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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Tribbles homolog 3

TRB3, Sink, TRIB3
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Akt, Insulin, V1a, CHOP, ACID
Papers on TRB3
Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation.
New
Impact
Johnson et al., Canada. In Cell Metab, Feb 2016
Transcriptome, proteome, and network analysis revealed alleviation of chronic endoplasmic reticulum (ER) stress, indicated by reduced Ddit3, Trib3, and Atf4 expression; reduced Xbp1 splicing; and reduced phospho-eIF2α.
Central Resistin/TLR4 impairs adiponectin signaling contributing to insulin and FGF21 resistance.
New
Taouis et al., Orsay, France. In Diabetes, Feb 2016
Here, we investigated whether central resistin promotes insulin resistance through the impairment of adiponectin and FGF21 signaling.We showed that chronic ICV resistin infusion down-regulated both hypothalamic and hepatic APPL1, a key protein in adiponectin signaling, associated with decreased Akt/APPL1 interaction and an increased Akt association with its endogenous inhibitor TRB3.
Complementary activities of TELOMERE REPEAT BINDING proteins and Polycomb Group complexes in transcriptional regulation of target genes.
New
Turck et al., Köln, Germany. In Plant Cell, Jan 2016
Two enhancing mutations were mapped to TELOMERE REPEAT BINDING PROTEIN (TRB) 1 and its paralog TRB3.
Repetitive exposure to low-dose X-irradiation attenuates testicular apoptosis in type 2 diabetic rats, likely via Akt-mediated Nrf2 activation.
New
Cai et al., Changchun, China. In Mol Cell Endocrinol, Jan 2016
UNASSIGNED: To determine whether repetitive exposure to low-dose radiation (LDR) attenuates type 2 diabetes (T2DM)-induced testicular apoptotic cell death in a T2DM rat model, we examined the effects of LDR exposure on diabetic and age-matched control rats.
The new antitumor drug ABTL0812 inhibits the Akt/mTORC1 axis by upregulating Tribbles-3 pseudokinase.
New
Lizcano et al., Barcelona, Spain. In Clin Cancer Res, Jan 2016
EXPERIMENTAL DESIGN: We investigated the effect of ABTL0812 on cancer cell death, proliferation and modulation of intracellular signaling pathways, using human lung (A549) and pancreatic (MiaPaCa-2) cancer cells and tumor xenografts.
Source-Sink Communication: Regulated by Hormone, Nutrient, and Stress Cross-Signaling.
Review
New
Ho et al., Taipei, Taiwan. In Trends Plant Sci, Dec 2015
Communication between source organs (exporters of photoassimilates) and sink organs (importers of fixed carbon) has a pivotal role in carbohydrate assimilation and partitioning during plant growth and development.
Regulation Effects of Water and Nitrogen on the Source-Sink Relationship in Potato during the Tuber Bulking Stage.
New
Li et al., China. In Plos One, Dec 2015
The source-sink relationship determines crop yield, and it is largely regulated by water and nutrients in agricultural production.
The critical role of Akt in cardiovascular function.
Review
New
Su et al., Augusta, United States. In Vascul Pharmacol, Nov 2015
Akt kinase, a member of AGC kinases, is important in many cellular functions including proliferation, migration, cell growth and metabolism.
Oncosuppressive functions of tribbles pseudokinase 3.
Review
New
Velasco et al., Madrid, Spain. In Biochem Soc Trans, Nov 2015
Tribbles pseudokinase 3 (TRIB3) belongs to the tribbles family of pseudokinases.
Tribbles in normal and malignant haematopoiesis.
Review
New
Pear et al., Philadelphia, United States. In Biochem Soc Trans, Nov 2015
The three mammalian Tribbles homologues, Trib1, Trib2 and Trib3 are characterized by conserved motifs, including a pseudokinase domain and a C-terminal E3 ligase-binding domain.
The TRIB3 Q84R polymorphism, insulin resistance and related metabolic alterations.
Review
New
Trischitta et al., Roma, Italy. In Biochem Soc Trans, Nov 2015
This review will be focused on studies addressing the role of genetic variability of TRIB3, an inhibitor of insulin signalling at the AKT level on insulin resistance and several related abnormalities.
Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling.
Impact
Tabas et al., New York City, United States. In Cell Metab, 2014
We now report a major role for hepatic CaMKII, a calcium-responsive kinase that is activated in obesity.
ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation.
Impact
Simon et al., Philadelphia, United States. In Cancer Cell, 2012
Using MYCN-amplified neuroblastoma as a model, we identify PUMA, NOXA, and TRB3 as executors of Gln-starved cells.
The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases.
Review
Impact
Trischitta et al., Italy. In Endocr Rev, 2012
Tribbles homolog 3 (TRIB3) is a 45-kDa pseudokinase binding to and inhibiting Akt, a key mediator of insulin signaling.
The tribbles gene family and lipoprotein metabolism.
GeneRIF
Kiss-Toth et al., Sheffield, United Kingdom. In Curr Opin Lipidol, 2012
Studies indicate tribbles 1 and tribbles 3 as regulators of lipid level and disease susceptibility genes in metabolic syndrome and type 2 diabetes.
Silence of TRIB3 suppresses atherosclerosis and stabilizes plaques in diabetic ApoE-/-/LDL receptor-/- mice.
GeneRIF
Zhang et al., China. In Diabetes, 2012
Silence of TRIB3 would diminish atherosclerotic burden and increase the plaque stability in diabetic mice.
TRB3 gene silencing alleviates diabetic cardiomyopathy in a type 2 diabetic rat model.
GeneRIF
Zhang et al., China. In Diabetes, 2011
investigation into whether TRB3 plays a major role in diabetic cardiomyopathy (DCM) and the mechanisms involved: TRB3 gene silencing may exert a protective effect on DCM by improving selective insulin resistance.
TRB3 mediates homocysteine-induced inhibition of endothelial cell proliferation.
GeneRIF
Zou et al., Beijing, China. In J Cell Physiol, 2011
TRB3 is a critical molecule in the homocysteine-mediated cell-cycle arrest in endothelial cells.
TRB3 interacts with SMAD3 promoting tumor cell migration and invasion.
GeneRIF
Hu et al., Beijing, China. In J Cell Sci, 2011
knockdown of endogenous TRB3 expression inhibited the migration and invasion of tumor cells in vitro
APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice.
Impact
Xu et al., Hong Kong, Hong Kong. In Cell Metab, 2009
Hepatic insulin resistance is the major contributor to fasting hyperglycemia in type 2 diabetes.
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