Functional switch from pro-neurotrophins to mature neurotrophins.
Xi'an, China. In Curr Protein Pept Sci, 30 Nov 2013
While mature neurotrophins exhibit neuroprotective roles via tyrosine kinase receptors (TrkA, TrkB and TrkC), the proforms of neurotrophins show totally-different biological effects that may induce apoptotic cell death of neurons by triggering p75NTR-sortilin signaling cascades.
Morphologic features of carcinomas with recurrent gene fusions.
Jinan, China. In Adv Anat Pathol, Nov 2012
In this review, we will summarize the histologic features of known recurrent genomic rearrangements in carcinomas, especially focusing on TMPRSS2-ERG fusion in prostate cancer, EML4-ALK in lung cancer, ETV6-NTRK3 in secretory breast cancer, RET/PTC and PAX8/PPARγ1 rearrangements in thyroid cancer.
The Trk A, B, C's of neurotrophins in the cochlea.
Iowa City, United States. In Anat Rec (hoboken), Nov 2012
Remarkably, NT-3 and BDNF have different, even opposing, effects on SGN physiology despite the close similarity of their receptors TrkB and TrkC.