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Mediator complex subunit 24

TRAP100, Med24, DRIP100, mTRAP100
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene may form a submodule of the mediator complex that magnifies the effects of activators on the general transcription machinery. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: POLYMERASE, CAN, fibrillin-1, PPAR, TRAP240
Papers on TRAP100
Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.
New
Vahteristo et al., Helsinki, Finland. In Prostate, Jan 2016
Instead, the L1224F mutation was shown to affect interactions between MED12 and other Mediator components (MED1, MED13, MED13L, MED14, MED15, MED17, and MED24).
SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells.
Impact
Ng et al., Singapore, Singapore. In Nat Cell Biol, 2013
Importantly, we confirmed that SON regulates the proper splicing of transcripts encoding for pluripotency regulators such as OCT4, PRDM14, E4F1 and MED24.
Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes.
Sterne et al., Bristol, United Kingdom. In J Allergy Clin Immunol, 2013
SNPs across the whole region show strong evidence of association with differential levels of expression at GSDML, IKZF3, and MED24, as well as ORMDL3.
Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma.
Weidinger et al., München, Germany. In Allergy, 2012
Likewise, asthma risk alleles from the PDED3 and MED24 genes at the asthma susceptibility locus 17q21 were associated with increased concentrations of various phosphatidylcholines with consistent effect directions.
Mediator subunits MED1 and MED24 cooperatively contribute to pubertal mammary gland development and growth of breast carcinoma cells.
GeneRIF
Ito et al., Kōbe, Japan. In Mol Cell Biol, 2012
functional communications between the MED1 subunit and the MED24-containing submodule that mediate estrogen receptor functions and growth of both normal mammary epithelial cells and breast carcinoma cells.
Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network.
GeneRIF
Electronic Medical Records and Genomics (eMERGE) Network et al., Seattle, United States. In Hum Genet, 2012
Study identified significantly white blood cell count (WBC) level associated SNPs of three separate genes GSDMA, MED24, and PSMD3 in European continent (EA) subjects.
Med24 and Mdh2 are required for Drosophila larval salivary gland cell death.
GeneRIF
Thummel et al., Salt Lake City, United States. In Dev Dyn, 2010
Med24 and Mdh2 are required for Drosophila larval salivary gland cell death
Exon-level transcriptome profiling in murine breast cancer reveals splicing changes specific to tumors with different metastatic abilities.
Majewski et al., Montréal, Canada. In Plos One, 2009
We chose ten predicted splice variants for RT-PCR validation, eight of which were successfully confirmed (MED24, MFI2, SRRT, CD44, CLK1 and HNRNPH1).
PRIC295, a Nuclear Receptor Coactivator, Identified from PPARα-Interacting Cofactor Complex.
Reddy et al., Chicago, United States. In Ppar Res, 2009
Here, we report the identification and characterization of PPARα-interacting cofactor (PRIC)-295 (PRIC295), a novel coactivator protein, and show that it interacts with the Med1 and Med24 subunits of the Mediator complex.
A genetic screen identifies new regulators of steroid-triggered programmed cell death in Drosophila.
Bashirullah et al., Salt Lake City, United States. In Genetics, 2008
Three were mapped to specific genes: CG5146, which encodes a protein of unknown function, Med24, which encodes a component of the RNA polymerase II mediator complex, and CG7998, which encodes a putative mitochondrial malate dehydrogenase.
Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex.
Bourbon, Toulouse, France. In Nucleic Acids Res, 2008
Saccharomyces cerevisiae Med2, Med3/Pgd1 and Med5/Nut1 subunits are apparent homologs of metazoan Med29/Intersex, Med27/Crsp34 and Med24/Trap100, respectively, and these and other 30 identified human MED subunits have detectable counterparts in the amoeba Dictyostelium discoideum, indicating that none is specific to metazoans.
Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression.
Roeder et al., Bethesda, United States. In Mol Cell Biol, 2008
However, PPARgamma shows significantly reduced transcriptional activity in cells deficient for a subunit (MED24/TRAP100) important for the integrity of the Mediator complex, indicating a general Mediator requirement for PPARgamma function.
Differential roles of transcriptional mediator complex subunits Crsp34/Med27, Crsp150/Med14 and Trap100/Med24 during zebrafish retinal development.
Driever et al., Freiburg, Germany. In Genetics, 2006
To explore the role of the mediator in the control of retinal differentiation, we employed two additional mutations disrupting the mediator subunits Trap100/Med24 and Crsp150/Med14.
lessen encodes a zebrafish trap100 required for enteric nervous system development.
GeneRIF
Shepherd et al., Atlanta, United States. In Development, 2006
Data demonstrate that lsn/trap100 is not required for initial steps of cranial neural crest development and migration, but is essential for later proliferation of enteric nervous system precursors in the intestine.
Characterization of a male-predominant antisense transcript underexpressed in hybrids of Drosophila pseudoobscura and D. persimilis.
Donze et al., Baton Rouge, United States. In Genetics, 2003
Here, we obtained the full sequence of this 1330-bp transcript and determined that it is an antisense message with high sequence similarity to the D. melanogaster TRAP100 gene, part of the Mediator protein complex that regulates transcriptional initiation during development.
The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development.
GeneRIF
Roeder et al., New York City, United States. In Embo J, 2002
genetic ablation of mouse Trap100 results in attenuation of transcriptional activation and loss of TRAP95, TRAP150beta, and TRAP100 from the TRAP/Mediator complex.
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