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Potassium channel, subfamily K, member 2

This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, TREK-2, TRAAK, K2P, CAN
Papers on TREK-1
Ischaemic concentrations of lactate increase TREK1 channel activity by interacting with a single histidine residue in the carboxy terminal domain.
Sikdar et al., Bengaluru, India. In J Physiol, Feb 2016
KEY POINTS: The physiological metabolite, lactate and the two-pore domain leak potassium channel, TREK1 are known neuroprotectants against cerebral ischaemia.
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Ducki et al., Clermont-Ferrand, France. In J Med Chem, Jan 2016
The TWIK-related K(+) channel (TREK-1) belongs to the two-pore domain K(+) channels (K2P) and displays various properties including sensitivity to physical (membrane stretch, acidosis, temperature) and chemical stimuli (signaling lipids, volatile anesthetics).
TREK1 channel blockade induces an antidepressant-like response synergizing with 5-HT1A receptor signaling.
Zhang et al., Nanjing, China. In Eur Neuropsychopharmacol, Dec 2015
Recently, the two-pore domain potassium channel TREK1 has been implicated in mood regulation and TREK-1 antagonists could be the promising antidepressant.
Role of leak potassium channels in pain signaling.
Toyoda et al., China. In Brain Res Bull, Oct 2015
In this review, we describe evidence for the roles of TASK1, TASK3, TREK1, TREK2, TRAAK and TRESK channels in pain signaling and behavior.
How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.
Brohawn, New York City, United States. In Ann N Y Acad Sci, Sep 2015
Here, I review the current understanding of force gating for a family of metazoan mechanosensitive ion channels, the two-pore domain K(+) channels (K2Ps) TRAAK, TREK1, and TREK2.
The CNS under pathophysiologic attack--examining the role of K₂p channels.
Bittner et al., Münster, Germany. In Pflugers Arch, May 2015
On the blood-brain barrier, TREK1 channels regulate immune cell trafficking under autoinflammatory conditions.
Two-pore domain potassium channels enable action potential generation in the absence of voltage-gated potassium channels.
Brickley et al., Boston, United States. In Pflugers Arch, May 2015
Recombinant expression of either TREK-1 or TASK-3 channels was then used to generate a hyperpolarised resting membrane potential (RMP) leading to the characteristic non-linear current-voltage relationship expected of a K2P-mediated conductance.
Pulmonary epithelial barrier function: some new players and mechanisms.
Sidhaye et al., Baltimore, United States. In Am J Physiol Lung Cell Mol Physiol, May 2015
In the next section, we will address transcellular ion transport and highlight the role of Trek-1 in epithelial responses to lung injury.
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Carpenter et al., Oxford, United Kingdom. In Science, Apr 2015
TREK-2 (KCNK10/K2P10), a two-pore domain potassium (K2P) channel, is gated by multiple stimuli such as stretch, fatty acids, and pH and by several drugs.
Effects of fluoxetine on protein expression of potassium ion channels in the brain of chronic mild stress rats.
Wang et al., Beijing, China. In Acta Pharm Sin B, 2015
The expression of TREK-1 channel was also obviously increased in frontal cortex in CMS rats.
Electrogenic transport and K(+) ion channel expression by the human endolymphatic sac epithelium.
Choi et al., Seoul, South Korea. In Sci Rep, 2014
The identified K(+) channels involved in the electrogenic transport were KCNN2, KCNJ14, KCNK2, and KCNK6, and the K(+) transports via those channels are thought to play an important role in the maintenance of the unique ionic milieu of the inner ear fluid.
Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS.
Meuth et al., Münster, Germany. In Nat Med, 2013
These beneficial effects were reduced in Kcnk2(-/-) mice, suggesting TREK-1 activating compounds may be used therapeutically to treat diseases related to BBB dysfunction.
TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation.
Lee et al., Seoul, South Korea. In Cell, 2012
The fast mode requires activation of G(αi), dissociation of G(βγ), and subsequent opening of glutamate-permeable, two-pore domain potassium channel TREK-1 through direct interaction between G(βγ) and N terminus of TREK-1.
Metabolic and thermal stimuli control K(2P)2.1 (TREK-1) through modular sensory and gating domains.
Minor et al., San Francisco, United States. In Embo J, 2012
A mechanism for signal transduction within K(2P)2.1 (TREK-1) in which there is a clear crosstalk between the C-type gate and intracellular Ct domain.
Expression of the two pore domain potassium channel TREK-1 in human intervertebral disc cells.
Maffulli et al., Stoke-on-Trent, United Kingdom. In Curr Stem Cell Res Ther, 2012
TREK-1 is expressed by both nucleus pulposus and annulus fibrosus cells of the human intervertebral disc.
Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABA(B) signaling.
Isacoff et al., Berkeley, United States. In Neuron, 2012
We find that TREK1, typically considered to be a leak channel, contributes to the hippocampal GABA(B) response.
Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice.
Brand et al., Würzburg, Germany. In J Clin Invest, 2012
Popdc1 and Popdc2 proteins interact with the potassium channel TREK-1, which leads to increased cell surface expression and enhanced current density
Characterization of serotonin neurotransmission in knockout mice: implications for major depression.
Gobbi et al., Montréal, Canada. In Rev Neurosci, 2011
This review presented that the TERK-1 knockout mice show a correlation between 5-HT firing rate and
Molecular background of leak K+ currents: two-pore domain potassium channels.
Czirják et al., Budapest, Hungary. In Physiol Rev, 2010
Basic physicochemical parameters (e.g., pH, temperature, membrane stretch) and also several intracellular signaling pathways substantially and specifically modulate the different members of the six K(2P) channel subfamilies (TWIK, TREK, TASK, TALK, THIK, and TRESK).
The neuronal background K2P channels: focus on TREK1.
Honoré, Antibes, France. In Nat Rev Neurosci, 2007
TREK1, the most thoroughly studied K(2P) channel, has a key role in the cellular mechanisms of neuroprotection, anaesthesia, pain and depression--{REVIEW}
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