BDNF - a key transducer of antidepressant effects.
Stockholm, Sweden. In Neuropharmacology, Mar 2016
The antidepressant-like response of ketamine is abolished in BDNF and TrkB conditional knockout mice, eEF2 kinase knockout mice, in mice carrying the BDNF met/met allele, and by intra-cortical infusions of BDNF-neutralizing antibodies.
Antidepressants for neuroprotection in Huntington's disease: A review.
Moga, India. In Eur J Pharmacol, Jan 2016
Major depression is the most common symptom among pre-symptomatic HD carriers and numerous pieces of preclinical evidence have suggested the use of antidepressants in HD not only elevates mood but also slows down the disease progression by activating different neuroprotective mechanism like BDNF/TrkB pathway, MAPK/ERK signalling, neurogenesis and Wnt signalling.
Brain-derived neurotrophic factor and its clinical implications.
Vishākhapatnam, India. In Arch Med Sci, Jan 2016
BDNF binds to its high affinity receptor TrkB (tyrosine kinase B) and activates signal transduction cascades (IRS1/2, PI3K, Akt), crucial for CREB and CBP production, that encode proteins involved in β cell survival.
Early Life Stress Effects on Glucocorticoid-BDNF Interplay in the Hippocampus.
New York City, United States. In Front Mol Neurosci, 2014
The neurotrophin and GC-signaling pathways co-exist throughout the central nervous system (CNS), particularly in the hippocampus, which has high expression levels of glucocorticoid-receptors (GR) and mineralocorticoid-receptors (MR) as well as brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase receptor B (TrkB).