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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Triggering receptor expressed on myeloid cells 1

TREM-1, triggering receptor expressed on myeloid cells-1
This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: CAN, HAD, Interleukin-6, IL-8, C-reactive protein
Papers on TREM-1
TREM-like transcript 2 is stored in human neutrophil primary granules and is up-regulated in response to inflammatory mediators.
New
Justement et al., Los Angeles, United States. In J Leukoc Biol, Feb 2016
Of the 4 conserved members, including triggering receptor expressed on myeloid cells 1 and 2 and triggering receptor expressed on myeloid cell-like transcripts 1 and 2, relatively little is known about triggering receptor expressed on myeloid cell-like transcript 2 expression and function, particularly in humans.
Novel Attributions of TREMs in Immunity.
New
Zhang et al., Wuhan, China. In Curr Issues Mol Biol, Feb 2016
The well established interaction of TREM-1 with microbial products like LPS and the emerging interactions with products from different important diseases of brain, heart, lungs and skin demands its full investigation as a therapeutic target.
[Correlation of triggering receptors expressed on myeloid cells-1 with the oncogenesis and progression of hepatocellular carcinoma].
New
Yang et al., Bengbu, China. In Nan Fang Yi Ke Da Xue Xue Bao, Jan 2016
OBJECTIVE: To investigate the role of triggering receptors expressed on myeloid cells-1 (TREM-1) in the oncogenesis and progression of hepatocellular carcinoma (HCC).
TREM-1 accentuated lung injury via miR-155 is inhibited by LP17 nanomedicine.
New
Sadikot et al., Chicago, United States. In Am J Physiol Lung Cell Mol Physiol, Jan 2016
UNASSIGNED: TREM-1 is a superimmunoglobulin receptor expressed on myeloid cells.
TGF-β1 Upregulates the Expression of Triggering Receptor Expressed on Myeloid Cells 1 in Murine Lungs.
New
Guan et al., Changsha, China. In Sci Rep, Dec 2015
Triggering receptor expressed on myeloid cells 1 (TREM-1) increases the expression of TGF-β family genes, which are known as profibrogenic cytokines in the pathogenesis of pulmonary fibrosis.
GPR84 and TREM-1 signaling contribute to the pathogenesis of reflux esophagitis.
New
Ulrich-Merzenich et al., Münster, Germany. In Mol Med, Dec 2015
Most regulated cyto-/chemokines are linked to the TREM-1 signaling pathway.
The Triggering Receptor Expressed on Myeloid cells-1: A new player during acute myocardial infarction.
Review
New
Sébastien et al., Nancy, France. In Pharmacol Res, Oct 2015
The triggering receptor expressed on myeloid cells-1 (TREM-1) is a highly conserved immune-receptor expressed by neutrophils and monocytes that acts as an amplifier of the innate immune response.
Targeting TREM-1 Signaling in the Presence of Antibiotics is Effective Against Streptococcal Toxic-Shock-Like Syndrome (STSLS) Caused by Streptococcus suis.
Zhang et al., Wuhan, China. In Front Cell Infect Microbiol, 2014
Our previous study indicated that highly virulent S. suis infection could activate the TREM-1 signaling pathway, which promotes host clearance of S. suis during early infection.
Triggering receptor expressed on myeloid cells receptor family modulators: a patent review.
Review
Agrawal et al., Omaha, United States. In Expert Opin Ther Pat, 2014
TREM-1 (CD354) and TREM-2 share the transmembrane adaptor DNAX-activation protein of 12 kDa (DAP12), but they possess separate stimulatory and inhibitory functional roles, especially in myeloid cells.
The Role of HMGB1 Signaling Pathway in the Development and Progression of Hepatocellular Carcinoma: A Review.
Review
Cao et al., Shiyan, China. In Int J Mol Sci, 2014
HMGB1 and its downstream receptors RAGE, TLRs and TREM-1 may be potential anticancer targets.
Triggering receptor expressed on myeloid cells-1 (TREM-1): a new player in antiviral immunity?
Review
Verma et al., Honolulu, United States. In Front Microbiol, 2013
Although the ligand(s) for TREM have not yet been fully identified, circumstantial evidence indicates that danger- and pathogen-associated molecular patterns (DAMPs and PAMPs) can induce cytokine production via TREM-1 activation.
The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis.
Review
Danese et al., Rozzano, Italy. In J Transl Med, 2013
TREM-1 and TREM-2, the best-characterized receptors so far, play divergent roles in several infectious diseases.
Expression of TREM-1 in hepatic stellate cells and prognostic value in hepatitis B-related hepatocellular carcinoma.
GeneRIF
Fan et al., Shanghai, China. In Cancer Sci, 2012
levels of sTREM-1 were significantly higher in patients with epatocellular carcinoma (HCC) than those with benign liver tumors; peritumoral density of TREM-1 was shown to be an independent prognosis predictor; observations suggest that TREM-1 is related to the aggressive tumor behavior and has potential value as a prognostic factor for HCC
Role of MMPs in orchestrating inflammatory response in human monocytes via a TREM-1-PI3K-NF-κB pathway.
GeneRIF
López-Collazo et al., Madrid, Spain. In J Leukoc Biol, 2012
the sustained TREM-1 expression at the cell surface suffices to block the progress of a refractory state in human monocytes
TREM-1 is a positive regulator of TNF-α and IL-8 production in U937 foam cells.
GeneRIF
Zhao et al., Changchun, China. In Bosn J Basic Med Sci, 2012
Our finding that TREM-1 controls the production of interleukin-8 and TNF-alpha in U937 foam cells defines a potentially critical role of TREM-1 in the pathogenesis of atherosclerosis
Increased sTREM-1 in pregnant women with premature rupture of membranes and subclinical chorioamnionitis.
GeneRIF
Xiao et al., Wenzhou, China. In Mol Med Report, 2012
Serum and amniotic fluid sTREM-1 levels may emerge as early biological indicators for predicting PROM complicated with subclinical chorioamnionitis.
Blocking TREM-1 signaling prolongs survival of mice with Pseudomonas aeruginosa induced sepsis.
GeneRIF
Sun et al., Wuhan, China. In Cell Immunol, 2011
TREM-1 was not expressed on lymphocytes but emerged on the cell surface of neutrophils and peritoneal macrophages.
The TREM receptor family and signal integration.
Review
Impact
Colonna et al., Saint Louis, United States. In Nat Immunol, 2006
TREM-1, the first to be identified, acts to amplify inflammation.
Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia.
Impact
Bollaert et al., Nancy, France. In N Engl J Med, 2004
The triggering receptor expressed on myeloid cells (TREM-1) is a member of the immunoglobulin superfamily, and its expression on phagocytes is specifically up-regulated by microbial products.
TREM-1 amplifies inflammation and is a crucial mediator of septic shock.
Impact
Colonna et al., Basel, Switzerland. In Nature, 2001
TREM-1 is an activating receptor expressed at high levels on neutrophils and monocytes that infiltrate human tissues infected with bacteria.
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