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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Thioredoxin reductase 2

TRbeta, TR beta 1
Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: erbA, CAN, ACID, HAD, V1a
Papers on TRbeta
Thyroid Hormone Regulates the mRNA Expression of Small Heterodimer Partner through Liver Receptor Homolog-1.
New
Park et al., Seoul, South Korea. In Endocrinol Metab (seoul), Nov 2015
Liver receptor homolog-1 (LRH-1) increased the promoter activity of SHP; however, this increased activity was markedly decreased after TRbeta/RXRalpha/T3 administration.
Nanostructured sensors containing immobilized nuclear receptors for thyroid hormone detection.
Zucolotto et al., In J Biomed Nanotechnol, 2014
Thyroid hormone receptors (TRs) are members of the nuclear receptors (NRs) superfamily, being encoded by two genes: TRa and TRbeta.
[Thyroid disease caused by receptor abnormality].
Review
Murakami et al., In Rinsho Byori, 2014
Resistance to thyroid hormone is mainly caused by a mutation in the thyroid hormone receptor beta (TRbeta) gene.
New avenues for regulation of lipid metabolism by thyroid hormones and analogs.
Review
de Lange et al., Caserta, Italy. In Front Physiol, 2013
The end of the previous century saw the exploration of TH mimetics that specifically bind to TR beta in order to prevent cardiac disturbances, and TH derivatives such as 3,5-diiodo-L-thyronine (T2), that possess interesting biological activities.
Receptors of thyroid hormones.
Review
Zambrano et al., Madrid, Spain. In Pediatr Endocrinol Rev, 2013
The important physiological actions of the thyroid hormones are mediated by binding to nuclear thyroid hormone receptors (TRs), encoded by two genes TRalpha and TRbeta.
Thyroid hormone receptor (TR)alpha and TRbeta expression in breast cancer.
Jeschke et al., München, Germany. In Histol Histopathol, 2013
However, the relation between thyroid receptor (TR) expression and breast cancer remains unknown so far.
[Thyroid hormones and their precursors I. Biochemical properties].
Review
Noszál et al., Budapest, Hungary. In Acta Pharm Hung, 2012
There are two major thyroid hormone receptor (TR) isoforms, alfa (TRalpha) and beta (TRbeta).
Fundamentally distinct roles of thyroid hormone receptor isoforms in a thyrotroph cell line are due to differential DNA binding.
GeneRIF
Wondisford et al., São Paulo, Brazil. In Mol Endocrinol, 2012
the differential effects of thyroid hormone receptor isoforms on Tshb expression may be based on their differential DNA-binding affinity to the promoter.
Advanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptor β gene due to activation of Wnt/β-catenin protein signaling.
GeneRIF
Williams et al., Bethesda, United States. In J Biol Chem, 2012
Advanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptor beta gene due to activation of Wnt/beta-catenin protein signaling.
Thyroid hormone receptors control developmental maturation of the middle ear and the size of the ossicular bones.
GeneRIF
Forrest et al., Bethesda, United States. In Endocrinology, 2012
Thyroid hormone receptors control developmental maturation of the middle ear and the size of the ossicular bones
The Δ337T mutation on the TRβ causes alterations in growth, adiposity, and hepatic glucose homeostasis in mice.
GeneRIF
Ortiga-Carvalho et al., Rio de Janeiro, Brazil. In J Endocrinol, 2011
The Delta337T mutation on the TRbeta causes alterations in growth, adiposity, and hepatic glucose homeostasis in mice.
Generation of fluorescent zebrafish to study endocrine disruption and potential crosstalk between thyroid hormone and corticosteroids.
Prunet et al., Rennes, France. In Aquat Toxicol, 2011
The expression of genes involved in the TH axis (TR-alpha, TR-beta, TSH) and the corticoid axis (GR and MR) was followed by q-PCR after T3 or BPA exposure (24 or 48h) and at different developmental stages (0, 1, or 5 days post-fertilization).
Complete activation of thyroid hormone receptor β by T3 is essential for normal cochlear function and morphology in mice.
GeneRIF
Ortiga-Carvalho et al., Chicago, United States. In Cell Physiol Biochem, 2010
mutations in thyroid hormone receptor beta were deleterious to tectorial membrane development and led to important alterations in cochlear morphology and loss of cochlear function
A case of resistance to thyroid hormone with thyroid cancer.
Kim et al., Seoul, South Korea. In J Korean Med Sci, 2010
The magnitude of RTH is caused by mutations in the thyroid hormone receptor beta (TR beta) gene.
A mutation in thyroid hormone receptor beta causing "resistance to thyroid hormone" in a neonate.
Turan et al., İstanbul, Turkey. In Minerva Pediatr, 2010
The main defects are due to mutations in thyroid hormone receptor beta (TRbeta).
Molecular aspects of thyroid hormone actions.
Review
Impact
Davis et al., Bethesda, United States. In Endocr Rev, 2010
Two TR genes, alpha and beta, encode four T(3)-binding receptor isoforms (alpha1, beta1, beta2, and beta3).
C-fin: a cultured frog tadpole tail fin biopsy approach for detection of thyroid hormone-disrupting chemicals.
Helbing et al., Victoria, Canada. In Environ Toxicol Chem, 2010
Chemical exposure was performed +/- 10 nM 3,3',5-triiodothyronine and real-time quantitative polymerase chain reaction (QPCR) of two TH-responsive transcripts, TH receptor beta (TRbeta) and the Rana larval keratin type I (RLKI), was performed.
3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone.
Impact
Grandy et al., San Francisco, United States. In Nat Med, 2004
In target tissues, T(4) is enzymatically deiodinated to 3,5,3'-triiodothyronine (T(3)), a high-affinity ligand for the nuclear TH receptors TR alpha and TR beta, whose activation controls normal vertebrate development and physiology.
A thyroid hormone receptor that is required for the development of green cone photoreceptors.
Impact
Forrest et al., New York City, United States. In Nat Genet, 2001
Thyroid hormone receptor beta 2 (TR beta 2) is a ligand-activated transcription factor that is expressed in the outer nuclear layer of the embryonic retina.
Thyroid hormone receptor beta is essential for development of auditory function.
Impact
Curran et al., New York City, United States. In Nat Genet, 1996
We demonstrate that Tr beta-deficient (Thrb-/-) mice exhibit a permanent deficit in auditory function across a wide range of frequencies, although they show no other overt neurological defects.
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