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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.


This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, CK7, fibrillin-1
Papers on transketolase
Site-specific integration and constitutive expression of key genes into Escherichia coli chromosome increases shikimic acid yields.
Zhu et al., Shanghai, China. In Enzyme Microb Technol, 31 Jan 2016
Herein, crucial genes aroG, aroB, tktA, aroE (encoding 3-deoxy-d-arabinoheptulosonate-7-phosphate synthase, dehydroquinate synthase, transketolase and shikimate dehydrogenase, respectively) of SA pathway and glk, galP (encoding glucokinase and galactose permease) were integrated into the locus of ptsHIcrr (phosphoenolpyruvate: carbohydrate phosphotransferase system operon) in a shikimate kinase genetic defect strain Escherichia coli BW25113 (ΔaroL/aroK, DE3).
Transketolase activity modulates glycerol-3-phosphate levels in Escherichia coli.
Harinarayanan et al., Hyderābād, India. In Mol Microbiol, 21 Jan 2016
UNASSIGNED: Transketolase activity provides an important link between the metabolic pathways of glycolysis and pentose phosphate shunt and catalyzes inter-conversions between pentose phosphates and glycolytic intermediates.
Production of superoxide/hydrogen peroxide by the mitochondrial 2-oxoadipate dehydrogenase complex.
Brand et al., Novato, United States. In Free Radic Biol Med, 18 Jan 2016
UNASSIGNED: In humans, mutations in dehydrogenase E1 and transketolase domain containing 1 (DHTKD1) are associated with neurological abnormalities and accumulation of 2-oxoadipate, 2-aminoadipate, and reactive oxygen species.
Substrate inhibition of transketolase.
Kochetov et al., Moscow, Russia. In Biochim Biophys Acta, 17 Jan 2016
UNASSIGNED: We studied the influence of the acceptor substrate of transketolase on the activity of the enzyme in the presence of reductants.
The network of surface-displayed glycolytic enzymes in Mycoplasma pneumoniae and their interactions with human plasminogen.
Dumke et al., Dresden, Germany. In Infect Immun, 14 Jan 2016
Eight glycolytic enzymes, pyruvate dehydrogenase A-C (PdhA-C), glyceraldehyde-3-phosphate dehydrogenase (GapA), lactate dehydrogenase (Ldh), phosphoglycerate mutase (Pgm), pyruvate kinase (Pyk) and transketolase (Tkt), were confirmed as surface-expressed and all are able to interact with plasminogen.
New approaches for improving the production of the 1st and 2nd generation ethanol by yeast.
Sibirny et al., L'viv, Ukraine. In Acta Biochim Pol, 30 Dec 2015
Increase in ethanol yield and productivity from xylose was also achieved by overexpression of genes coding for the peroxisomal enzymes: transketolase (DAS1) and transaldolase (TAL2), and deletion of the ATG13 gene.
Analysis of circulating CD14+/CD16+ monocyte-derived macrophages (MDMs) in the peripheral blood of patients with oral squamous cell carcinoma.
Reinert et al., Tübingen, Germany. In Oral Surg Oral Med Oral Pathol Oral Radiol, 04 Dec 2015
Moreover, epitope detection in monocytes (EDIM) technology was used to detect biomarkers Apo10 and transketolase-like-1 in CD14+/CD16+ MDMs.
[Cloning, expression and bioinformatics analysis of pyruvate dehydrogenase of Echinococcus granulosus].
Hu et al., In Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi, Aug 2015
The bioinformatics analysis revealed that EgPDH was a classical secreted protein and contained transketolase domain.
Gender-specific effects of intrauterine growth restriction on the adipose tissue of adult rats: a proteomic approach.
Ribeiro et al., São Paulo, Brazil. In Proteome Sci, 2014
The restricted females showed down-regulated levels of L-lactate dehydrogenase perilipin-1, mitochondrial branched-chain alpha-keto acid dehydrogenase E1, and transketolase.
Sub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate.
Tittmann et al., Göttingen, Germany. In Nat Chem, 2013
Here, we report sub-ångström-resolution crystal structures of genuine covalent reaction intermediates of transketolase.
Antihypertensive role of tissue kallikrein in hyperaldosteronism in the mouse.
Bouby et al., Paris, France. In Endocrinology, 2012
The study suggests that kallikrein plays an antihypertensive role in hyperaldosteronism.
Characterization of non-oxidative transaldolase and transketolase enzymes in the pentose phosphate pathway with regard to xylose utilization by recombinant Saccharomyces cerevisiae.
Yano et al., Hiroshima, Japan. In Enzyme Microb Technol, 2012
characterization of NQM1 and TKL2, together with TAL1 and TKL1, regarding their roles in xylose utilization and fermentation
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Yaspo et al., Berlin, Germany. In J Biol Chem, 2011
TKT is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
Riboneogenesis in yeast.
Caudy et al., Princeton, United States. In Cell, 2011
Riboneogenesis begins with synthesis, by the combined action of transketolase and aldolase, of the seven-carbon bisphosphorylated sugar sedoheptulose-1,7-bisphosphate.
Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy.
Kanková et al., Brno, Czech Republic. In Nephrol Dial Transplant, 2011
Single Nucleotide Polymorphism in transketolase is associated with diabetic nephropathy.
The crystal structure of human transketolase and new insights into its mode of action.
Tittmann et al., Halle, Germany. In J Biol Chem, 2010
The crystal structure of human transketolase and new insights into its mode of action.
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.
Brownlee et al., Mannheim, Germany. In Nat Med, 2003
We have discovered that the lipid-soluble thiamine derivative benfotiamine can inhibit these three pathways, as well as hyperglycemia-associated NF-kappaB activation, by activating the pentose phosphate pathway enzyme transketolase, which converts glyceraldehyde-3-phosphate and fructose-6-phosphate into pentose-5-phosphates and other sugars.
Thiamine deficiency and malaria in adults from southeast Asia.
White et al., Bangkok, Thailand. In Lancet, 1999
The activation coefficient for transketolase activity in erythrocytes was used to measure thiamine deficiency.
The effect of acetaldehyde on human brain transketolase activity.
Pratt et al., London, United Kingdom. In Addict Biol, 1997
In the present investigation the direct effect of ACH was studied on the activity of transketolase, a thiaminedependent enzyme, as well as two non-thiamine-dependent enzymes (aspartate aminotransferase and lactate dehydrogenase), isolated from five control human brains.
Pathway engineering for the production of aromatic compounds in Escherichia coli.
Valle et al., Ecatepec, Mexico. In Nat Biotechnol, 1996
This increased carbon commitment to the aromatic pathway was enhanced still further upon amplification of the E. coli tktA gene that encodes for a transketolase involved in the biosynthesis of E4P.
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