Central Resistin/TLR4 impairs adiponectin signaling contributing to insulin and FGF21 resistance.
Orsay, France. In Diabetes, Feb 2016
Here, we investigated whether central resistin promotes insulin resistance through the impairment of adiponectin and FGF21 signaling.We showed that chronic ICV resistin infusion down-regulated both hypothalamic and hepatic APPL1, a key protein in adiponectin signaling, associated with decreased Akt/APPL1 interaction and an increased Akt association with its endogenous inhibitor TRB3.
Tribbles in normal and malignant haematopoiesis.
Philadelphia, United States. In Biochem Soc Trans, Nov 2015
The three mammalian Tribbles homologues, Trib1, Trib2 and Trib3 are characterized by conserved motifs, including a pseudokinase domain and a C-terminal E3 ligase-binding domain.