Emerging potassium channel targets for the treatment of pain.
London, United Kingdom. In Curr Opin Support Palliat Care, Jun 2015
Genetic analyses illustrate that K+ channel gene variation can predict pain sensitivity (KCNS1, GIRKs), risk for persistent pain (KCNS1, GIRKs, TRESK) and analgesic effectiveness (GIRK2).
Migraine genetics: Part II.
Philadelphia, United States. In Headache, 2013
TWIK-related spinal cord potassium channel is involved in migraine by screening the KCNK18 gene in subjects diagnosed with migraine.
TRESK: the lone ranger of two-pore domain potassium channels.
Budapest, Hungary. In Mol Cell Endocrinol, 2012
dominant-negative mutation of human TRESK was found to be linked to migraine with aura in a large pedigree. It is hoped that future TRESK agonists may prevent or ameliorate the debilitating symptoms of migraine.
Molecular background of leak K+ currents: two-pore domain potassium channels.
Budapest, Hungary. In Physiol Rev, 2010
Basic physicochemical parameters (e.g., pH, temperature, membrane stretch) and also several intracellular signaling pathways substantially and specifically modulate the different members of the six K(2P) channel subfamilies (TWIK, TREK, TASK, TALK, THIK, and TRESK).