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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

T cell receptor associated transmembrane adaptor 1

Trim, TRIM6, TRAT1
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: CAN, TRIM5alpha, Ubiquitin, TRIM34, TRIM32
Papers on Trim
Thrombelastometric results and platelet function during pregnancy in women receiving low molecular weight heparin with a history of recurrent/late abortion - A retrospective analysis.
New
Csorba et al., Hanau am Main, Germany. In Clin Hemorheol Microcirc, Nov 2015
TF-induced coagulation activation resulted in statistically significantly decreased mean clot-formation-times (CFT) (Trim I: 108.9 ± 5.2 S to Trim III; 81.7 ± 5.4 S; p = 0.001), whereas after contact activation (Intem-S: Trim I: 70.1 ± 4.0 S to Trim III: 65.4 ± 6.8; n.s.) CFT remained unchanged.
Lin41/Trim71 is essential for mouse development and specifically expressed in postnatal ependymal cells of the brain.
Wulczyn et al., Berlin, Germany. In Front Cell Dev Biol, 2014
Lin41/Trim71 is a heterochronic gene encoding a member of the Trim-NHL protein family, and is the original, genetically defined target of the microRNA let-7 in C. elegans.
Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71.
Kolanus et al., Bonn, Germany. In Sci Rep, 2014
Using Trim71, one of two members of the Tripartite motif (Trim) protein family with RNA binding activity expressed in murine ES cells, we demonstrate that Trim71 is not involved in regulatory networks of pluripotency but regulates neural differentiation.
Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response.
Impact
García-Sastre et al., New York City, United States. In Immunity, 2014
Here we show that TRIM6, a member of the E3-ubiquitin ligase tripartite motif (TRIM) family of proteins, interacted with IKKε and promoted induction of IKKε-dependent ISGs.
Anti-HIV-1 activity of Trim 37.
Mansky et al., Minneapolis, United States. In J Gen Virol, 2014
Trim 5α was the first member of the tripartite motif (TRIM) family of proteins that was identified to potently restrict human immunodeficiency virus type 1 (HIV-1) replication.
Binding of the rhesus TRIM5α PRYSPRY domain to capsid is necessary but not sufficient for HIV-1 restriction.
Diaz-Griffero et al., United States. In Virology, 2014
In support of this hypothesis, we showed that some human tripartite motif proteins bind the HIV-1 capsid but do not restrict HIV-1 infection, such as human TRIM6 and TRIM34.
Antidepressant use and new-onset diabetes: a systematic review and meta-analysis.
Review
Sambamoorthi et al., Morgantown, United States. In Diabetes Metab Res Rev, 2013
Egger's regression test and the Trim and Fill method were utilized to detect the presence of any potential publication bias.
Novel function of Trim44 promotes an antiviral response by stabilizing VISA.
Sun et al., Hefei, China. In J Immunol, 2013
In this study, we demonstrate that tripartite motif (Trim)44 interacts with VISA and promotes VISA-mediated antiviral responses.
The CCR4 deadenylase acts with Nanos and Pumilio in the fine-tuning of Mei-P26 expression to promote germline stem cell self-renewal.
Simonelig et al., Montpellier, France. In Stem Cell Reports, 2012
mei-P26 encodes a protein of the Trim-NHL tumor suppressor family that has conserved functions in stem cell lineages.
Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity.
Engelman et al., Boston, United States. In Plos Pathog, 2012
NUP153(C) fused to the effector domains of the rhesus Trim5α restriction factor (Trim-NUP153(C)) potently restricted HIV-1, providing an intracellular readout for the NUP153(C)-CA interaction during retroviral infection.
Elevated rate of fixation of endogenous retroviral elements in Haplorhini TRIM5 and TRIM22 genomic sequences: impact on transcriptional regulation.
Hunter et al., Atlanta, United States. In Plos One, 2012
All genes in the TRIM6/TRIM34/TRIM5/TRIM22 locus are type I interferon inducible, with TRIM5 and TRIM22 possessing antiviral properties.
Tripartite motif containing 28 (Trim28) can regulate cell proliferation by bridging HDAC1/E2F interactions.
Cress et al., Tampa, United States. In J Biol Chem, 2012
This surprising observation suggests that Trim 28 may have anti-proliferative activity within tumors.
MiRNA need a TRIM regulation of miRNA activity by Trim-NHL proteins.
Review
Rybak et al., Berlin, Germany. In Adv Exp Med Biol, 2009
Trim-NHL proteins are defined by RING, B-Box and Coiled-coil protein motifs (referred to collectively as the Trim domain) coupled to an NHL domain.
SIT and TRIM determine T cell fate in the thymus.
GeneRIF
Simeoni et al., Magdeburg, Germany. In J Immunol, 2008
TRIM and Src homology domain-containing tyrosine phosphatase 2-interacting transmembrane adaptor protein (SIT) regulate cell fate of developing thymocytes and are essential regulators of central tolerance.
Human leukocyte antigen class I-restricted immunosuppression by human CD8+ regulatory T cells requires CTLA-4-mediated interaction with dendritic cells.
GeneRIF
Gaston et al., Cambridge, United Kingdom. In Hum Immunol, 2008
TRIM acts to chaperone CTLA-4 transport to the cell surface; this function would be required to account for the phenotypic and functional properties of CD8(+) Tregs.
Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage.
Impact
Knoblich et al., Vienna, Austria. In Nature, 2008
Whereas neuroblasts segregate the Trim-NHL (tripartite motif and Ncl-1, HT2A and Lin-41 domain)-containing protein Brain tumour (Brat) into one of the two daughter cells, ovarian stem cells are regulated by an extracellular signal from the surrounding stem cell niche.
CTLA-4 trafficking and surface expression.
Review
Schneider et al., Cambridge, United Kingdom. In Trends Immunol, 2008
Recently, several signalling molecules such as Trim, PLD, ARF-1 and TIRC7 have been described to be involved in the transport of CTLA-4 to the cell surface.
Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains.
GeneRIF
Sodroski et al., Boston, United States. In J Virol, 2006
heterologous RING, B-box 2, and CC domains from related TRIM proteins can functionally substitute for TRIM5alpha(rh) domains.
Normal T-cell development and immune functions in TRIM-deficient mice.
GeneRIF
Simeoni et al., Magdeburg, Germany. In Mol Cell Biol, 2006
TRIM is dispensable for T-cell development and peripheral immune functions.
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