Recurrent fusion transcripts detected by whole-transcriptome sequencing of 120 primary breast cancer samples.
Seoul, South Korea. In Genes Chromosomes Cancer, 30 Aug 2015
Three previously reported fusions, PPP1R1B-STARD3, MFGE8-HAPL, and ETV6-NTRK3, were detected in 8.3, 3.3, and 0.8% of the 120 samples, respectively, by both deFuse and Chimerascan.
Dynamic nature of the p75 neurotrophin receptor in response to injury and disease.
Chapel Hill, United States. In J Neuroimmune Pharmacol, Dec 2014
Neurotrophins and their respective tropomyosin related kinase (Trk) receptors (TrkA, TrkB, and TrkC) and the p75 neurotrophin receptor (p75(NTR)) play a fundamental role in the development and maintenance of the nervous system making them important targets for treatment of neurodegenerative diseases.
Dependence receptors and colorectal cancer.
Lyon, France. In Gut, Nov 2014
This review will describe how receptors such as deleted in colorectal carcinoma (DCC), uncoordinated 5 (UNC5), rearranged during transfection (RET) or TrkC constrain CRC progression and how this dependence receptor paradigm may open up therapeutical perspectives.