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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 May 2016.

Transketolase

transketolase
This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, CK7, fibrillin-1
Papers on transketolase
Production of superoxide/hydrogen peroxide by the mitochondrial 2-oxoadipate dehydrogenase complex.
New
Brand et al., Novato, United States. In Free Radic Biol Med, Jan 2016
UNASSIGNED: In humans, mutations in dehydrogenase E1 and transketolase domain containing 1 (DHTKD1) are associated with neurological abnormalities and accumulation of 2-oxoadipate, 2-aminoadipate, and reactive oxygen species.
Substrate inhibition of transketolase.
New
Kochetov et al., Moscow, Russia. In Biochim Biophys Acta, Jan 2016
UNASSIGNED: We studied the influence of the acceptor substrate of transketolase on the activity of the enzyme in the presence of reductants.
Analysis of circulating CD14+/CD16+ monocyte-derived macrophages (MDMs) in the peripheral blood of patients with oral squamous cell carcinoma.
New
Reinert et al., Tübingen, Germany. In Oral Surg Oral Med Oral Pathol Oral Radiol, Dec 2015
Moreover, epitope detection in monocytes (EDIM) technology was used to detect biomarkers Apo10 and transketolase-like-1 in CD14+/CD16+ MDMs.
[Cloning, expression and bioinformatics analysis of pyruvate dehydrogenase of Echinococcus granulosus].
New
Hu et al., In Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi, Aug 2015
The bioinformatics analysis revealed that EgPDH was a classical secreted protein and contained transketolase domain.
Sweet siblings with different faces: the mechanisms of FBP and F6P aldolase, transaldolase, transketolase and phosphoketolase revisited in light of recent structural data.
Review
Tittmann, Göttingen, Germany. In Bioorg Chem, 2014
In contrast, transketolase and phosphoketolase make use of the bioorganic cofactor thiamin diphosphate to cleave the preceding C2-C3 bond of ketose phosphates.
The role of trace elements, thiamin (e) and transketolase in autism and autistic spectrum disorder.
Review
Lonsdale et al., Cleveland, United States. In Front Biosci (elite Ed), 2014
We hypothesize that altered thiol metabolism from heavy metal toxicity, one of the key mechanisms for oxidative stress production, may be responsible for the biochemical alterations in transketolase, dysautonomia and abnormal thiamine homeostasis.
Structure and functioning mechanism of transketolase.
Review
Solovjeva et al., Moscow, Russia. In Biochim Biophys Acta, 2014
Transketolase, discovered independently by Racker and Horecker in 1953 (and named by Racker) [1], did not receive much attention until 1992, when crystal X-ray structure analysis of the enzyme from Saccharomyces cerevisiae was performed [2].
Engineering stereoselectivity of ThDP-dependent enzymes.
Review
Pohl et al., London, United Kingdom. In Febs J, 2013
Both structurally different enzyme families differ also in stereoselectivity: enzymes from the decarboxylase family are predominantly R-selective, whereas those from the transketolase family are S-selective.
[Vitamin B1 (thiamine)].
Review
Guilland, Dijon, France. In Rev Prat, 2013
The biological exploration of vitamin B1 status is based on the measurement of thiamine pyrophosphate concentration or of the activity of a thiamine-dependent enzyme, transketolase, in erythrocytes.
Sub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate.
Impact
Tittmann et al., Göttingen, Germany. In Nat Chem, 2013
Here, we report sub-ångström-resolution crystal structures of genuine covalent reaction intermediates of transketolase.
Antihypertensive role of tissue kallikrein in hyperaldosteronism in the mouse.
GeneRIF
Bouby et al., Paris, France. In Endocrinology, 2012
The study suggests that kallikrein plays an antihypertensive role in hyperaldosteronism.
Characterization of non-oxidative transaldolase and transketolase enzymes in the pentose phosphate pathway with regard to xylose utilization by recombinant Saccharomyces cerevisiae.
GeneRIF
Yano et al., Hiroshima, Japan. In Enzyme Microb Technol, 2012
characterization of NQM1 and TKL2, together with TAL1 and TKL1, regarding their roles in xylose utilization and fermentation
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
GeneRIF
Yaspo et al., Berlin, Germany. In J Biol Chem, 2011
TKT is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
Riboneogenesis in yeast.
Impact
Caudy et al., Princeton, United States. In Cell, 2011
Riboneogenesis begins with synthesis, by the combined action of transketolase and aldolase, of the seven-carbon bisphosphorylated sugar sedoheptulose-1,7-bisphosphate.
Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy.
GeneRIF
Kanková et al., Brno, Czech Republic. In Nephrol Dial Transplant, 2011
Single Nucleotide Polymorphism in transketolase is associated with diabetic nephropathy.
The crystal structure of human transketolase and new insights into its mode of action.
GeneRIF
Tittmann et al., Halle, Germany. In J Biol Chem, 2010
The crystal structure of human transketolase and new insights into its mode of action.
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.
Impact
Brownlee et al., Mannheim, Germany. In Nat Med, 2003
We have discovered that the lipid-soluble thiamine derivative benfotiamine can inhibit these three pathways, as well as hyperglycemia-associated NF-kappaB activation, by activating the pentose phosphate pathway enzyme transketolase, which converts glyceraldehyde-3-phosphate and fructose-6-phosphate into pentose-5-phosphates and other sugars.
Thiamine deficiency and malaria in adults from southeast Asia.
Impact
White et al., Bangkok, Thailand. In Lancet, 1999
The activation coefficient for transketolase activity in erythrocytes was used to measure thiamine deficiency.
The effect of acetaldehyde on human brain transketolase activity.
Pratt et al., London, United Kingdom. In Addict Biol, 1997
In the present investigation the direct effect of ACH was studied on the activity of transketolase, a thiaminedependent enzyme, as well as two non-thiamine-dependent enzymes (aspartate aminotransferase and lactate dehydrogenase), isolated from five control human brains.
Pathway engineering for the production of aromatic compounds in Escherichia coli.
Impact
Valle et al., Ecatepec, Mexico. In Nat Biotechnol, 1996
This increased carbon commitment to the aromatic pathway was enhanced still further upon amplification of the E. coli tktA gene that encodes for a transketolase involved in the biosynthesis of E4P.
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