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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 May 2015.

Transferrin

Transferrin
This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: HAD, CAN, Serum albumin, ACID, transferrin receptor
Papers using Transferrin antibodies
Receptor-mediated endocytosis involves tyrosine phosphorylation of cortactin
Supplier
Oro Anthony E. et al., In The Journal of Cell Biology, 2006
... Endocytosis was measured using HRP-conjugated mouse Transferrin (Tfn; Sigma-Aldrich) and detected using a Sensolyte ADHP HRP ELISA Assay kit (AnaSpec).
Pseudomonas lipopolysaccharide accelerates wound repair via activation of a novel epithelial cell signaling cascade.
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Signoret Nathalie, In PLoS ONE, 2005
... Manassas, VA) were grown as a monolayer in DMEM media supplemented with 5% FBS (Hyclone), 0.1% Insulin-Transferrin-Selenium (ITS) and 1% Penicillin/Streptomycin (BD Biosciences, San Jose, CA), in ...
Dynamics of protein binding to telomeres in living cells: implications for telomere structure and function
Supplier
Ouellette Michel M. et al., In Nucleic Acids Research, 2003
... Fetal bovine serum, Transferrin and Microcystin-LR were from HyClone (Logan, UT, USA), Collaborative Biomedical Products (Bedford, MA, USA) ...
Compartmentalization of integrin α6β4 signaling in lipid rafts
Supplier
Giancotti Filippo G. et al., In The Journal of Cell Biology, 1997
... Src SRC2, anti-caveolin-1 N-20, and anti-β4 C-20 and N-20), Transduction Laboratories (anti-Yes mAb), Zymed Laboratories (anti-Transferrin mAb), BD Biosciences (anti-tubulin mAb), CHEMICON International ...
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
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Chang Yung-Fu, In PLoS ONE, 1994
... mix (1∶1) supplemented with 5% Fetal Bovine Serum, 5 ng/ml Epidermal Growth Factor (Sigma-Aldrich) and 5 ng/ml Insulin-Transferrin-Selenium mixture (BD Biosciences) without antibiotics at 37°C ...
Papers on Transferrin
CD71 in Gestational Pathology: A Versatile Immunohistochemical Marker With New Possible Applications.
New
Manfrin et al., Verona, Italy. In Appl Immunohistochem Mol Morphol, 21 May 2015
UNASSIGNED: Transferrin receptor/CD71 is a membrane protein expressed on nucleated red blood cells (NRBCs) and trophoblasts.
2D-DIGE proteomic analysis identifies new potential therapeutic targets for adrenocortical carcinoma.
New
Luconi et al., Florence, Italy. In Oncotarget, 20 Apr 2015
The differential expression was validated by Western blot for Aldehyde-dehydrogenase-6-A1,Transferrin, Fascin-1,Lamin A/C,Adenylate-cyclase-associated-protein-1 and Ferredoxin-reductase.
Transferrin and thyroid hormone converge in the control of myelinogenesis.
New
Pasquini et al., Buenos Aires, Argentina. In Exp Neurol, Mar 2015
We have also demonstrated that Tf mRNA exhibited a seven-fold increase in hyperthyroid animals.
Iron regulatory protein 1 suppresses hypoxia-induced iron uptake proteins expression and decreases iron levels in HepG2 cells.
New
Zhu et al., Nantong, China. In J Cell Biochem, Mar 2015
UNASSIGNED: Transferrin receptor (TfR1) and divalent metal transporter 1 (DMT1) are important proteins for cellular iron uptake, and both are regulated transcriptionally through the binding of hypoxia-inducible factor 1 (HIF-1) to hypoxia-responsive elements (HREs) under hypoxic conditions.
Prevalence of alpha thalassemia in microcytic anemia: a tertiary care experience from north India.
New
Saxena et al., New Delhi, India. In Mediterr J Hematol Infect Dis, Dec 2014
They had either low or normal Transferrin Saturation (TS).
Hypobaric hypoxia-mediated protein expression in plasma of susceptible & tolerant rats.
New
Aggarwal et al., New Delhi, India. In Indian J Med Res, Dec 2014
NADB-Rossmann superfamily (Rab GDP dissociation inhibitor β) and Transferrin superfamily (two Serotransferrins), having potential role in imparting tolerance against hypoxia.
High fat diet subverts hepatocellular iron uptake determining dysmetabolic iron overload.
