Allosteric Mechanisms in Chaperonin Machines.
Israel. In Chem Rev, Feb 2016
Here, we focus on the GroEL/GroES chaperonin system from Escherichia coli and, to a lesser extent, on the more poorly characterized eukaryotic chaperonin CCT/TRiC.
An Updated Review on the Genetics of Primary Open Angle Glaucoma.
Riyadh, Saudi Arabia. In Int J Mol Sci, 2014
Quantitative traits related to POAG pathogenesis such as intra-ocular pressure (IOP), vertical cup/disc ratio (VCDR), optic disc area, and central corneal thickness (CCT) are highly heritable, and likely to be influenced at least in part by genes and show substantial variation in human populations.
Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis.
Houston, United States. In Int J Mol Sci, 2014
We further summarize and highlight the emerging the role of chaperonin TRiC (T-complex protein-1 ring complex, also known as CCT) in the development and progression of cancer mediated through its critical interactions with oncogenic clients that modulate growth deregulation, apoptosis, and genome instability in cancer cells.