexpressing neurotrophin-3-Schwann cells + trkC-neural stem cells in Gelfoam into the lesion gap immediately following injury results in significantly improved relay of the cortical motor evoked potential.
Neurotrophin receptor TrkC is an entry receptor for Trypanosoma cruzi in neural, glial, and epithelial cells.
GeneRIF
Boston, United States. In Infect Immun, 2011
TrkC is implicated as a functional PDNF receptor in cell entry, independently of sialic acid recognition, mediating broad T. cruzi infection both in vitro and in vivo.
Response of medulloblastoma cells to vincristine and lomustine: role of TRKC, CTNNB1 and STK15.
GeneRIF
Riyadh, Saudi Arabia. In Anticancer Res, 2011
Low TRKC is associated with low vincristine and lomustine response in medulloblastoma.
Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not.
Impact
GeneRIF
Basel, Switzerland. In Nature, 2010
TrkA and TrkC instruct developing neurons to die, both in vitro and in vivo. By contrast, TrkB, a closely related receptor primarily expressed in the central nervous system, does not.
ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex.
Impact
GeneRIF
Boston, United States. In Cancer Cell, 2007
Using a conditional knock-in mouse model, the authors showed that ETV6(mouse)-NTRK3(human) fusion protein targeted committed alveolar bipotent or CD61(+) luminal progenitors for tumorigenesis via AP1 activation.
Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma.
Impact
Memphis, United States. In J Clin Oncol, 2004
Tumor ERBB2 protein and MYCC, MYCN, and TRKC mRNA levels were measured blind to clinical details using Western blotting and real-time polymerase chain reaction, respectively.
ETV6-NTRK3--Trk-ing the primary event in human secretory breast cancer.
Review
Impact
Dallas, United States. In Cancer Cell, 2002
In this issue of Cancer Cell, propose a single chromosomal translocation as the cause of a particularly troubling form of breast cancer, secretory carcinoma.
Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma.
Impact
GeneRIF
Vancouver, Canada. In Cancer Cell, 2002
Expression of the ETV6-NTRK3 gene fusion is a primary event in human secretory breast carcinoma.
