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Zinc finger protein 36

tristetraprolin, TIS11
acts as a transcriptional activator [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: caspase-3, CAN, p38, V1a, MAPK
Papers on tristetraprolin
Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements.
Lykke-Andersen et al., San Diego, United States. In Rna, Feb 2016
UNASSIGNED: The zinc finger protein tristetraprolin (TTP) promotes translation repression and degradation of mRNAs containing AU-rich elements (AREs).
Negative Feed-forward Control of Tumor Necrosis Factor (TNF) by Tristetraprolin (ZFP36) Is Limited by the Mitogen-activated Protein Kinase Phosphatase, Dual-specificity Phosphatase 1 (DUSP1): IMPLICATIONS FOR REGULATION BY GLUCOCORTICOIDS.
Newton et al., Calgary, Canada. In J Biol Chem, Feb 2016
The 3'-untranslated region of the TNF transcript contains AU-rich elements (AREs) that are targeted by the RNA-binding protein, tristetraprolin (also known as zinc finger protein 36 (ZFP36)), which is itself up-regulated by inflammatory stimuli, to promote mRNA degradation.
Glioma: Tryptophan Catabolite and Melatoninergic Pathways link microRNA, 14-3-3, Chromosome 4q35, Epigenetic Processes and other Glioma Biochemical Changes.
Mazzoccoli et al., London, United Kingdom. In Curr Pharm Des, Jan 2016
A diverse array of data pertaining to glioma can be linked to these pathways, including changes in miRNAs, epigenetic processes, estrogen receptors, 14-3-3, chromosome 4q35, neurotrophins, tristetraprolin and the N-acetylserotonin (NAS)/melatonin ratio.
Tristetraprolin induces cell cycle arrest in breast tumor cells through targeting AP-1/c-Jun and NF-κB pathway.
Liu et al., Chongqing, China. In Oncotarget, Jan 2016
However, the underlying mechanisms of cancer cell proliferation, especially those regulated by the RNA binding protein tristetraprolin (TTP), are not completely understood.
Sodium butyrate down-regulates tristetraprolin-mediated cyclin B1 expression independent of the formation of processing bodies.
Xiao et al., Wenzhou, China. In Int J Biochem Cell Biol, Dec 2015
The underlying mechanism is related to the destabilization of its mRNA by tristetraprolin, which is up-regulated in response to sodium butyrate.
Resveratrol Induces Glioma Cell Apoptosis through Activation of Tristetraprolin.
Kang et al., Chinju, South Korea. In Mol Cells, Dec 2015
Tristetraprolin (TTP) is an AU-rich elements (AREs)-binding protein, which regulates the decay of AREs-containing mRNAs such as proto-oncogenes, anti-apoptotic genes and immune regulatory genes.
RNA-stabilizing proteins as molecular targets in cardiovascular pathologies.
Krishnamurthy et al., Houston, United States. In Trends Cardiovasc Med, Nov 2015
Many mRNA binding proteins have been discovered to date, which either stabilize (HuR/HuA, HuB, HuC, HuD) or destabilize (AUF1, tristetraprolin, KSRP) the target transcripts.
Tristetraprolin and its role in regulation of airway inflammation.
Ammit et al., Sydney, Australia. In Mol Pharmacol, Apr 2015
We propose that an alternative strategy may be to target an anti-inflammatory molecule farther downstream of p38 MAPK, i.e., tristetraprolin (TTP).
Mammalian target of rapamycin coordinates iron metabolism with iron-sulfur cluster assembly enzyme and tristetraprolin.
Wang et al., China. In Nutrition, 2014
Moreover, mTOR is reported to control iron metabolism through modulation of tristetraprolin expression.
Phylogenetic distribution and evolution of the linked RNA-binding and NOT1-binding domains in the tristetraprolin family of tandem CCCH zinc finger proteins.
Perera et al., United States. In J Interferon Cytokine Res, 2014
In humans, the tristetraprolin or TTP family of CCCH tandem zinc finger (TZF) proteins comprises 3 members, encoded by the genes ZFP36, ZFP36L1, and ZFP36L2.
Control of pro-angiogenic cytokine mRNA half-life in cancer: the role of AU-rich elements and associated proteins.
Pagès et al., Genova, Italy. In J Interferon Cytokine Res, 2014
Some of these RNA-binding proteins, such as tristetraprolin (TTP), ARE RNA-binding protein 1, and KH-type splicing regulatory protein, normally promote mRNA degradation.
mTOR regulates cellular iron homeostasis through tristetraprolin.
Ardehali et al., Chicago, United States. In Cell Metab, 2012
Mechanistic studies identify tristetraprolin (TTP), a protein involved in anti-inflammatory response, as the downstream target of mTOR that binds to and enhances degradation of TfR1 mRNA.
Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production.
Karin et al., San Diego, United States. In J Immunol, 2012
Expression of IL-10 is regulated posttranscriptionally by RNA-binding protein tristetraprolin (TTP), which destabilizes IL-10 mRNA in activated macrophages.
Expression of proviral integration site for Moloney murine leukemia virus 1 (Pim-1) is post-transcriptionally regulated by tristetraprolin in cancer cells.
Cho et al., Ulsan, South Korea. In J Biol Chem, 2012
TTP post-transcriptionally down-regulates Pim-1 expression and that the overexpression of TTP may contribute to tumor suppression in part by down-regulating Pim-1 expression.
Tristetraprolin impairs myc-induced lymphoma and abolishes the malignant state.
Cleveland et al., Jupiter, United States. In Cell, 2012
TTP suppression is a hallmark of cancers with MYC involvement, and restoring TTP impairs Myc-induced lymphomagenesis and abolishes maintenance of the malignant state.
Myeloid-specific tristetraprolin deficiency in mice results in extreme lipopolysaccharide sensitivity in an otherwise minimal phenotype.
Blackshear et al., United States. In J Immunol, 2012
Myeloid cell TTP plays a critical role in protecting mice against lipopolysaccharide (LPS)-induced septic shock.
ZFP36 expression impairs glioblastoma cell lines viability and invasiveness by targeting multiple signal transduction pathways.
Zanocco-Marani et al., Reggio nell'Emilia, Italy. In Cell Cycle, 2012
New ZFP36 targets are the kinases PIM1 and PIM3 and X-linked inhibitor of apoptosis protein (XIAP).
Involvement of microRNA in AU-rich element-mediated mRNA instability.
Han et al., Los Angeles, United States. In Cell, 2005
The role of miR16 in ARE-RNA decay is sequence-specific and requires the ARE binding protein tristetraprolin (TTP).
Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin.
Blackshear et al., United States. In Science, 1998
Tristetraprolin (TTP), the prototype of a class of Cys-Cys-Cys-His (CCCH) zinc finger proteins, inhibited TNF-alpha production from macrophages by destabilizing its messenger RNA.
A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency.
Blackshear et al., Durham, United States. In Immunity, 1996
Tristetraprolin (TTP) is a widely expressed potential transcription factor that contains two unusual CCCH zinc fingers and is encoded by the immediate-early response gene, Zfp-36.
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