New
Valenti et al., Milano, Italy. In Plos One, Dec 2014
HFD was associated with increased expression of the major iron uptake protein Transferrin receptor-1 (TfR-1), consistently with upregulation of the intracellular iron sensor Iron regulated protein-1 (IRP1).
Catecholamines Promote Actinobacillus pleuropneumoniae Growth by Regulating Iron Metabolism.
New
Zhou et al., Wuhan, China. In Plos One, Dec 2014
Transferrin, one of the components in serum, inhibited the growth of A. pleuropneumoniae in CDM, an effect reversed by addition of catecholamines in a TonB2-dependent manner.
Molecular dynamics simulations of iron- and aluminum-loaded serum transferrin: protonation of Tyr188 is necessary to prompt metal release.
GeneRIF
Lopez et al., San Sebastián, Spain. In Biochemistry, 2012
The study demonstrates for the first time that the protonation of Tyr188 is required for the release of metal from iron- and aluminum-loaded serum transferrin.
The immunobiology of apotransferrin in type 1 diabetes.
GeneRIF
Nicoletti et al., Catania, Italy. In Clin Exp Immunol, 2012
Patients with newly diagnosed type 1 diabetes have lower apoTf serum levels than healthy controls & patients with long-lasting disease. apoTf has a pivotal role in the perpetuation of type 1 diabetes pathology.
Involvement of multiple distinct Bordetella receptor proteins in the utilization of iron liberated from transferrin by host catecholamine stress hormones.
GeneRIF
Suhadolc et al., Minneapolis, United States. In Mol Microbiol, 2012
BfrA, BfrD and BfrE are catecholamine receptors and are involved in the utilization of iron liberated from transferrin by host catecholamine stress hormones.
Transferrin as a model system for method development to study structure, dynamics and interactions of metalloproteins using mass spectrometry.
Review
Gumerov et al., Amherst Center, United States. In Biochim Biophys Acta, 2012
BACKGROUND: Transferrin (Tf) is a paradigmatic metalloprotein, which has been extensively studied in the past and still is a focal point of numerous investigation efforts owing to its unique role in iron homeostasis and enormous promise as a component of a wide range of therapies.
The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice.
GeneRIF
Watanabe et al., Nara, Japan. In Plos One, 2011
These results indicate that CALM is required for erythroid maturation and transferrin internalization in mice.
ApoTransferrin: dual role on adult subventricular zone-derived neurospheres.
GeneRIF
Pasquini et al., Buenos Aires, Argentina. In Plos One, 2011
This evidence supports a key role of Tf on the generation of oligodendrocytes (OLs) from Neural stem and progenitor cells (NSC/NPCs)and highlights its potential in demyelinating disorder treatment.
The impact of mass spectrometry in the diagnosis of congenital disorders of glycosylation.
Review
Garozzo et al., Catania, Italy. In J Inherit Metab Dis, 2011
Electrospray (ESI) MS and matrix assisted laser desorption ionization (MALDI) MS are effective for underglycosylation analyses of intact serum Transferrin (Tf) in CDG-I patients by mass determination of individual component glycoforms.
Expression and function of iron-regulatory proteins in retina.
Review
Ganapathy et al., Augusta, United States. In Iubmb Life, 2010
Hemochromatosis, a genetic disorder of iron overload, is caused by mutations in at least five genes, namely HFE, hemojuvelin, Transferrin receptor 2, ferroportin, and hepcidin.
Hemochromatosis and Vibrio vulnificus wound infections.
Review
Acton et al., Birmingham, United States. In J Clin Gastroenterol, 2009
Transferrin saturation was 89% and serum ferritin was 4761 pmol/L.
[CDT: a biological marker of alcohol abuse].
Review
Ferrario et al., Varese, Italy. In Med Lav, 2007
CONCLUSIONS: CDT (Carbohydrate-Deficient-Transferrin) meets all these requirements and offers the physician a significant tool as a marker of chronic alcohol abuse.
SPECIES AND GEOGRAPHIC DIFFERENCES IN THE TRANSFERRIN POLYMORPHISM OF MACAQUES.
Impact
REKLYS et al., In Science, 1965
Eleven molecular forms and 34 phenotypes of transferrin have been detected in 372 serums from six macaque species.
TRANSFERRIN: VARIATIONS IN BLOOD SERUM OF RED HOWLER MONKEYS.
Impact
ARENDS et al., In Science, 1964
Three different phenotypes were found and denominated A, B, and C. Four serums could not be classified because their transferrin apparently did not bind iron-59, possibly owing to saturation.
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