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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Potassium channel, subfamily K, member 10

tandem-pore K(+) channel that is a mechanosensitive and fatty acid-stimulated K(+) channel [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: TREK-1, TRAAK, ACID, K2P, TASK-3
Papers on TREK-2
The isoforms generated by alternative translation initiation adopt similar conformation in the selectivity filter in TREK-2.
Ma et al., Beijing, China. In J Physiol Biochem, Dec 2015
TREK-2 (TWIK-related K(+) channel-2), a member of two-pore domain potassium (K2P) channel family, tunes cellular excitability via conducting leak or background currents.
Role of leak potassium channels in pain signaling.
Toyoda et al., China. In Brain Res Bull, Oct 2015
In this review, we describe evidence for the roles of TASK1, TASK3, TREK1, TREK2, TRAAK and TRESK channels in pain signaling and behavior.
How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.
Brohawn, New York City, United States. In Ann N Y Acad Sci, Sep 2015
Here, I review the current understanding of force gating for a family of metazoan mechanosensitive ion channels, the two-pore domain K(+) channels (K2Ps) TRAAK, TREK1, and TREK2.
Insights into the stimulatory mechanism of 2-aminoethoxydiphenyl borate on TREK-2 potassium channel.
Ma et al., Guangzhou, China. In Neuroscience, Sep 2015
TREK-2 displays much higher sensitivity to 2-APB compared with TREK-1, despite that these two channels share the highest homology among K2P members.
Muscarinic modulation of TREK currents in mouse sympathetic superior cervical ganglion neurons.
Reboreda et al., Vigo, Spain. In Eur J Neurosci, Jul 2015
Here, we report the presence of a riluzole-activated current (IRIL ) that flows through the TREK-2 channels, and that is also inhibited by muscarinic agonists in neurons of the mouse superior cervical ganglion (mSCG).
Two-pore domain potassium channels: potential therapeutic targets for the treatment of pain.
Veale et al., Chatham, United Kingdom. In Pflugers Arch, May 2015
Expression of several different K2P channel subunits has been detected in nociceptive dorsal root ganglion neurons and trigeminal ganglion neurons, in particular, TREK1, TREK2, TRESK, TRAAK, TASK3 and TWIK1 channels.
Differential sensitivity of TREK-1, TREK-2 and TRAAK background potassium channels to the polycationic dye ruthenium red.
Czirják et al., Budapest, Hungary. In Br J Pharmacol, Apr 2015
TREK-2 (K2 P 10.1) proved to be highly sensitive to RR (IC50 = 0.2 μM), whereas TREK-1 (K2 P 2.1) was not affected by the compound.
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Carpenter et al., Oxford, United Kingdom. In Science, Apr 2015
TREK-2 (KCNK10/K2P10), a two-pore domain potassium (K2P) channel, is gated by multiple stimuli such as stretch, fatty acids, and pH and by several drugs.
Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation.
Thomas et al., Heidelberg, Germany. In Br J Pharmacol, 2014
K2P 2.1 (TREK1) and K2P 10.1 (TREK2) channels are expressed in the heart and regulated by alternative translation initiation (ATI) of their mRNA, producing functionally distinct channel variants.
Cold hypersensitivity increases with age in mice with sickle cell disease.
Stucky et al., Milwaukee, United States. In Pain, 2014
These included the transient receptor potential melastatin 8 (Trpm8) and transient receptor potential ankyrin 1 (Trpa1) channels, as well as the 2-pore domain potassium channels, TREK-1 (Kcnk2), TREK-2 (Kcnk10), and TRAAK (Kcnk4).
Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2 channels in astrocytes after transient cerebral ischemia.
Eaton et al., Bayamón, Puerto Rico. In Plos One, 2014
We have previously shown that TREK-2 potassium channels in cultured astrocytes are up-regulated by ischemia and may support glutamate clearance by astrocytes during ischemia.
Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception.
Noël et al., Clermont-Ferrand, France. In Pain, 2014
The TREK2 channel as well as the related TREK1 and TRAAK channels are mechanical-, thermal- and lipid-gated channels that share many regulatory properties.
Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.
Sandoz et al., Nice, France. In Proc Natl Acad Sci U S A, 2014
One family of lipid-regulated membrane proteins is the TWIK-related K channel (TREK) subfamily of K2P channels: TREK1, TREK2, and TWIK-related arachdonic acid stimulated K(+) channel (TRAAK).
Temperature sensitivity of two-pore (K2P) potassium channels.
Bagriantsev et al., New Haven, United States. In Curr Top Membr, 2013
TREK-2 (K2P10.1/KCNK10),
Identification and characterization of alternative splice variants of the mouse Trek2/Kcnk10 gene.
Wickman et al., Minneapolis, United States. In Neuroscience, 2011
Two novel splice isoforms of Trek2 are characterized, both showing prominent expression in the central nervous system and suggesting a potential role for Trek2 amino terminus in channel trafficking and/or stability.
Molecular regulations governing TREK and TRAAK channel functions.
Lesage et al., Nice, France. In Channels (austin), 2011
This review focuses on TREK-1, TREK-2 and TRAAK channels subfamily and on the mechanisms that contribute to their molecular heterogeneity and functional regulations.
Alternative splicing determines mRNA translation initiation and function of human K(2P)10.1 K+ channels.
Thomas et al., Heidelberg, Germany. In J Physiol, 2011
Tissue-specific mRNA splicing regulates alternative translation initiation (ATI) of human K(2P)10.1 K+ background channels via recombination of 5 nucleotide motifs.
Baicalein and wogonin are activators of rat TREK-2 two-pore domain K+ channel.
Han et al., Chinju, South Korea. In Acta Physiol (oxf), 2011
These results suggest that baicalein- and wogonin-induced TREK-2 activation help set the resting membrane potential of cells exposed to pathological conditions and thus may give beneficial effects in neuroprotection.
RNA interference-mediated knockdown of the mouse gene encoding potassium channel subfamily K member 10 inhibits hormone-induced differentiation of 3T3-L1 preadipocytes.
Kobayashi et al., Fukushima, Japan. In Comp Biochem Physiol B Biochem Mol Biol, 2010
KCNK10 plays an important role in the early stages of preadipocyte differentiation.
AMP-activated protein kinase inhibits TREK channels.
Mulkey et al., Mansfield City, United States. In J Physiol, 2010
TREK channels may represent the AMPK-inhibited background K(+) channels that mediate activation of glomus cells by hypoxia.
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