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Ubiquitin specific peptidase 47

TRFP, USP47, hTRFP
MED20 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al., 2003 [PubMed 14576168]).[supplied by OMIM, Aug 2009] (from NCBI)
Top mentioned proteins: Ubiquitin, POLYMERASE, CAN, V1a, fibrillin-1
Papers on TRFP
Expression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47.
New
Kakeya et al., Kyoto, Japan. In J Biochem, Dec 2015
Recombinant human USP47 was expressed in a baculovirus expression system and purified to homogeneity.
Deubiquitinase USP47/UBP64E Regulates β-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling.
New
Liu et al., Lexington, United States. In Mol Cell Biol, Oct 2015
In this study, by screening RNA interference (RNAi) libraries, we identified USP47 as a deubiquitinase that prevents β-catenin ubiquitination.
MicroRNA-204-5p inhibits gastric cancer cell proliferation by downregulating USP47 and RAB22A.
Huang et al., Wuxi, China. In Med Oncol, 2015
Subsequent mechanistic investigations identified that USP47 and RAB22A are direct functional targets of miR-204-5p in GC.
Minus end-directed motor KIFC3 suppresses E-cadherin degradation by recruiting USP47 to adherens junctions.
Takeichi et al., Kōbe, Japan. In Mol Biol Cell, 2015
Here we find that KIFC3 binds the ubiquitin-specific protease USP47, a protease that removes ubiquitin chains from substrates and hence inhibits proteasome-mediated proteolysis, and recruits it to AJs.
Monitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay.
Review
Parsons et al., Liverpool, United Kingdom. In Front Genet, 2013
For example, we have shown that the E3 ubiquitin ligase Mule, the tumor suppressor protein ARF, and the deubiquitylation enzyme USP47 modulate DNA repair by controlling cellular levels of DNA polymerase β, and also that polynucleotide kinase phosphatase levels are controlled by ATM-dependant phosphorylation and Cul4A-DDB1-STRAP-dependent ubiquitylation.
Regulation of ubiquitin and 26S proteasome mediated by phenolic compounds during oxidative stress.
Hong et al., Tainan City, Taiwan. In J Nutr Biochem, 2013
Phenolic compounds not only inhibited the 26S activity but also decreased the USP47 levels, which reduce the DNA damage repair rate during oxidative stress; in addition, the presence of DNA fragments, procaspase-3 and a decreased poly (ADP-ribose) polymerase also appeared as a result of the above conditions.
USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate katanin-p60-mediated axonal growth.
Chung et al., Seoul, South Korea. In J Neurosci, 2013
Here we showed that USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate the stability of katanin-p60 and thereby axonal growth.
Knockdown of specific host factors protects against influenza virus-induced cell death.
Coombs et al., Winnipeg, Canada. In Cell Death Dis, 2012
Three gene products, TNFSF13 (APRIL), TNFSF12-TNFSF13 (TWE-PRIL) and USP47, were selected because of the high levels of protection conferred by their silencing.
Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47.
Nicholson et al., United States. In Acs Med Chem Lett, 2012
Inhibitors of the cancer-related cysteine isopeptidase human ubiquitin-specific proteases 7 (USP7) and 47 (USP47) are considered to have potential as cancer therapeutics, owing to their ability to stabilize the tumor suppressor p53 and to decrease DNA polymerase β (Polβ), both of which are potential anticancer effects.
USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β.
GeneRIF
Dianov et al., Oxford, United Kingdom. In Mol Cell, 2011
USP47 has a role in regulating DNA repair and maintaining genome integrity
The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival.
GeneRIF
Melino et al., Roma, Italy. In Oncogene, 2010
USP47, a novel beta-Trcp interactor, regulates cell growth and survival, potentially providing a novel target for anticancer therapies.
Deubiquitinase activities required for hepatocyte growth factor-induced scattering of epithelial cells.
Clague et al., Liverpool, United Kingdom. In Curr Biol, 2009
Different phenotypes are evident that range from full loss of scattering, similar to receptor knockdown (e.g., USP30, USP33, USP47), to loss of cell-cell contacts even in the absence of HGF but defective motility (e.g., USP3, ATXN3L).
Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort.
Pharoah et al., Cambridge, United Kingdom. In Breast Cancer Res, 2007
This SNP is part of a large linkage disequilibrium block, which contains CCND3, BYSL, TRFP, USP49, C6ofr49, FRS3, and PGC.
A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.
Conaway et al., Kansas City, United States. In J Biol Chem, 2004
In addition, we show that hIntersex assembles into a subcomplex with Mediator subunits p28b and TRFP.
The human homologue of Drosophila TRF-proximal protein is associated with an RNA polymerase II-SRB complex.
Roeder et al., New York City, United States. In J Biol Chem, 1999
On the basis of its copurification with an SRB-containing RNA polymerase II complex by conventional chromatography procedures, we have identified a human homologue of Drosophila TRF-proximal protein, designated hTRFP, and isolated its cognate cDNA.
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