Transglutaminase inhibitors: a patent review.
Ottawa, Canada. In Expert Opin Ther Pat, Dec 2015
Areas covered: This review presents an overview of TGase inhibitors published in the patent literature, from the first compounds developed in the late 1980's, to the current date.
Transglutaminase regulation of cell function.
In Physiol Rev, 2014
Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding functions that participate in regulation of cell fate in a wide range of cellular systems and are implicated to have roles in development of disease.
A homolog of Drosophila grainy head is essential for epidermal integrity in mice.
Melbourne, Australia. In Science, 2005
We report that formation and maintenance of the epidermal barrier in mice are dependent on a mammalian homolog of grainy head, Grainy head-like 3. Mice lacking this factor display defective skin barrier function and deficient wound repair, accompanied by reduced expression of transglutaminase 1, the key enzyme involved in cross-linking the structural components of the superficial epidermis.