Molecular beaconsmore suppliers
In Molecular Brain, 2003
... Santa Cruz Biotechnology (Santa Cruz, CA); the anti-GFP antibody was from MBL (Nagoya, Japan); the anti-phospho-Trk (Y490) was from Cell Signaling (Beverly, MA); anti-MAP2 (microtubule-associated ...
The expression of β3 -adrenoceptors and their function in the human prostate.
Hamamatsu, Japan. In Prostate, Feb 2016
Strips of human normal prostate or BPH were suspended in organ baths and exposed to isoproterenol, dobutamine, procaterol, and TRK-380 to investigate their relaxant effects on KCl-induced contractions, and their inhibitory effects on electrical field stimulation (EFS)-induced contractions.
Modulation of neurotrophic signaling pathways by polyphenols.
Shīrāz, Iran. In Drug Des Devel Ther, Dec 2015
Assessment of underlying mechanisms, especially in PC12 neuronal-like cells, reveals that direct agonistic effect on tropomyosin receptor kinase (Trk) receptors, the main receptors of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) explains the action of few polyphenols such as 7,8-dihydroxyflavone.
Entrectinib: a potent new TRK, ROS1, and ALK inhibitor.
Edegem, Belgium. In Expert Opin Investig Drugs, Nov 2015
AREAS COVERED: This review outlines the pharmacokinetics, pharmacodynamics, mechanism of action, safety, tolerability, pre-clinical studies and clinical trials of entrectinib, a promising novel agent for the treatment of advanced solid tumors with molecular alterations of Trk-A, B and C, ROS1 or ALK.
NGF/TrkA Signaling as a Therapeutic Target for Pain.
Japan. In Pain Pract, Sep 2015
It is now known that NGF is also associated with Alzheimer's disease and intractable pain, and hence, it, along with its high-affinity receptor, tropomyosin receptor kinase (Trk) A, is considered to be 1 of the new targets for therapies being developed to treat these diseases.
Neurologic Regulation and Orthodontic Tooth Movement.
In Front Oral Biol, 2014
The periodontium is a highly innervated structure that also provides the necessary trophic factors, such as nerve growth factor, which promote neuronal survival, maintenance and axonal growth, via interaction with specific nerve surface receptors, such as TrkA.
The structure of the KtrAB potassium transporter.
Porto, Portugal. In Nature, 2013
In bacteria, archaea, fungi and plants the Trk, Ktr and HKT ion transporters are key components of osmotic regulation, pH homeostasis and resistance to drought and high salinity.
NGF causes TrkA to specifically attract microtubules to lipid rafts.
More papers using
Palmerston North, New Zealand. In Plos One, 2011
The data indicated that TrkA and p75NTR partition into membrane rafts by different mechanisms, and that the fraction of TrkA that associates with detergent resistant membranes is internalized but does not directly form signaling endosomes.