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Transglutaminase 1

Transglutaminase, transglutaminase 1, LII, TGM1
The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: tissue transglutaminase, CAN, ACID, HAD, V1a
Papers on Transglutaminase
Transglutaminase is a tumor cell and cancer stem cell survival factor.
Kerr et al., Baltimore, United States. In Mol Carcinog, Oct 2015
Recent studies indicate that cancer cells express elevated levels of type II transglutaminase (TG2), and that expression is further highly enriched in cancer stem cells derived from these cancers.
[Transglutaminase and neurodegenerative diseases].
Wang et al., Changsha, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, Aug 2015
Transglutaminase (TG) is a kind of calcium-dependent enzymes.
Physiological, pathological, and structural implications of non-enzymatic protein-protein interactions of the multifunctional human transglutaminase 2.
Fésüs et al., Debrecen, Hungary. In Cell Mol Life Sci, Aug 2015
Transglutaminase 2 (TG2) is a ubiquitously expressed member of an enzyme family catalyzing Ca(2+)-dependent transamidation of proteins.
Update on autosomal recessive congenital ichthyosis: mRNA analysis using hair samples is a powerful tool for genetic diagnosis.
Akiyama et al., Nagoya, Japan. In J Dermatol Sci, Jul 2015
Three major ARCI phenotypes are harlequin ichthyosis (HI), lamellar ichthyosis (LI), and congenital ichthyosiform erythroderma (CIE).
Effect of Fish Sarcoplasmic Protein on Quality Attributes of No-fat Chicken Sausages Mediated by Microbial Transglutaminase.
Chin et al., Nong Khai, Thailand. In Korean J Food Sci Anim Resour, 2014
Fish sarcoplasmic protein (SP) obtaining from lyophilization was evaluated its effect on the qualities of the no-fat chicken sausages in the presence of microbial transglutaminase (MTG) as compared to sodium tripolyphosphate (STPP).
Evaluation of Acid-treated Fish Sarcoplasmic Proteins on Physicochemical and Rheological Characteristics of Pork Myofibrillar Protein Gel Mediated by Microbial Transglutaminase.
Chin et al., Khon Kaen, Thailand. In Korean J Food Sci Anim Resour, 2014
Because of the high recovery yield and water absorption capacity, AFSP was selected to incorporate into MP with/without microbial transglutaminase (MTG).
Transglutaminase regulation of cell function.
Mehta et al., In Physiol Rev, 2014
Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding functions that participate in regulation of cell fate in a wide range of cellular systems and are implicated to have roles in development of disease.
Effects of pH-treated Fish Sarcoplasmic Proteins on the Functional Properties of Chicken Myofibrillar Protein Gel Mediated by Microbial Transglutaminase.
Chin et al., Nong Khai, Thailand. In Korean J Food Sci Anim Resour, 2013
The objective of this study was to evaluate the addition of fish sarcoplasmic protein (SP) solution, which was adjusted to pH 3.0 or 12.0, neutralized to pH 7.0, and lyophilized to obtain the acid- and alkaline-treated SP samples, on the functional properties of the chicken myofibrillar protein induced by microbial transglutaminase (MTG).
Effects of pH-Shift Processing and Microbial Transglutaminase on the Gel and Emulsion Characteristics of Porcine Myofibrillar System.
Choi et al., Cheju, South Korea. In Korean J Food Sci Anim Resour, 2013
This study investigated the effects of microbial transglutaminase (MTGase) and pH-shift processing on the functional properties of porcine myofibrillar proteins (MP).
Beyond the Intestinal Celiac Mucosa: Diagnostic Role of Anti-TG2 Deposits, a Systematic Review.
Catassi et al., Ancona, Italy. In Front Med (lausanne), 2013
AIM: To review the existing literature on the role and significance of intestinal transglutaminase 2 immunoglobulin A deposits (TG2 deposits) in patients with overt celiac disease (CD), potential celiac disease (PCD), and other autoimmune or gluten-related conditions.
Effect of NaCl, Gum Arabic and Microbial Transglutaminase on the Gel and Emulsion Characteristics of Porcine Myofibrillar Proteins.
Hong et al., Seoul, South Korea. In Korean J Food Sci Anim Resour, 2013
This study investigated the effect of gum arabic (GA) combined with microbial transglutaminase (TG) on the functional properties of porcine myofibrillar protein (MP).
Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation.
Ratan et al., White Plains, United States. In J Neurosci, 2012
Forced expression of TG1 or TG2 proteins is sufficient to induce neuronal death in Rattus norvegicus cortical neurons in vitro.
Vena cava and aortic smooth muscle cells express transglutaminases 1 and 4 in addition to transglutaminase 2.
Watts et al., East Lansing, United States. In Am J Physiol Heart Circ Physiol, 2012
These studies demonstrate that tranglutaminase 2 independent activity exists in the vasculature and that Tgm1 and tgm4 are expressed in vascular tissues
Characterization of TGM1 c.984+1G>A mutation identified in a homozygous carrier of lamellar ichthyosis.
Vega et al., Santiago de Compostela, Spain. In Int J Dermatol, 2012
Our splicing assay, together with bioinformatic prediction tools, supports the pathological effect of the recently identified c.984+1G>A mutation in the TGM1 gene and unravels the molecular mechanism by which c.984+1G>A acts.
Knocking-in the R142C mutation in transglutaminase 1 disrupts the stratum corneum barrier and postnatal survival of mice.
Yamanishi et al., Nishinomiya, Japan. In J Dermatol Sci, 2012
The R142C mutation of transglutaminase 1 reduces the enzyme stability which is indispensable for development of the stratum corneum and skin barrier function and for postnatal survival of mice.
[Novel compound heterozygous mutations of TGM1 gene identified in a Chinese collodion baby].
Wang et al., Guangzhou, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
TGM1 genotypes of the family were used to determine parental origins of the mutations.
A homolog of Drosophila grainy head is essential for epidermal integrity in mice.
Jane et al., Melbourne, Australia. In Science, 2005
We report that formation and maintenance of the epidermal barrier in mice are dependent on a mammalian homolog of grainy head, Grainy head-like 3. Mice lacking this factor display defective skin barrier function and deficient wound repair, accompanied by reduced expression of transglutaminase 1, the key enzyme involved in cross-linking the structural components of the superficial epidermis.
Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine.
Steinman et al., Stanford, United States. In Nat Med, 2002
Transglutaminase (TGase) may be critical in the pathogenesis, via cross-linking huntingtin.
Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease.
Sollid et al., Oslo, Norway. In Nat Med, 1998
The action of tissue Transglutaminase (TGase) on specific protein-bound glutamine residues plays a critical role in numerous biological processes.
Corrective gene transfer in the human skin disorder lamellar ichthyosis.
Khavari et al., Palo Alto, United States. In Nat Med, 1996
LI has been associated with loss of keratinocyte transglutaminase 1 (TGase1), an enzyme believed necessary for normal formation of the cornified epidermal barrier.
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