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This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, CK7, fibrillin-1
Papers on transketolase
Oral cancer cells may rewire alternative metabolic pathways to survive from siRNA silencing of metabolic enzymes.
Hu et al., In Bmc Cancer, 25 Apr 2014
METHODS: UM1 and UM2 oral cancer cells were transfected with siRNA to transketolase (TKT) or siRNA to adenylate kinase (AK2), and Western blotting was used to confirm the knockdown.
On the role of GAPDH isoenzymes during pentose fermentation in engineered Saccharomyces cerevisiae.
Oreb et al., Frankfurt am Main, Germany. In Fems Yeast Res, 24 Feb 2014
D-glyceraldehyde-3-phosphate, a glycolytic intermediate, is a substrate of GAPDH but is also utilized by transaldolase and transketolase in the scrambling reactions of the non-oxidative pentose phosphate pathway.
Engineering stereoselectivity of ThDP-dependent enzymes.
Pohl et al., London, United Kingdom. In Febs J, Dec 2013
Both structurally different enzyme families differ also in stereoselectivity: enzymes from the decarboxylase family are predominantly R-selective, whereas those from the transketolase family are S-selective.
Using site-saturation mutagenesis to explore mechanism and substrate specificity in thiamin diphosphate-dependent enzymes.
McLeish et al., Indianapolis, United States. In Febs J, Dec 2013
We also summarize the results obtained when SSM was used to evolve new substrate specificity and/or enantioselectivity in ThDP-dependent enzymes such as benzoylformate decarboxylase, transketolase, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase and the E1 component of the 2-oxoglutarate dehydrogenase complex.
Metabolic flux responses to genetic modification for shikimic acid production by Bacillus subtilis strains.
Liu et al., Beijing, China. In Microb Cell Fact, Dec 2013
Experiments on genetic deletion of phosphoenoylpyruvate kinase gene confirmed its positive influence on SA production, while the overexpression of the transketolase gene did not lead to increase in SA production.
[Vitamin B1 (thiamine)].
Guilland, Dijon, France. In Rev Prat, Oct 2013
The biological exploration of vitamin B1 status is based on the measurement of thiamine pyrophosphate concentration or of the activity of a thiamine-dependent enzyme, transketolase, in erythrocytes.
Sub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate.
Tittmann et al., Göttingen, Germany. In Nat Chem, Sep 2013
Here, we report sub-ångström-resolution crystal structures of genuine covalent reaction intermediates of transketolase.
The role of thiamine in cancer: possible genetic and cellular signaling mechanisms.
Nguyễn et al., Westminster, United States. In Cancer Genomics Proteomics, Jul 2013
Genetic studies have helped identify a number of factors that link thiamine to cancer, including the solute carrier transporter (SLC19) gene, transketolase, transcription factor p53, poly(ADP-ribose) polymerase-1 gene, and the reduced form of nicotinamide adenine dinucleotide phosphate.
Current options and perspectives in the treatment of diabetic neuropathy.
Kempler et al., Szeged, Hungary. In Curr Pharm Des, 2012
The mode of action of benfotiamine is based on inhibition of key alternative pathways, including the polyol, hexosamine, protein-kinase-C pathways, and inhibition of advanced glycation end products formation, just as on activation of transketolase.
Antihypertensive role of tissue kallikrein in hyperaldosteronism in the mouse.
Bouby et al., Paris, France. In Endocrinology, 2012
The study suggests that kallikrein plays an antihypertensive role in hyperaldosteronism.
Characterization of non-oxidative transaldolase and transketolase enzymes in the pentose phosphate pathway with regard to xylose utilization by recombinant Saccharomyces cerevisiae.
Yano et al., Hiroshima, Japan. In Enzyme Microb Technol, 2012
characterization of NQM1 and TKL2, together with TAL1 and TKL1, regarding their roles in xylose utilization and fermentation
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Yaspo et al., Berlin, Germany. In J Biol Chem, 2011
TKT is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
Riboneogenesis in yeast.
Caudy et al., Princeton, United States. In Cell, 2011
Riboneogenesis begins with synthesis, by the combined action of transketolase and aldolase, of the seven-carbon bisphosphorylated sugar sedoheptulose-1,7-bisphosphate.
Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy.
Kanková et al., Brno, Czech Republic. In Nephrol Dial Transplant, 2011
Single Nucleotide Polymorphism in transketolase is associated with diabetic nephropathy.
The crystal structure of human transketolase and new insights into its mode of action.
Tittmann et al., Halle, Germany. In J Biol Chem, 2010
The crystal structure of human transketolase and new insights into its mode of action.
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.
Brownlee et al., Mannheim, Germany. In Nat Med, 2003
We have discovered that the lipid-soluble thiamine derivative benfotiamine can inhibit these three pathways, as well as hyperglycemia-associated NF-kappaB activation, by activating the pentose phosphate pathway enzyme transketolase, which converts glyceraldehyde-3-phosphate and fructose-6-phosphate into pentose-5-phosphates and other sugars.
Thiamine deficiency and malaria in adults from southeast Asia.
White et al., Bangkok, Thailand. In Lancet, 1999
The activation coefficient for transketolase activity in erythrocytes was used to measure thiamine deficiency.
Pathway engineering for the production of aromatic compounds in Escherichia coli.
Valle et al., Ecatepec, Mexico. In Nat Biotechnol, 1996
This increased carbon commitment to the aromatic pathway was enhanced still further upon amplification of the E. coli tktA gene that encodes for a transketolase involved in the biosynthesis of E4P.
Plastid development in primary leaves of Phaseolus vulgaris : The effects of D-threo and L-threo chloramphenicol on the light-induced formation of enzymes of the photosynthetic carbon pathway.
Bradbeer et al., London, United Kingdom. In Planta, 1971
tructosediphosphate aldolase (EC and transketolase (EC,
[Enzyme formation in rye seedlings during the change from heterotrophic to autotrophic growth].
Feierabend, Göttingen, Germany. In Planta, 1966
Ribulose diphosphate carboxylase and transketolase are absent in dry seeds; ribose phosphate isomerase is found only in trace amounts.
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