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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 Nov 2016.

Telomeric repeat binding factor 2

TRF2, Stud, Telomeric Repeat Binding Protein 2, TLF
This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TRF1, CAN, Thymopentin, Rap1, Atm
Papers using TRF2 antibodies
Arginine methylation regulates telomere length and stability
Supplier
Loayza Diego et al., In Aging (Albany NY), 2008
... published fusions with the GAL4 activation domain: TRF1-GAD, TRF2-GAD, and POT1¬GAD, all cloned into the pACT2 vector (Clontech).
Papers on TRF2
TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres.
New
de Lange et al., New York City, United States. In Mol Cell, Feb 2016
Similarly, telomeres lacking TRF2 undergo ATM-controlled CtIP-dependent hyper-resection when the repression by 53BP1/Rif1 is alleviated.
A higher-order entity formed by the flexible assembly of RAP1 with TRF2.
New
Le Du et al., Gif-sur-Yvette, France. In Nucleic Acids Res, Feb 2016
Within shelterin, RAP1 is recruited through its interaction with TRF2, and TRF2 is required for telomere protection through a network of nucleic acid and protein interactions.
TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection.
New
Giraud-Panis et al., Nice, France. In Mol Cell, Feb 2016
We show here that a dimer of the shelterin subunit TRF2 wraps ∼90 bp of DNA through several lysine and arginine residues localized around its homodimerization domain.
Lamina Associated Polypeptide 1 (LAP1) Interactome and Its Functional Features.
New
Rebelo et al., Aveiro, Portugal. In Membranes (basel), Dec 2015
Several functionally relevant proteins, such as TRF2, TERF2IP, RIF1, ATM, MAD2L1 and MAD2L1BP were identified and these support the putative functions proposed for LAP1.
Interfacial Reaction Characteristics of Au Stud/Sn/Cu Pillar Bump During Annealing and Current Stressing.
New
Park et al., In J Nanosci Nanotechnol, Nov 2015
In this work, intermetallic compound (IMC) growth behavior in Au stud/Sn/Cu pillar bumps was investigated under annealing and current stressing conditions.
Molecular mechanisms of activity and derepression of alternative lengthening of telomeres.
Review
New
Reddel et al., Sydney, Australia. In Nat Struct Mol Biol, Nov 2015
This multistep process is facilitated by loss of the ATRX or DAXX chromatin-remodeling factors and by abnormalities of the telomere nucleoprotein architecture, including altered DNA sequence and decreased TRF2 saturation.
The ERCC1 and ERCC4 (XPF) genes and gene products.
Review
New
Wood et al., United States. In Gene, Oct 2015
ERCC1-XPF interacts with other proteins including XPA, RPA, SLX4 and TRF2 to perform its functions.
Cell death during crisis is mediated by mitotic telomere deprotection.
New
Impact
Karlseder et al., Los Angeles, United States. In Nature, Jul 2015
Exacerbation of mitotic telomere deprotection by partial TRF2 (also known as TERF2) knockdown increased the ratio of cells that died during mitotic arrest and sensitized cancer cells to mitotic poisons.
No DDRama at chromosome ends: TRF2 takes centre stage.
Review
New
Porro et al., Lausanne, Switzerland. In Trends Biochem Sci, May 2015
Within this complex, TRF2 has emerged as the key player, dictating different states of telomere protection during the replicative lifespan of a cell.
Antimicrobial Peptides in Human Sepsis.
Review
Schuerholz et al., Aachen, Germany. In Front Immunol, 2014
The recombinant form of lactoferrin [talactoferrin alpha (TLF)] has been shown to decrease mortality in critically ill patients.
Shelterin proteins and cancer.
Review
Trivedi et al., Vellore, India. In Asian Pac J Cancer Prev, 2014
It comprises six proteins, namely TRF1, TRF2, TIN2, POT1, TPP1 and RAP1.
Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.
Impact
Zhuang et al., New York City, United States. In Cell, 2013
Conditional deletion of individual components of shelterin showed that TRF2 was required for the formation and/or maintenance of t-loops, whereas deletion of TRF1, Rap1, or the POT1 proteins (POT1a and POT1b) had no effect on the frequency of t-loop occurrence.
Mechanism of Trypanosoma brucei gambiense resistance to human serum.
Impact
Pays et al., Brussels, Belgium. In Nature, 2013
Human immunity to some African trypanosomes is due to two serum complexes designated trypanolytic factors (TLF-1 and -2), which both contain haptoglobin-related protein (HPR) and apolipoprotein LI (APOL1).
TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells.
Impact
Gilson et al., Lyon, France. In Nat Cell Biol, 2013
Increased levels of TRF2, a key factor in telomere protection, are observed in various human malignancies and contribute to oncogenesis.
A two-step mechanism for TRF2-mediated chromosome-end protection.
Impact
Denchi et al., Los Angeles, United States. In Nature, 2013
Within this complex, TRF2 (also known as TERF2) has a crucial role in end protection through the suppression of ATM activation and the formation of end-to-end chromosome fusions.
TATA-binding protein (TBP)-like protein is required for p53-dependent transcriptional activation of upstream promoter of p21Waf1/Cip1 gene.
GeneRIF
Tamura et al., Chiba, Japan. In J Biol Chem, 2012
TLP mediates p53-governed transcriptional activation of the p21 upstream promoter.
TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner.
GeneRIF
Gilson et al., Roma, Italy. In Plos One, 2011
TRF2 negatively regulates the number of nucleosomes at human telomeres by a cell cycle-dependent mechanism that alters internucleosomal distance.
Mutant telomerase RNAs induce DNA damage and apoptosis via the TRF2-ATM pathway in telomerase-overexpressing primary fibroblasts.
GeneRIF
Wang et al., Singapore, Singapore. In Febs J, 2011
Data show that mutant template human telomerase RNAs (MT-hTers) induce DNA damage after phosphorylation of ATM and p53 via suppression of TRF2, which may eventually lead to apoptosis via elevation of GADD45gamma.
The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats.
GeneRIF
Gilson et al., Lyon, France. In Cell Res, 2011
A subset of TRF1 and TRF2 binding sites correspond to nontelomeric satellite DNA repeats.
Human telomeric proteins occupy selective interstitial sites.
GeneRIF
Songyang et al., Houston, United States. In Cell Res, 2011
Study investigated the binding sites of telomeric proteins along human chromosomes; RAP1 and TRF2 could be found on a small number of interstitial sites, including regions that are proximal to genes.
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