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Transketolase

transketolase
This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, CK7, fibrillin-1
Papers on transketolase
Bioinformatic and metabolomic analysis reveals miR-155 regulates thiamine level in breast cancer.
New
Chang et al., Seoul, South Korea. In Cancer Lett, 28 Mar 2015
Thiamine, commonly known as vitamin B1, is one of critical cofactors for energy metabolic enzymes including pyruvate dehydrogenase, alpha ketoglutarate dehydrogenase, and transketolase.
Production of cinnamic and p -hydroxycinnamic acid from sugar mixtures with engineered Escherichia coli.
New
Gosset et al., In Microb Cell Fact, 16 Feb 2015
However, sustainable production processes should preferably be based on the use of waste material such as lignocellulosic hydrolysates.ResultsIn this study, E. coli strains with active (W3110) and inactive phosphoenolpyruvate:sugar phosphotransferase system (PTS) (VH33) were engineered for CA and pHCA production by transforming them with plasmids expressing genes encoding phenylalanine/tyrosine ammonia lyase (PAL/TAL) enzymes from Rhodotorula glutinis or Arabidopsis thaliana as well as genes aroG fbr and tktA, encoding a feedback inhibition resistant version of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase and transketolase, respectively.
Expression patterns and prognostic role of transketolase-like 1 in muscle-invasive bladder cancer.
New
Todenhöfer et al., Tübingen, Germany. In World J Urol, 09 Feb 2015
The transketolase-like 1 gene (TKTL1) encodes an enzyme representing an essential component of this pathway.
Thiamine and magnesium deficiencies: Keys to disease.
New
Lonsdale, Cleveland, United States. In Med Hypotheses, 15 Jan 2015
Transketolase, dependent on thiamine and magnesium, occurs twice in the oxidative pentose pathway, important in production of reducing equivalents.
The role of trace elements, thiamin (e) and transketolase in autism and autistic spectrum disorder.
New
Lonsdale et al., Cleveland, United States. In Front Biosci (elite Ed), 31 Dec 2014
We hypothesize that altered thiol metabolism from heavy metal toxicity, one of the key mechanisms for oxidative stress production, may be responsible for the biochemical alterations in transketolase, dysautonomia and abnormal thiamine homeostasis.
Structure and functioning mechanism of transketolase.
Review
New
Solovjeva et al., Moscow, Russia. In Biochim Biophys Acta, Sep 2014
Transketolase, discovered independently by Racker and Horecker in 1953 (and named by Racker) [1], did not receive much attention until 1992, when crystal X-ray structure analysis of the enzyme from Saccharomyces cerevisiae was performed [2].
Engineering stereoselectivity of ThDP-dependent enzymes.
Review
Pohl et al., London, United Kingdom. In Febs J, 2013
Both structurally different enzyme families differ also in stereoselectivity: enzymes from the decarboxylase family are predominantly R-selective, whereas those from the transketolase family are S-selective.
Using site-saturation mutagenesis to explore mechanism and substrate specificity in thiamin diphosphate-dependent enzymes.
Review
McLeish et al., Indianapolis, United States. In Febs J, 2013
We also summarize the results obtained when SSM was used to evolve new substrate specificity and/or enantioselectivity in ThDP-dependent enzymes such as benzoylformate decarboxylase, transketolase, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase and the E1 component of the 2-oxoglutarate dehydrogenase complex.
[Vitamin B1 (thiamine)].
Review
Guilland, Dijon, France. In Rev Prat, 2013
The biological exploration of vitamin B1 status is based on the measurement of thiamine pyrophosphate concentration or of the activity of a thiamine-dependent enzyme, transketolase, in erythrocytes.
Sub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate.
Impact
Tittmann et al., Göttingen, Germany. In Nat Chem, 2013
Here, we report sub-ångström-resolution crystal structures of genuine covalent reaction intermediates of transketolase.
The role of thiamine in cancer: possible genetic and cellular signaling mechanisms.
Review
Nguyễn et al., Westminster, United States. In Cancer Genomics Proteomics, 2013
Genetic studies have helped identify a number of factors that link thiamine to cancer, including the solute carrier transporter (SLC19) gene, transketolase, transcription factor p53, poly(ADP-ribose) polymerase-1 gene, and the reduced form of nicotinamide adenine dinucleotide phosphate.
Antihypertensive role of tissue kallikrein in hyperaldosteronism in the mouse.
GeneRIF
Bouby et al., Paris, France. In Endocrinology, 2012
The study suggests that kallikrein plays an antihypertensive role in hyperaldosteronism.
Characterization of non-oxidative transaldolase and transketolase enzymes in the pentose phosphate pathway with regard to xylose utilization by recombinant Saccharomyces cerevisiae.
GeneRIF
Yano et al., Hiroshima, Japan. In Enzyme Microb Technol, 2012
characterization of NQM1 and TKL2, together with TAL1 and TKL1, regarding their roles in xylose utilization and fermentation
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
GeneRIF
Yaspo et al., Berlin, Germany. In J Biol Chem, 2011
TKT is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
Riboneogenesis in yeast.
Impact
Caudy et al., Princeton, United States. In Cell, 2011
Riboneogenesis begins with synthesis, by the combined action of transketolase and aldolase, of the seven-carbon bisphosphorylated sugar sedoheptulose-1,7-bisphosphate.
Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy.
GeneRIF
Kanková et al., Brno, Czech Republic. In Nephrol Dial Transplant, 2011
Single Nucleotide Polymorphism in transketolase is associated with diabetic nephropathy.
The crystal structure of human transketolase and new insights into its mode of action.
GeneRIF
Tittmann et al., Halle, Germany. In J Biol Chem, 2010
The crystal structure of human transketolase and new insights into its mode of action.
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.
Impact
Brownlee et al., Mannheim, Germany. In Nat Med, 2003
We have discovered that the lipid-soluble thiamine derivative benfotiamine can inhibit these three pathways, as well as hyperglycemia-associated NF-kappaB activation, by activating the pentose phosphate pathway enzyme transketolase, which converts glyceraldehyde-3-phosphate and fructose-6-phosphate into pentose-5-phosphates and other sugars.
Thiamine deficiency and malaria in adults from southeast Asia.
Impact
White et al., Bangkok, Thailand. In Lancet, 1999
The activation coefficient for transketolase activity in erythrocytes was used to measure thiamine deficiency.
Pathway engineering for the production of aromatic compounds in Escherichia coli.
Impact
Valle et al., Ecatepec, Mexico. In Nat Biotechnol, 1996
This increased carbon commitment to the aromatic pathway was enhanced still further upon amplification of the E. coli tktA gene that encodes for a transketolase involved in the biosynthesis of E4P.
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