gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 May 2015.


This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, CK7, V1a
Papers on transketolase
The coupling of glycolysis and the Rubisco-based pathway through the non-oxidative pentose phosphate pathway to achieve low carbon dioxide emission fermentation.
Li et al., T'ai-chung-shih, Taiwan. In Bioresour Technol, 31 Jul 2015
The first is achieved by elevating the expression of transketolase I (TktA) and the second by blocking the native oxidation-decarboxylation reaction of E. coli by deleting the zwf gene from the chromosome (designated as JB/pTA and MZB, respectively).
High-throughput sequencing reveals adaptation-induced mutations in pentose-fermenting strains of Zymomonas mobilis.
Rao et al., Urbana, United States. In Biotechnol Bioeng, 05 Jun 2015
We also found that increased transketolase activity and reduced glyceraldehyde-3-phosphate dehydrogenase activity improve arabinose fermentations in Z. mobilis.
Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation.
Oehler et al., Adelaide, Australia. In Clin Exp Metastasis, 21 May 2015
Our proteomic studies investigating the interactions between peritoneal (LP-9) and ovarian cancer (OVCAR-5) cells found transketolase (TKT) to be regulated in the co-culture system.
[Limiting metabolic steps in the utilization of D-xylose by recombinant Ralstonia eutropha W50-EAB].
Weng et al., In Wei Sheng Wu Xue Bao, Mar 2015
METHODS: The transketolase (tktA, cbbT2) and transaldolase (tal) gene were cloned from R. eutropha chromosome by PCR and inserted into expressing vector pBBR1MCS-3.
Paraptosis cell death induction by the thiamine analog benfotiamine in leukemia cells.
Nakao et al., Kanazawa, Japan. In Plos One, Dec 2014
Benfotiamine is a synthetic thiamine analogue that stimulates transketolase, a cellular enzyme essential for glucose metabolism.
Structure and functioning mechanism of transketolase.
Solovjeva et al., Moscow, Russia. In Biochim Biophys Acta, Sep 2014
Transketolase, discovered independently by Racker and Horecker in 1953 (and named by Racker) [1], did not receive much attention until 1992, when crystal X-ray structure analysis of the enzyme from Saccharomyces cerevisiae was performed [2].
Engineering stereoselectivity of ThDP-dependent enzymes.
Pohl et al., London, United Kingdom. In Febs J, 2013
Both structurally different enzyme families differ also in stereoselectivity: enzymes from the decarboxylase family are predominantly R-selective, whereas those from the transketolase family are S-selective.
Using site-saturation mutagenesis to explore mechanism and substrate specificity in thiamin diphosphate-dependent enzymes.
McLeish et al., Indianapolis, United States. In Febs J, 2013
We also summarize the results obtained when SSM was used to evolve new substrate specificity and/or enantioselectivity in ThDP-dependent enzymes such as benzoylformate decarboxylase, transketolase, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase and the E1 component of the 2-oxoglutarate dehydrogenase complex.
[Vitamin B1 (thiamine)].
Guilland, Dijon, France. In Rev Prat, 2013
The biological exploration of vitamin B1 status is based on the measurement of thiamine pyrophosphate concentration or of the activity of a thiamine-dependent enzyme, transketolase, in erythrocytes.
Sub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate.
Tittmann et al., Göttingen, Germany. In Nat Chem, 2013
Here, we report sub-ångström-resolution crystal structures of genuine covalent reaction intermediates of transketolase.
The role of thiamine in cancer: possible genetic and cellular signaling mechanisms.
Nguyễn et al., Westminster, United States. In Cancer Genomics Proteomics, 2013
Genetic studies have helped identify a number of factors that link thiamine to cancer, including the solute carrier transporter (SLC19) gene, transketolase, transcription factor p53, poly(ADP-ribose) polymerase-1 gene, and the reduced form of nicotinamide adenine dinucleotide phosphate.
Antihypertensive role of tissue kallikrein in hyperaldosteronism in the mouse.
Bouby et al., Paris, France. In Endocrinology, 2012
The study suggests that kallikrein plays an antihypertensive role in hyperaldosteronism.
Characterization of non-oxidative transaldolase and transketolase enzymes in the pentose phosphate pathway with regard to xylose utilization by recombinant Saccharomyces cerevisiae.
Yano et al., Hiroshima, Japan. In Enzyme Microb Technol, 2012
characterization of NQM1 and TKL2, together with TAL1 and TKL1, regarding their roles in xylose utilization and fermentation
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Yaspo et al., Berlin, Germany. In J Biol Chem, 2011
TKT is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
Riboneogenesis in yeast.
Caudy et al., Princeton, United States. In Cell, 2011
Riboneogenesis begins with synthesis, by the combined action of transketolase and aldolase, of the seven-carbon bisphosphorylated sugar sedoheptulose-1,7-bisphosphate.
Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy.
Kanková et al., Brno, Czech Republic. In Nephrol Dial Transplant, 2011
Single Nucleotide Polymorphism in transketolase is associated with diabetic nephropathy.
The crystal structure of human transketolase and new insights into its mode of action.
Tittmann et al., Halle, Germany. In J Biol Chem, 2010
The crystal structure of human transketolase and new insights into its mode of action.
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.
Brownlee et al., Mannheim, Germany. In Nat Med, 2003
We have discovered that the lipid-soluble thiamine derivative benfotiamine can inhibit these three pathways, as well as hyperglycemia-associated NF-kappaB activation, by activating the pentose phosphate pathway enzyme transketolase, which converts glyceraldehyde-3-phosphate and fructose-6-phosphate into pentose-5-phosphates and other sugars.
Thiamine deficiency and malaria in adults from southeast Asia.
White et al., Bangkok, Thailand. In Lancet, 1999
The activation coefficient for transketolase activity in erythrocytes was used to measure thiamine deficiency.
Pathway engineering for the production of aromatic compounds in Escherichia coli.
Valle et al., Ecatepec, Mexico. In Nat Biotechnol, 1996
This increased carbon commitment to the aromatic pathway was enhanced still further upon amplification of the E. coli tktA gene that encodes for a transketolase involved in the biosynthesis of E4P.
share on facebooktweetadd +1mail to friends