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SERTA domain containing 2

TRIP-Br2, SEI-2, SERTAD2
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Top mentioned proteins: TRIP, SEI-1, PCNA, E2F1, Transcription Factor DP1
Papers on TRIP-Br2
Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance.
Impact
Kulkarni et al., Boston, United States. In Nat Med, 2013
Here we describe a new transcription co-regulator for adiposity and energy metabolism, SERTA domain containing 2 (TRIP-Br2, also called SERTAD2).
I-mfa domain proteins specifically interact with SERTA domain proteins and repress their transactivating functions.
Eizuru et al., Kagoshima, Japan. In Biochimie, 2011
In addition, I-mfa also specifically interacts with other SERTA domain-containing proteins, including SEI-2, SEI-3, SERTAD3 and SERTAD4, through its I-mfa domain in vivo.
TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors.
GeneRIF
Hsu et al., Boston, United States. In J Transl Med, 2008
TRIP-Br2 is frequently overexpressed in both cancer cell lines and multiple human tumors.
CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein.
GeneRIF
Hsu et al., Boston, United States. In J Biol Chem, 2008
CRM1-mediated nuclear export may be required for the proper execution of ubiquitin-proteasome-dependent degradation of TRIP-Br2
Exploiting the TRIP-Br family of cell cycle regulatory proteins as chemotherapeutic drug targets in human cancer.
Hsu et al., Singapore, Singapore. In Cancer Biol Ther, 2007
TRIP-Br1 and TRIP-Br2 are potent cell growth promoting factors that function as components of the E2F1/DP1 transcription complex to integrate positive growth signals provided by PHD zinc finger- and/or bromodomain-containing transcription factors.
Transcriptional and subcellular regulation of the TRIP-Br family.
Yang et al., T'ai-chung-shih, Taiwan. In Gene, 2007
Finally, while all three TRIP-Brs are localized to the nucleus, TRIP-Br2 and TRIP-Br3 are also present in the cytoplasm through interaction with CRM1.
CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation.
Yoshida et al., Kawasaki, Japan. In J Biol Chem, 2006
Like TRIP-Br1/p34(SEI-1) and TRIP-Br2 (SEI-2), the transactivation domain of CDCA4 was mapped within C-terminal acidic region 175-241.
Celecoxib reduces microvessel density in patients treated with nasopharyngeal carcinoma and induces changes in gene expression.
Goh et al., Singapore, Singapore. In Ann Oncol, 2006
Down-regulated genes included cell cycle regulation-related (cyclin-dependent kinase 2, YES1), transcription factor (TRIP-Br2), whereas the antigen processing and presentation-related gene HLA-DM B was up-regulated.
The TRIP-Br family of transcriptional regulators is essential for the execution of cyclin E-mediated cell cycle progression.
Hsu et al., Singapore, Singapore. In Cell Cycle, 2006
To further elucidate the functional role(s) of the TRIP-Br proteins in mitogenic signaling, we have developed the synthetic DNA enzymes E-Br1 and E-Br2 to specifically knock down the serum-inducible expression of TRIP-Br1 and TRIP-Br2, respectively, in WI-38 human fibroblasts in culture, as well as generated TRIP-Br2 null primary embryonic fibroblasts from a novel TRIP-Br2 knockout mouse model.
SEI family of nuclear factors regulates p53-dependent transcriptional activation.
Fukunaga et al., Suita, Japan. In Genes Cells, 2005
SEI family proteins, p34SEI-1 and SEI-2(TRIP-Br2), are nuclear factors that are implicated in cell cycle regulation through interaction with CDK4/CyclinD and E2F-1/DP-1 complexes.
TRIP-Br links E2F to novel functions in the regulation of cyclin E expression during cell cycle progression and in the maintenance of genomic stability.
Hsu et al., Singapore, Singapore. In Cell Cycle, 2004
The TRIP-Br family of transcriptional regulators (TRIP-Br1 and TRIP-Br2) has been proposed to function at E2F-responsive promoters to integrate regulatory signals provided by PHD zinc finger- and/or bromodomain-containing transcription factors.
Confirmation of linkage and refinement of the RP28 locus for autosomal recessive retinitis pigmentosa on chromosome 2p14-p15 in an Indian family.
Blanton et al., Bengaluru, India. In Mol Vis, 2004
Of 15 genes reported in the MCR, 14 genes (KIAA0903, OTX1, MDH1, UGP2, VPS54, PELI1, HSPC159, FLJ20080, TRIP-Br2, SLC1A4, KIAA0582, RAB1A, ACTR2, and SPRED2) are either expressed in the eye or retina.
The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatus.
Bourbon et al., Toulouse, France. In Genetics, 2002
The TARA proteins share evolutionarily conserved motifs with several recently characterized mammalian nuclear proteins, including the cyclin-dependent kinase regulator TRIP-Br1/p34(SEI-1), the related protein TRIP-Br2/Y127, and RBT1, a partner of replication protein A. These data raise the possibility that TARA-alpha/-beta play a role in integrating chromatin structure with cell cycle regulation.
TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1.
Bonventre et al., United States. In Embo J, 2001
TRIP-Br1 and the related protein TRIP-Br2 possess transactivation domains.
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