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Tribbles homolog 1

TRIB1, C8FW, TRB1, Tribbles homolog, Skip1
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TRB3, TRIB2, HAD, V1a, Insulin
Papers on TRIB1
A COL17A1 Splice-Altering Mutation Is Prevalent in Inherited Recurrent Corneal Erosions.
Vincent et al., Auckland, New Zealand. In Ophthalmology, Feb 2016
Two variants segregated in 06NZ-TRB1 with ERED: COL17A1 c.3156C→T and DNAJC9 c.334G→A.
Complementary activities of TELOMERE REPEAT BINDING proteins and Polycomb Group complexes in transcriptional regulation of target genes.
Turck et al., Köln, Germany. In Plant Cell, Jan 2016
We show that TRB1 binds to thousands of genomic sites containing telobox-related cis-elements with a significant increase of sites and strength of binding in the lhp1 background.
Transcriptome profiling of human FoxP3(+) regulatory T cells.
Shevach et al., Bethesda, United States. In Hum Immunol, Jan 2016
Notably, a number of yet uncharacterized genes (RTKN2, LAYN, UTS2, CSF2RB, TRIB1, F5, CECAM4, CD70, ENC1 and NKG7) were identified and validated as being differentially expressed in human Tregs.
Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs.
Valladares-Salgado et al., Houston, United States. In Sci Rep, Dec 2015
Genome-wide significant signals were observed in or near CELSR2, ZNF259/APOA5, KANK2/DOCK6 and NCAN/MAU2 for total cholesterol, LPL, ABCA1, ZNF259/APOA5, LIPC and CETP for HDL cholesterol, CELSR2, APOB and NCAN/MAU2 for LDL cholesterol, and GCKR, TRIB1, ZNF259/APOA5 and NCAN/MAU2 for triglycerides.
The role of Trib1 in myeloid leukaemogenesis and differentiation.
Nakamura, Tokyo, Japan. In Biochem Soc Trans, Nov 2015
Tribbles homolog 1 (Trib1) was identified as a common integration site of the Homeobox a9 (Hoxa9)/murine ecotropic virus integration site 1 (Meis1) retrovirus in acute myeloid leukaemia (AML).
Tribbles-1: a novel regulator of hepatic lipid metabolism in humans.
Rader et al., Philadelphia, United States. In Biochem Soc Trans, Nov 2015
The protein tribbles-1, encoded by the gene TRIB1, is increasingly recognized as a major regulator of multiple cellular and physiological processes in humans.
Deciphering the role of TRIB1 in regulatory T-cells.
Brouard et al., Nantes, France. In Biochem Soc Trans, Nov 2015
We reported on the overexpression of tribbles-1 (TRIB1) in Tregs compared with their counterpart naive T-cells and that TRIB1 interacts with the master molecule of Tregs, forkhead box P3 (FOXP3), a transcription factor essential for Treg suppressive activity.
The role of TRIB1 in lipid metabolism; from genetics to pathways.
Nakayama et al., Tochigi, Japan. In Biochem Soc Trans, Nov 2015
Mammalian tribbles homologue 1 (TRIB1) is a human locus, the downstream linkage disequilibrium (LD) block of which affects plasma low-density lipoprotein (LDL)-associated cholesterol, triglyceride (TG) levels and CAD across multiple ethnic groups.
Tribbles in normal and malignant haematopoiesis.
Pear et al., Philadelphia, United States. In Biochem Soc Trans, Nov 2015
The three mammalian Tribbles homologues, Trib1, Trib2 and Trib3 are characterized by conserved motifs, including a pseudokinase domain and a C-terminal E3 ligase-binding domain.
Using Centromere Mediated Genome Elimination to Elucidate the Functional Redundancy of Candidate Telomere Binding Proteins in Arabidopsis thaliana.
Riha et al., Vienna, Austria. In Front Genet, 2014
Here we performed genetic analysis on the TRF-like family consisting of six proteins (TRB1, TRP1, TRFL1, TRFL2, TRFL4, and TRF9) which have previously shown to bind telomeric DNA in vitro.
Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages.
Akira et al., Suita, Japan. In Nature, 2013
Trib1 is an adaptor protein involved in protein degradation by interacting with COP1 ubiquitin ligase.
The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases.
Trischitta et al., Italy. In Endocr Rev, 2012
Tribbles homolog 3 (TRIB3) is a 45-kDa pseudokinase binding to and inhibiting Akt, a key mediator of insulin signaling.
The tribbles gene family and lipoprotein metabolism.
Kiss-Toth et al., Sheffield, United Kingdom. In Curr Opin Lipidol, 2012
Studies indicate tribbles 1 and tribbles 3 as regulators of lipid level and disease susceptibility genes in metabolic syndrome and type 2 diabetes.
Finding genes and variants for lipid levels after genome-wide association analysis.
Mohlke et al., Ann Arbor, United States. In Curr Opin Lipidol, 2012
Studies indicate that three loci for lipid levels identified by GWAS has identified functional genes GALNT2, TRIB1, and SORT1, and a functional variant at SORT1.
Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia.
Nakamura et al., Tokyo, Japan. In Blood, 2012
TRIB1 R107L gain-of-function mutation is associated with acute megakaryocytic leukemia.
Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39.
Smit et al., Wageningen, Netherlands. In J Agric Food Chem, 2011
TAS2R14 and TAS2R39 were activated by isoflavones and other isoflavonoids.
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Kooner et al., London, United Kingdom. In Nat Genet, 2011
We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827).
Association of the TRIB1 tribbles homolog 1 gene rs17321515 A>G polymorphism and serum lipid levels in the Mulao and Han populations.
Yang et al., Nanning, China. In Lipids Health Dis, 2010
The associations of TRIB1 rs17321515 SNP and serum lipid levels are different between the Mulao and Han populations.
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
Abecasis et al., Ann Arbor, United States. In Nat Genet, 2008
Overall, we identify strongly associated variants in eleven loci previously implicated in lipid metabolism (ABCA1, the APOA5-APOA4-APOC3-APOA1 and APOE-APOC clusters, APOB, CETP, GCKR, LDLR, LPL, LIPC, LIPG and PCSK9) and also in several newly identified loci (near MVK-MMAB and GALNT2, with variants primarily associated with high-density lipoprotein (HDL) cholesterol; near SORT1, with variants primarily associated with low-density lipoprotein (LDL) cholesterol; near TRIB1, MLXIPL and ANGPTL3, with variants primarily associated with triglycerides; and a locus encompassing several genes near NCAN, with variants strongly associated with both triglycerides and LDL cholesterol).
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
Orho-Melander et al., Boston, United States. In Nat Genet, 2008
Of the six newly identified chromosomal regions, two were associated with LDL cholesterol (1p13 near CELSR2, PSRC1 and SORT1 and 19p13 near CILP2 and PBX4), one with HDL cholesterol (1q42 in GALNT2) and five with triglycerides (7q11 near TBL2 and MLXIPL, 8q24 near TRIB1, 1q42 in GALNT2, 19p13 near CILP2 and PBX4 and 1p31 near ANGPTL3).
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