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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

T-complex protein 1

TRIC, CCT, TCP-1
The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: CAN, ACID, Actin, HAD, V1a
Papers using TRIC antibodies
Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.
Supplier
Parsons Maddy, In PLoS ONE, 2010
... G GGC AGT CCT ACA GGT TCA TCA ACT CGA GTT GAT GAA CCT GTA GGA CTG CTT TTT G) were from Sigma; DyLight 549 conjugated goat anti-mouse IgG (H+L) was from Thermo Scientific; Fibronectin and recombinant HGF ...
Actin-dependent dynamics of keratin filament precursors
Supplier
Cordes Nils, In PLoS ONE, 2008
... G GAT CCC AGT ACT CGT CCT GGT CTT C) into vector pECFP-N1 (Clontech Laboratories) ...
Papers on TRIC
Photodynamic therapy in VEGF inhibition non-responders-pharmacogenetic study in age-related macular degeneration assessed with swept-source optical coherence tomography.
New
Wylegala et al., Katowice, Poland. In Photodiagnosis Photodyn Ther, Feb 2016
Overall mean following measured parameters were obtained at baseline/day 7/Month 3/Month 6 (significant changes from baseline are marked with asterisk): GLD - 3825±1301μm/3901±1579μm/3861±1463μm/3925±1523μm; CSMT - 405±203μm/434±257μm*/321±163μm*/295±157* μm; CCT 235±103μm/278±157* μm/211±113μm*/201±107* μm; BCVA 49.3±12.5/43.2±14.2*/49.6±11.6/48.7±12.2
ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.
New
Impact
Parker et al., Boulder, United States. In Cell, Feb 2016
Moreover, multiple ATP-driven machines affect stress granules differently, with the CCT complex inhibiting stress granule assembly, while the MCM and RVB complexes promote stress granule persistence.
An immune regulatory CCT repeat containing oligodeoxynucleotide capable of causing hair loss in male mice.
New
Yu et al., Changchun, China. In Hum Exp Toxicol, Feb 2016
UNASSIGNED: An oligodeoxynucleotide with CCT repeats (CCT ODN) has been found in our previous study to selectively downregulate Toll-like receptor 7/9 (TLR7/9)-mediated immune responses both in vitro and in vivo.
Computational Discovery of Pathway-Level Genetic Vulnerabilities in Non-Small-Cell Lung Cancer.
New
Marcotte et al., Austin, United States. In Bioinformatics, Feb 2016
In particular, many NSCLC cell lines were especially sensitive to loss of components of the LSm2-8 protein complex or the CCT/TRiC chaperonin.
Allosteric Mechanisms in Chaperonin Machines.
New
Impact
Horovitz et al., Israel. In Chem Rev, Feb 2016
Here, we focus on the GroEL/GroES chaperonin system from Escherichia coli and, to a lesser extent, on the more poorly characterized eukaryotic chaperonin CCT/TRiC.
Membrane lipid compositional sensing by the inducible amphipathic helix of CCT.
Review
New
Cornell, Botswana. In Biochim Biophys Acta, Jan 2016
We explore the function and mechanism of sensing by the lipid biosynthetic enzyme, CTP: phosphocholine cytidylyltransferase (CCT).
Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells.
New
Yu et al., Shanghai, China. In Cancer Lett, Jan 2016
UNASSIGNED: CCT3 was one of the subunits of molecular chaperone CCT/TRiC complex, which plays a central role in maintaining cellular proteostasis.
xTract: software for characterizing conformational changes of protein complexes by quantitative cross-linking mass spectrometry.
New
Impact
Aebersold et al., Zürich, Switzerland. In Nat Methods, Dec 2015
We used the method to detect conformational changes in two model systems: firefly luciferase and the bovine TRiC complex.
New and notable ion-channels in the sarcoplasmic/endoplasmic reticulum: do they support the process of intracellular Ca(2+) release?
Review
New
Sitsapesan et al., Kyoto, Japan. In J Physiol, Sep 2015
We discuss the possible role of SR K(+) channels and, in parallel, detail the known biochemical and biophysical properties of the trimeric intracellular cation (TRIC) proteins and their possible biological and pathophysiological roles in ER/SR Ca(2+) release.
Time-restricted feeding attenuates age-related cardiac decline in Drosophila.
New
Impact
Panda et al., Los Angeles, United States. In Science, Apr 2015
We used temporal gene expression profiling and validation through classical genetics to identify the TCP-1 ring complex (TRiC) chaperonin, the mitochondrial electron transport chain complexes, and the circadian clock as pathways mediating the benefits of TRF.
Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.
New
Impact
Bozdech et al., Singapore, Singapore. In Science, Feb 2015
We analyzed the in vivo transcriptomes of 1043 P. falciparum isolates from patients with acute malaria and found that artemisinin resistance is associated with increased expression of unfolded protein response (UPR) pathways involving the major PROSC and TRiC chaperone complexes.
Penicillium excelsum sp. nov from the Brazil Nut Tree Ecosystem in the Amazon Basin'.
Frisvad et al., Campinas, Brazil. In Plos One, 2014
The holotype of P. excelsum is CCT 7772, while ITAL 7572 and IBT 31516 are cultures derived from the holotype.
An Updated Review on the Genetics of Primary Open Angle Glaucoma.
Review
Chalam et al., Riyadh, Saudi Arabia. In Int J Mol Sci, 2014
Quantitative traits related to POAG pathogenesis such as intra-ocular pressure (IOP), vertical cup/disc ratio (VCDR), optic disc area, and central corneal thickness (CCT) are highly heritable, and likely to be influenced at least in part by genes and show substantial variation in human populations.
[GLOBULAR ACTIN IS THE PARTIALLY INTRINSICALLY DISORDERED PROTEIN WITH QUASI-STATIONARY STRUCTURE].
Review
Turoverov et al., In Tsitologiia, 2014
In vivo this state occurs as a result of complex energy-consuming post-translational folding processes including chaperone Hsp70, prefoldin and CCT complex, providing the formation of the native structure stabilized by Ca2+ and ATP.
Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis.
Review
Tweardy et al., Houston, United States. In Int J Mol Sci, 2014
We further summarize and highlight the emerging the role of chaperonin TRiC (T-complex protein-1 ring complex, also known as CCT) in the development and progression of cancer mediated through its critical interactions with oncogenic clients that modulate growth deregulation, apoptosis, and genome instability in cancer cells.
Tricellulin expression in normal and neoplastic human pancreas.
GeneRIF
Kiss et al., Budapest, Hungary. In Histopathology, 2012
the tricellulin expression profile in normal and neoplastic human pancreas
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
GeneRIF
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
A look at tricellulin and its role in tight junction formation and maintenance.
Review
GeneRIF
Brito et al., Lisbon, Portugal. In Eur J Cell Biol, 2011
tricellulin and its role in tight junction formation and maintenance
TCP1 positively regulates the expression of DWF4 in Arabidopsis thaliana.
GeneRIF
Li et al., Lanzhou, China. In Plant Signal Behav, 2011
TCP1 positively regulates BR biosynthesis via its direct regulation of the transcription of DWF4.
Evidence of tricellulin expression by immune cells, particularly microglia.
GeneRIF
Brito et al., Lisbon, Portugal. In Biochem Biophys Res Commun, 2011
the expression of tricellulin both in microglia and in the stomach immune cells point to a possible role of this new tight junctions protein in the immune system.
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