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Tripartite motif containing 29

TRIM29, Tripartite Motif-Containing 29
The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Trim, HAD, p53, POLYMERASE, CAN
Papers on TRIM29
ATDC/TRIM29 Drives Invasive Bladder Cancer Formation through miRNA-Mediated and Epigenetic Mechanisms.
Simeone et al., Ann Arbor, United States. In Cancer Res, Jan 2016
ATDC/TRIM29 is a highly expressed gene in several lethal tumor types, including bladder tumors, but its role as a pathogenic driver has not been established.
ATDC (Ataxia Telangiectasia Group D Complementing) Promotes Radioresistance through an Interaction with the RNF8 Ubiquitin Ligase.
Simeone et al., Ann Arbor, United States. In J Biol Chem, Dec 2015
The ataxia telangiectasia group D complementing gene (ATDC, also called TRIM29) is highly expressed in many malignancies.
Tripartite motif-containing 29 as a novel biomarker in non-small cell lung cancer.
Zhang et al., Jinan, China. In Oncol Lett, Oct 2015
UNASSIGNED: Tripartite motif-containing 29 (TRIM29) is a member of the tripartite motif (TRIM) protein family.
TRIM29 regulates the p63-mediated pathway in cervical cancer cells.
Hatakeyama et al., Sapporo, Japan. In Biochim Biophys Acta, Oct 2015
Here, we show that a member of the tripartite motif protein family, TRIM29, is required for regulation of the p63-mediated pathway in cervical cancer cells.
Downregulation of miR-432 activates Wnt/β-catenin signaling and promotes human hepatocellular carcinoma proliferation.
Wang et al., Guangzhou, China. In Oncotarget, May 2015
Furthermore, miR-432 directly targeted and suppressed multiple regulators of the Wnt/β-catenin signaling cascade, including LRP6, TRIM29 and Pygo2, which subsequently deactivated Wnt/β-catenin signaling pathway.
Proteomic analysis of oral cavity squamous cell carcinoma specimens identifies patient outcome-associated proteins.
Lim et al., Detroit, United States. In Arch Pathol Lab Med, Apr 2015
Reduction of DSP, PKP1, and TRIM29 was associated with significantly shorter time to onset of distant metastasis.
Cross-platform meta-analysis of multiple gene expression profiles identifies novel expression signatures in acquired anthracycline-resistant breast cancer.
Kim et al., South Korea. In Oncol Rep, Apr 2015
The PPI network indicated that proteins encoded by TRIM29, VTN, CCNA1, and karyopherin α 5 (KPNA5) participated in a significant number of interactions.
ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis.
Simeone et al., Ann Arbor, United States. In Genes Dev, Feb 2015
Here we describe a novel mouse model expressing ataxia telangiectasia group D complementing gene (ATDC, also known as TRIM29 [tripartite motif 29]) that, in the presence of oncogenic KRAS, accelerates pancreatic intraepithelial neoplasia (PanIN) formation and the development of invasive and metastatic cancers.
Silencing of tripartite motif (TRIM) 29 inhibits proliferation and invasion and increases chemosensitivity to cisplatin in human lung squamous cancer NCI-H520 cells.
Li et al., Beijing, China. In Thorac Cancer, 2015
BACKGROUND: TRIM29 belongs to the tripartite motif (TRIM) protein family.
TRIM29 functions as an oncogene in gastric cancer and is regulated by miR-185.
Xiang et al., Wuhan, China. In Int J Clin Exp Pathol, 2014
Tripartite motif-containing 29 (TRIM29) belongs to TRIM family of transcription factors and may function as an oncogene or a tumor suppressor depending on the tumor types.
TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins.
Wang et al., Nanchang, China. In Plos One, 2014
In an effort to profile the expression patterns of TRIM superfamily in several non-small cell lung cancer (NSCLC) cell lines, we found that the expression of 10 TRIM genes including TRIM3, TRIM7, TRIM14, TRIM16, TRIM21, TRIM22, TRIM29, TRIM59, TRIM66 and TRIM70 was significantly upregulated in NSCLC cell lines compared with the normal human bronchial epithelial (HBE) cell line, whereas the expression of 7 other TRIM genes including TRIM4, TRIM9, TRIM36, TRIM46, TRIM54, TRIM67 and TRIM76 was significantly down-regulated in NSCLC cell lines compared with that in HBE cells.
TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin.
Hatakeyama et al., Sapporo, Japan. In Nat Commun, 2014
Here we show that a member of the tripartite motif protein family, TRIM29, is a histone-binding protein responsible for DNA damage response (DDR).
TRIM29 suppresses TWIST1 and invasive breast cancer behavior.
Brown et al., Sapporo, Japan. In Cancer Res, 2014
TRIM29 (ATDC) exhibits a contextual function in cancer, but seems to exert a tumor-suppressor role in breast cancer.
Ultraviolet radiation effects on the proteome of skin cells.
Woods et al., Hobart, Australia. In Adv Exp Med Biol, 2012
Others changes included altered cytokeratin and cytoskeletal proteins with enhanced expression of TRIM29 as the keratinocytes regenerate.
Significance of TRIM29 and β-catenin expression in non-small-cell lung cancer.
Yu et al., Wuxi, China. In J Chin Med Assoc, 2012
The interaction between TRIM29 and beta-catenin may participate in the development of lung squamous cell carcinoma.
TRIM29 functions as a tumor suppressor in nontumorigenic breast cells and invasive ER+ breast cancer.
Bernard et al., Salt Lake City, United States. In Am J Pathol, 2012
results suggest that loss of TRIM29 expression in normal breast luminal cells can contribute to malignant transformation and lead to progression of ER+ breast cancer in premenopausal women.
TRIM29 negatively regulates p53 via inhibition of Tip60.
Hatakeyama et al., Sapporo, Japan. In Biochim Biophys Acta, 2011
Data show that overexpression of TRIM29 promoted degradation and changed localization of Tip60 and reduced acetylation of p53 at lysine 120 by Tip60, resulting in enhancement of cell growth and transforming activity.
Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein.
Seto et al., Tampa, United States. In J Biol Chem, 2011
Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein
Proteomic profiling of human keratinocytes undergoing UVB-induced alternative differentiation reveals TRIpartite Motif Protein 29 as a survival factor.
Toussaint et al., Namur, Belgium. In Plos One, 2009
TRIM29 allows keratinocytes to enter a protective alternative differentiation process rather than die massively after stress.
Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization.
Simeone et al., Ann Arbor, United States. In Cancer Cell, 2009
ATDC was found to stabilize beta-catenin via ATDC-induced effects on the Disheveled-2 protein, a negative regulator of glycogen synthase kinase 3beta in the Wnt/beta-catenin signaling pathway.
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