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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 May 2016.

Neurotrophic tyrosine kinase, receptor, type 3

trkC, NTRK3
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: trkA, TrkB, neurotrophin-3, Brain-derived neurotrophic factor, NGF
Papers on trkC
NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States.
New
Nikiforov et al., Bologna, Italy. In Cancer, Feb 2016
RESULTS: Seven of 27 PTCs (26%) had neurotrophic tyrosine kinase receptor (NTRK) fusion oncogenes (NTRK type 3/ets variant 6 [NTRK3/ETV6], n =5; NTRK3/unknown, n = 1; and NTRK type 1/translocated promoter region, nuclear basket protein [NTRK1/TPR], n = 1), including 5 tumors that measured >2 cm and 3 that diffusely involved the entire thyroid or lobe.
Neurotrophin-3 Induces BMP-2 and VEGF Activities and Promotes the Bony Repair of Injured Growth Plate Cartilage and Bone in Rats.
New
Xian et al., Adelaide, Australia. In J Bone Miner Res, Feb 2016
NT-3 and its receptor TrkC showed the highest induction.
Identification of Targetable Kinase Alterations in Patients with Colorectal Carcinoma that are Preferentially Associated with Wild Type RAS/RAF.
New
Ladanyi et al., Kettering, United States. In Mol Cancer Res, Jan 2016
Three RTK fusions were identified: NCOA4-RET, ERBB2-GRB7, ETV6-NTRK3.
The effects of IGF-1 on Trk expressing DRG neurons with HIV-gp120-induced neurotoxicity.
New
Liu et al., Jinan, China. In Curr Hiv Res, Jan 2016
In the present study, tyrosine kinase receptor (Trk)A, TrkB, and TrkC expression in primary cultured dorsal root ganglion (DRG) neurons with gp120-induced neurotoxicity was investigated.
ALK, ROS1 and NTRK3 gene rearrangements in inflammatory myofibroblastic tumors.
New
Oda et al., Fukuoka, Japan. In Histopathology, Jan 2016
Two cases of pulmonary IMT, in a 7-year-old and a 23-year-old patient, had ETV6 gene rearrangement, and the ETV6-NTRK3 fusion transcript was confirmed in one case.
Molecular signature of salivary gland tumors: potential use as diagnostic and prognostic marker.
Review
New
Vargas et al., Piracicaba, Brazil. In J Oral Pathol Med, Jun 2015
Finally, the identification of ETV6-NTRK3 in cases previously diagnosed as uncommon acinic cell carcinomas, cystadenocarcinomas, and adenocarcinomas not otherwise specified led to the characterization of a completely new and now widely accepted entity, including, therefore, mammary analogue secretory carcinoma in the list of well-recognized salivary gland carcinomas.
The p75 neurotrophin receptor: at the crossroad of neural repair and death.
Review
New
Williams et al., Chapel Hill, United States. In Neural Regen Res, May 2015
The strong repair and pro-survival functions of neurotrophins at their primary receptors, TrkA, TrkB and TrkC, have made them attractive candidates for treatment of nervous system injury and disease.
TRKing down an old oncogene in a new era of targeted therapy.
Review
Doebele et al., Aurora, United States. In Cancer Discov, 2015
Oncogenic alterations, most commonly gene fusions, have now been detected for the genes encoding the TRKA, TRKB, and TRKC receptor tyrosine kinases across multiple tumor types.
Secretory breast carcinoma in a 41-year-old man with long-term follow-up: a special report.
Review
Yang et al., Haikou, China. In Future Oncol, 2014
ETV6-NTRK3 fusion gene is a specific genetic alteration in SBC.
Neurodevelopment. Dendrite morphogenesis depends on relative levels of NT-3/TrkC signaling.
Impact
Luo et al., Stanford, United States. In Science, 2014
We show that the neurotrophin receptor tropomyosin-related kinase C (TrkC) is required for dendritic growth and branching of mouse cerebellar Purkinje cells.
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
Impact
Mullighan et al., Memphis, United States. In N Engl J Med, 2014
Cell lines and human leukemic cells expressing ABL1, ABL2, CSF1R, and PDGFRB fusions were sensitive in vitro to dasatinib, EPOR and JAK2 rearrangements were sensitive to ruxolitinib, and the ETV6-NTRK3 fusion was sensitive to crizotinib.
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma.
Impact
St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project et al., Memphis, United States. In Nat Genet, 2014
Structural variants generating fusion genes were found in 47% of DIPGs and NBS-HGGs, with recurrent fusions involving the neurotrophin receptor genes NTRK1, NTRK2 and NTRK3 in 40% of NBS-HGGs in infants.
Mammary analog secretory carcinoma of salivary gland with high-grade histology arising in hard palate, report of a case and review of literature.
Review
Fung et al., United States. In Int J Clin Exp Pathol, 2013
This tumor shares histologic features, immunohistochemical profile, and a highly specific genetic translocation, ETV6-NTRK3, with secretory carcinoma of breast.
Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells.
Impact
Lindquist et al., Cambridge, United States. In Nat Biotechnol, 2013
Demonstrating the value of the assay, we identify ETV6-NTRK3 as a target of the FDA-approved drug crizotinib (Xalkori).
Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.
Review
Impact
Massa et al., Stanford, United States. In Nat Rev Drug Discov, 2013
One strategy to overcome these limitations is to target individual neurotrophin receptors — such as tropomyosin receptor kinase A (TRKA), TRKB, TRKC, the p75 neurotrophin receptor or sortilin — with small-molecule ligands.
Expression of neurotrophin receptors by retinoinvasive uveal melanoma.
GeneRIF
Finger et al., New York City, United States. In Melanoma Res, 2012
expression of neurotrophin receptors Pan-Trk, p75 neurotrophin receptor (p75(NTR) and ciliary neurotrophic factor receptor-alpha in ulveal melanoma does not show a role in growth.
A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation.
GeneRIF
Sorensen et al., Vancouver, Canada. In Oncogene, 2012
find that both IRS1 and kinase active IGF1R are required for ETV6-NTRK3 transformation, that tyrosine phosphorylated IRS1 is present in high molecular weight complexes with EN and IGF1R, and that EN colocalizes with IGF1R at the plasma membrane
Transcriptional regulation of TRKC by SOX2 in human embryonic stem cells.
GeneRIF
Donovan et al., Irvine, United States. In Stem Cell Res, 2012
SOX2 utilizes a specific binding motif to directly interact with the TRKC regulatory region.
Cograft of neural stem cells and schwann cells overexpressing TrkC and neurotrophin-3 respectively after rat spinal cord transection.
GeneRIF
Teng et al., Guangzhou, China. In Biomaterials, 2011
Transplantation of overexpressing neurotrophin-3-Schwann cells + trkC-neural stem cells in Gelfoam into the lesion gap immediately following injury results in significantly improved relay of the cortical motor evoked potential.
Neurotrophin receptor TrkC is an entry receptor for Trypanosoma cruzi in neural, glial, and epithelial cells.
GeneRIF
Pereiraperrin et al., Boston, United States. In Infect Immun, 2011
TrkC is implicated as a functional PDNF receptor in cell entry, independently of sialic acid recognition, mediating broad T. cruzi infection both in vitro and in vivo.
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