Regulation of mTORC1 by PI3K signaling.
Boston, United States. In Trends Cell Biol, Sep 2015
We focus on how PI3K-dependent activation of Akt and spatial regulation of the tuberous sclerosis complex (TSC) complex (TSC complex) [composed of TSC1, TSC2, and Tre2-Bub2-Cdc16-1 domain family member 7 (TBC1D7)] switches on Rheb at the lysosome, where mTORC1 is activated.
AMPKα is critical for enhancing skeletal muscle fatty acid utilization during in vivo exercise in mice.
Copenhagen, Denmark. In Faseb J, May 2015
A decreased muscle protein expression of CD36 (cluster of differentiation 36) and FABPpm (plasma membrane fatty acid binding protein) (by ∼17-40%), together with fully abolished TBC1D1 (tre-2/USP6, BUB2, cdc16 domain family member 1) Ser(237) phosphorylation during contraction/exercise in AMPKα mdKO mice, may impair FA transport capacity and FA transport protein translocation to sarcolemma, respectively.
Long lifespan in worms with long telomeric DNA.
Seoul, South Korea. In Nat Genet, 2004
We examined the effect of telomere length on lifespan by overexpressing HRP-1, a telomere-binding protein, which gradually increased telomere length in worms.