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Triggering receptor expressed on myeloid cells 2

TREM2, triggering receptor expressed on myeloid cells-2
The protein encoded by this gene is a membrane protein that forms a receptor signaling complex with TYROBP. The encoded protein may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DAP12, CAN, AGE, HAD, apolipoprotein E
Papers on TREM2
Perturbation of the transcriptome: implications of the innate immune system in Alzheimer's disease.
Review
New
Lei et al., Beijing, China. In Curr Opin Pharmacol, Feb 2016
The combination of transcriptome studies and other types of studies has further elucidated the roles of specific immune pathways in distinct cell types during AD development and highlighted the critical contributions from immune genes such as TREM2.
TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice.
New
Yu et al., Nanjing, China. In Mol Neurobiol, Feb 2016
UNASSIGNED: Previously, we showed that overexpression of triggering receptor expressed on myeloid cells 2 (TREM2), a microglia-specific immune receptor, in the brain of a middle-aged (7 months old) APPswe/PS1dE9 mice could ameliorate Alzheimer's disease (AD)-related neuropathology by enhancement of microglial amyloid-β (Aβ) phagocytosis.
Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status.
New
Cruchaga et al., Saint Louis, United States. In Acta Neuropathol, Feb 2016
UNASSIGNED: Low frequency coding variants in TREM2 are associated with increased Alzheimer disease (AD) risk, while loss of functions mutations in the gene lead to an autosomal recessive early-onset dementia, named Nasu-Hakola disease (NHD).
Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone.
New
Zetterberg et al., Göteborg, Sweden. In Mult Scler, Feb 2016
BACKGROUND: Microglia-mediated proteolysis of the triggering receptor expressed on myeloid cells-2 (TREM-2) produces soluble TREM-2 (sTREM-2) that can be measured in cerebrospinal fluid (CSF) samples.
Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases.
Review
New
Buckner et al., Seattle, United States. In Immunol Rev, Jan 2016
This suggests that Lyp serves to downregulate a TLR inhibitory pathway in monocytes, and we propose that Lyp inhibits the TREM2/DAP12 inhibitory pathway.
The immunobiology of Campylobacter jejuni: Innate immunity and autoimmune diseases.
Review
New
Phongsisay, Fukuoka, Japan. In Immunobiology, Jan 2016
Furthermore, C. jejuni targets MyD88, NLRP3 inflammasome, TIR-domain-containing adapter-inducing interferon-β (TRIF), sialic acid-binding immunoglobulin-like lectins (Siglecs), macrophage galactose-type lectin (MGL), and immunoglobulin-like receptors (TREM2, LMIR5/CD300b).
Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease.
New
Zetterberg et al., Göteborg, Sweden. In Mol Neurodegener, Dec 2015
BACKGROUND: The discovery that heterozygous missense mutations in the gene encoding triggering receptor expressed on myeloid cells 2 (TREM2) are risk factors for Alzheimer's disease (AD), with only the apolipoprotein E (APOE) ε4 gene allele conferring a higher risk, has led to increased interest in immune biology in the brain.
Association study of TREM2 polymorphism rs75932628 with leucoaraiosis or Parkinson's disease in the Han Chinese population.
New
Tzeng et al., Xiamen, China. In Bmj Open, Dec 2015
OBJECTIVES: The previously reported functional mutation rs75932628-T (p.R47H) in the triggering receptor expressed on myeloid cells 2 (TREM2) is a genetic risk factor for Alzheimer's disease, Parkinson's disease (PD) and frontotemporal dementia, in European populations.
Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease.
Review
New
Pocock et al., London, United Kingdom. In Curr Opin Neurobiol, Nov 2015
Furthermore, recent identification of a low frequency mutation in the gene encoding the triggering receptor expressed in myeloid cells 2 protein (TREM2) confers increased risk of AD in LOAD cohorts with an effect size similar to that for APOE, until recently the only identified genetic risk factor associated with LOAD [9,10(••)] (Figure 1).
TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.
New
Impact
Colonna et al., Saint Louis, United States. In Cell, Apr 2015
Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface receptor that triggers intracellular protein tyrosine phosphorylation.
Misframed ubiquitin and impaired protein quality control: an early event in Alzheimer's disease.
Review
van Leeuwen et al., Maastricht, Netherlands. In Front Mol Neurosci, 2014
Other medium-risk factors such as triggering receptor expressed on myeloid cells 2 (TREM2) and nine low risk factors from Genome Wide Association Studies (GWAS) were associated with AD.
Variant of TREM2 associated with the risk of Alzheimer's disease.
Impact
Stefansson et al., Reykjavík, Iceland. In N Engl J Med, 2013
RESULTS: A rare missense mutation (rs75932628-T) in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2), which was predicted to result in an R47H substitution, was found to confer a significant risk of Alzheimer's disease in Iceland (odds ratio, 2.92; 95% confidence interval [CI], 2.09 to 4.09; P=3.42×10(-10)).
TREM2 variants in Alzheimer's disease.
Impact
Alzheimer Genetic Analysis Group et al., London, United Kingdom. In N Engl J Med, 2013
BACKGROUND: Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor expressed on myeloid cells 2 protein, have previously been associated with an autosomal recessive form of early-onset dementia.
TLT-1s, alternative transcripts of triggering receptor expressed on myeloid cell-like transcript-1 (TLT-1), Inhibits the triggering receptor expressed on myeloid cell-2 (TREM-2)-mediated signaling pathway during osteoclastogenesis.
GeneRIF
Kim et al., Seoul, South Korea. In J Biol Chem, 2012
TLT-1s, alternative transcripts of triggering receptor expressed on myeloid cell-like transcript-1 (TLT-1), Inhibits the triggering receptor expressed on myeloid cell-2 (TREM-2)-mediated signaling pathway during osteoclastogenesis.
TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis.
GeneRIF
Colonna et al., Saint Louis, United States. In J Immunol, 2012
TREM2 regulates the rate of osteoclastogenesis
TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells.
GeneRIF
Hamerman et al., Seattle, United States. In Eur J Immunol, 2012
TREM-2 receptor transduces inhibitory signals due to recognition of an endogenous ligand.
Nasu-Hakola disease with a splicing mutation of TREM2 in a Japanese family.
GeneRIF
Satoh et al., Toride, Japan. In Eur J Neurol, 2011
This is the first report of a Japanese Nasu-Hakola disease family caused by a splicing mutation of TREM2 that induces both neuroinflammation and neurodegeneration.
Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease.
GeneRIF
Carson et al., Riverside, United States. In Asn Neuro, 2009
TREM2 expression correlates positively with amyloid phagocytosis in a transgenic model of amyloid pathology.
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.
Impact
Kikutani et al., Suita, Japan. In Nat Cell Biol, 2006
Furthermore, we show that plexin-A1 associates with the triggering receptor expressed on myeloid cells-2 (Trem-2), linking semaphorin-signalling to the immuno-receptor tyrosine-based activation motif (ITAM)-bearing adaptor protein, DAP12.
TREMs in the immune system and beyond.
Review
Impact
Colonna, Saint Louis, United States. In Nat Rev Immunol, 2003
TREM1 and TREM2 activate myeloid cells by signalling through the adaptor protein DAP12.
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