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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Triggering receptor expressed on myeloid cells-like 2

TREML2, TLT-2, Trem-like transcript 2
TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008] (from NCBI)
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Top mentioned proteins: B7-H3, TREM2, AGE, TREM-1, Interleukin-2
Papers on TREML2
[Research Progress on Co-stimulating Molecule B7-H3 in Hematological Malignancies].
Review
New
Ke et al., Beijing, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, Dec 2015
The triggering receptor expressed on myeloid cell (TREM)-like transcript 2 (TLT-2) is a possible receptor for B7-H3, but it is not confirmed.
CFH Variants Affect Structural and Functional Brain Changes and Genetic Risk of Alzheimer's Disease.
New
Yao et al., Kunming, China. In Neuropsychopharmacology, Sep 2015
Our results showed that the AD-associated top immune genes reported in Europeans (CR1, CD33, CLU, and TREML2) have weak effects in Chinese, whereas CFH showed strong effects.
Expression levels of B7-H3 and TLT-2 in human oral squamous cell carcinoma.
New
Yang et al., Shenzhen, China. In Oncol Lett, Aug 2015
UNASSIGNED: The aim of the present study was to investigate the role of immune regulatory molecules B7-H3 [also known as cluster of differentiation 276] and triggering receptor expressed on myeloid cell-like transcript-2 (TLT-2) in patients with oral squamous cell carcinoma (OSCC).
A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology.
New
De Jager et al., Boston, United States. In Ann Neurol, Mar 2015
OBJECTIVE: Genome-wide association studies have linked variants in TREM2 (triggering receptor expressed on myeloid cells 2) and TREML2 with Alzheimer disease (AD) and AD endophenotypes.
Triggering receptor expressed on myeloid cells receptor family modulators: a patent review.
Review
Agrawal et al., Omaha, United States. In Expert Opin Ther Pat, 2014
New roles for TREM-1, TREM-2, TLT-1 and TLT-2 in maladies ranging from acute and chronic inflammatory disorders to cardiovascular diseases and cancers are discussed.
Missense variant in TREML2 protects against Alzheimer's disease.
Cruchaga et al., Saint Louis, United States. In Neurobiol Aging, 2014
In addition, common single nucleotide polymorphisms in this genomic region are associated with cerebrospinal fluid biomarkers for AD and a common intergenic variant found near the TREML2 gene has been identified to be protective for AD.
Male-specific genetic effect on hypertension and metabolic disorders.
Park et al., Ch'unch'ŏn, South Korea. In Hum Genet, 2014
Five gene variants, rs11066280 (C12orf51), rs12229654 and rs3782889 (MYL2), rs2072134 (OAS3), rs2093395 (TREML2), and rs17249754 (ATP2B1), were found to be associated with hypertension mostly in men (P = 4.76 × 10(-14) to 4.46 × 10(-7) in the joint analysis); three SNPs (rs11066280, rs12229654, and rs3782889) remained significant after Bonferroni correction in an independent population.
Integrative analysis of multiple diverse omics datasets by sparse group multitask regression.
Wang et al., New Orleans, United States. In Front Cell Dev Biol, 2013
Several other genes such as TREML2, HTR1E, and GLO1 are shown to be novel susceptible genes for osteoporosis, as confirmed from other studies.
Murine b7-h3 is a co-stimulatory molecule for T cell activation.
Feng et al., Suzhou, China. In Monoclon Antib Immunodiagn Immunother, 2013
Our study suggested that there was no interaction of murine B7-H3 with a triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2).
Generation and characterization of two novel monoclonal antibodies produced against human TLT-2 molecule.
Zhang et al., Suzhou, China. In Monoclon Antib Immunodiagn Immunother, 2013
Trem-like transcript 2 (TLT-2), one of the TREM family members, which is expressed on B cells, T cells, and macrophages, plays a critical role in immune response mechanism.
Identification of TLT2 as an engulfment receptor for apoptotic cells.
GeneRIF
Liu et al., Birmingham, United States. In J Immunol, 2012
Thus, our studies identified TLT2 as an engulfment receptor for apoptotic cells.
TLT2 potentiates neutrophil antibacterial activity and chemotaxis in response to G protein-coupled receptor-mediated signaling.
GeneRIF
Justement et al., Birmingham, United States. In J Immunol, 2011
TLT2 ligation enhances the neutrophil response to the formylated peptide FMLF, leading to increased reactive oxygen species production, degranulation, and chemotaxis
Enhancement of effector CD8+ T-cell function by tumour-associated B7-H3 and modulation of its counter-receptor triggering receptor expressed on myeloid cell-like transcript 2 at tumour sites.
GeneRIF
Azuma et al., Tokyo, Japan. In Immunology, 2010
(+) T-cell effector function, possibly by ligation of TLT-2 on tumour-infiltrating CD8(+) T cells at the local tumour site.
B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction.
GeneRIF
Steinberger et al., Vienna, Austria. In Eur J Immunol, 2009
Data do not point to a role for TREML2 as a receptor for B7-H3.
Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses.
GeneRIF
Azuma et al., Tokyo, Japan. In Proc Natl Acad Sci U S A, 2008
analysis of an interaction between B7-H3 and TLT-2 that preferentially enhances CD8(+) T cell activation
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