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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 12 Nov 2015.


This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: HAD, CAN, Serum albumin, ACID, AGE
Papers using Transferrin antibodies
Receptor-mediated endocytosis involves tyrosine phosphorylation of cortactin
Oro Anthony E. et al., In The Journal of Cell Biology, 2006
... Endocytosis was measured using HRP-conjugated mouse Transferrin (Tfn; Sigma-Aldrich) and detected using a Sensolyte ADHP HRP ELISA Assay kit (AnaSpec).
Pseudomonas lipopolysaccharide accelerates wound repair via activation of a novel epithelial cell signaling cascade.
Signoret Nathalie, In PLoS ONE, 2005
... Manassas, VA) were grown as a monolayer in DMEM media supplemented with 5% FBS (Hyclone), 0.1% Insulin-Transferrin-Selenium (ITS) and 1% Penicillin/Streptomycin (BD Biosciences, San Jose, CA), in ...
Dynamics of protein binding to telomeres in living cells: implications for telomere structure and function
Ouellette Michel M. et al., In Nucleic Acids Research, 2003
... Fetal bovine serum, Transferrin and Microcystin-LR were from HyClone (Logan, UT, USA), Collaborative Biomedical Products (Bedford, MA, USA) ...
Compartmentalization of integrin α6β4 signaling in lipid rafts
Giancotti Filippo G. et al., In The Journal of Cell Biology, 1997
... Src SRC2, anti-caveolin-1 N-20, and anti-β4 C-20 and N-20), Transduction Laboratories (anti-Yes mAb), Zymed Laboratories (anti-Transferrin mAb), BD Biosciences (anti-tubulin mAb), CHEMICON International ...
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Chang Yung-Fu, In PLoS ONE, 1994
... mix (1∶1) supplemented with 5% Fetal Bovine Serum, 5 ng/ml Epidermal Growth Factor (Sigma-Aldrich) and 5 ng/ml Insulin-Transferrin-Selenium mixture (BD Biosciences) without antibiotics at 37°C ...
Papers on Transferrin
Transferrin Sialylation in Smoking and Non-Smoking Pregnant Women with Intrauterine Growth Restriction.
Milnerowicz et al., Wrocław, Poland. In Fetal Pediatr Pathol, 15 Nov 2015
UNASSIGNED: Transferrin (Tf) is a glycosylated protein responsible for transporting iron.
The missing link in EBV immune evasion: the BDLF3 gene induces ubiquitination and downregulation of MHC class I and MHC class II.
Rowe et al., Birmingham, United Kingdom. In J Virol, 14 Nov 2015
We report that BDLF3 down-regulates expression of surface MHC class I and class II molecules in the absence of any effect upon other surface molecules screened, including CD54 (ICAM-1) and CD71 (Transferrin receptor).
Transferrin Receptor 1 in Chronic Hypoxia-Induced Pulmonary Vascular Remodeling.
Masuyama et al., Nishinomiya, Japan. In Am J Hypertens, 29 Oct 2015
Transferrin receptor 1 (TfR1) plays a key role in cellular iron transport.
Response of plasma copper, ceruloplasmin, iron and ions in carp, Cyprinus carpio to waterborne copper ion and nanoparticles exposure.
Hoseinifar et al., Gorgān, Iran. In Comp Biochem Physiol C Toxicol Pharmacol, 23 Oct 2015
Transferrin saturation (TSA) ratio showed significant increase in CuSO4 (3rd and 7th days) and high concentration nano-Cu (7th day) treatments.
A comparative study of myocardial molecular phenotypes of two tfr2β null mice: Role in ischemia/reperfusion.
Roetto et al., Torino, Italy. In Biofactors, 10 Oct 2015
Transferrin receptor 2 (Tfr2) is an iron-modulator transcribed in two isoforms, Tfr2α and Tfr2β.
Hepcidin levels in children with chronic liver disease.
Demir et al., Trabzon, Turkey. In Saudi J Gastroenterol, Sep 2015
Transferrin saturation and hepcidin:ferritin ratio were significantly low in patients with severe fibrosis compared with patients with mild/without fibrosis (15.5 ± 5.5 vs 34.3 ± 30.1, P = 0.017 and 1 ± 0.5 vs 1.9 ± 1.4,P = 0.04, respectively).
Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease.
Hébert et al., Québec, Canada. In Mol Ther Nucleic Acids, Dec 2014
Proteomics analysis identified a number of additional putative miR-16 targets in vivo, including α-Synuclein and Transferrin receptor 1. Top-ranking biological networks associated with miR-16 delivery included AD and oxidative stress.
Second Trimester Anaemia in Pregnant Ghanaians.
Segbefia et al., Accra, Ghana. In West Afr J Med, Oct 2014
Transferrin saturation was low in 39 subjects; 24 of these also had low serum iron, which was suggestive of iron deficiency.
Molecular dynamics simulations of iron- and aluminum-loaded serum transferrin: protonation of Tyr188 is necessary to prompt metal release.
Lopez et al., San Sebastián, Spain. In Biochemistry, 2012
The study demonstrates for the first time that the protonation of Tyr188 is required for the release of metal from iron- and aluminum-loaded serum transferrin.
The immunobiology of apotransferrin in type 1 diabetes.
Nicoletti et al., Catania, Italy. In Clin Exp Immunol, 2012
Patients with newly diagnosed type 1 diabetes have lower apoTf serum levels than healthy controls & patients with long-lasting disease. apoTf has a pivotal role in the perpetuation of type 1 diabetes pathology.
Involvement of multiple distinct Bordetella receptor proteins in the utilization of iron liberated from transferrin by host catecholamine stress hormones.
Suhadolc et al., Minneapolis, United States. In Mol Microbiol, 2012
BfrA, BfrD and BfrE are catecholamine receptors and are involved in the utilization of iron liberated from transferrin by host catecholamine stress hormones.
Transferrin as a model system for method development to study structure, dynamics and interactions of metalloproteins using mass spectrometry.
Gumerov et al., Amherst Center, United States. In Biochim Biophys Acta, 2012
BACKGROUND: Transferrin (Tf) is a paradigmatic metalloprotein, which has been extensively studied in the past and still is a focal point of numerous investigation efforts owing to its unique role in iron homeostasis and enormous promise as a component of a wide range of therapies.
The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice.
Watanabe et al., Nara, Japan. In Plos One, 2011
These results indicate that CALM is required for erythroid maturation and transferrin internalization in mice.
ApoTransferrin: dual role on adult subventricular zone-derived neurospheres.
Pasquini et al., Buenos Aires, Argentina. In Plos One, 2011
This evidence supports a key role of Tf on the generation of oligodendrocytes (OLs) from Neural stem and progenitor cells (NSC/NPCs)and highlights its potential in demyelinating disorder treatment.
The impact of mass spectrometry in the diagnosis of congenital disorders of glycosylation.
Garozzo et al., Catania, Italy. In J Inherit Metab Dis, 2011
Electrospray (ESI) MS and matrix assisted laser desorption ionization (MALDI) MS are effective for underglycosylation analyses of intact serum Transferrin (Tf) in CDG-I patients by mass determination of individual component glycoforms.
Expression and function of iron-regulatory proteins in retina.
Ganapathy et al., Augusta, United States. In Iubmb Life, 2010
Hemochromatosis, a genetic disorder of iron overload, is caused by mutations in at least five genes, namely HFE, hemojuvelin, Transferrin receptor 2, ferroportin, and hepcidin.
Hemochromatosis and Vibrio vulnificus wound infections.
Acton et al., Birmingham, United States. In J Clin Gastroenterol, 2009
Transferrin saturation was 89% and serum ferritin was 4761 pmol/L.
[CDT: a biological marker of alcohol abuse].
Ferrario et al., Varese, Italy. In Med Lav, 2007
CONCLUSIONS: CDT (Carbohydrate-Deficient-Transferrin) meets all these requirements and offers the physician a significant tool as a marker of chronic alcohol abuse.
REKLYS et al., In Science, 1965
Eleven molecular forms and 34 phenotypes of transferrin have been detected in 372 serums from six macaque species.
ARENDS et al., In Science, 1964
Three different phenotypes were found and denominated A, B, and C. Four serums could not be classified because their transferrin apparently did not bind iron-59, possibly owing to saturation.
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