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GTF3A general transcription factor IIIA

transcription factor IIIA
The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, POLYMERASE, Histone, V1a
Papers on transcription factor IIIA
Small ubiquitin-like modifier (SUMO)-mediated repression of the Xenopus Oocyte 5 S rRNA genes.
Huber et al., Nanuque, Brazil. In J Biol Chem, 2015
The 5 S rRNA gene-specific transcription factor IIIA (TFIIIA) interacts with the small ubiquitin-like modifier (SUMO) E3 ligase PIAS2b and with one of its targets, the transcriptional corepressor, XCtBP.
5S rRNA and accompanying proteins in gonads: powerful markers to identify sex and reproductive endocrine disruption in fish.
Cancio et al., Bilbao, Spain. In Environ Sci Technol, 2012
In anuran ovaries, 5S rDNA is regulated transcriptionally by transcription factor IIIA (TFIIIA), which upon transcription, binds 5S rRNA, forming 7S RNP.
Transcript levels, alternative splicing and proteolytic cleavage of TFIIIA control 5S rRNA accumulation during Arabidopsis thaliana development.
Tourmente et al., Clermont-Ferrand, France. In Plant J, 2012
5S ribosomal RNA, an essential component of the large ribosomal subunit, is transcribed by RNA polymerase III and specifically requires transcription factor IIIA (TFIIIA).
Binding site for Xenopus ribosomal protein L5 and accompanying structural changes in 5S rRNA.
Huber et al., United States. In Biochemistry, 2011
While the former is unique to L5, the latter is also a critical contact site for transcription factor IIIA (TFIIIA), accounting for the mutually exclusive binding of these two proteins to 5S RNA.
Ribosomal protein L5 and transcription factor IIIA from Arabidopsis thaliana bind in vitro specifically Potato spindle tuber viroid RNA.
Daròs et al., Valencia, Spain. In Arch Virol, 2011
The ribosomal protein L5 and transcription factor IIIA (TFIIIA) from Arabidopsis thaliana bind 5S rRNA in vitro and in vivo, mediating different functions that include nucleocytoplasmic transport and transcription activation, respectively.
Visualizing protein interactions involved in the formation of the 42S RNP storage particle of Xenopus oocytes.
Scheer et al., Würzburg, Germany. In Biol Cell, 2010
The tRNA-binding protein 42Sp50 belongs to the EF1A (eukaryotic translation elongation factor 1A) family of translation elongation factors, while 42Sp43 is a diverged form of the transcription factor TFIIIA (transcription factor IIIA) and binds 5S rRNA.
The discovery of zinc fingers and their development for practical applications in gene regulation and genome manipulation.
Klug, Cambridge, United Kingdom. In Q Rev Biophys, 2010
Zinc fingers were discovered in 1985, arising from the interpretation of our biochemical studies on the interaction of the Xenopus protein transcription factor IIIA (TFIIIA) with 5S RNA.
The discovery of zinc fingers and their applications in gene regulation and genome manipulation.
Klug, Cambridge, United Kingdom. In Annu Rev Biochem, 2009
An account is given of the discovery of the classical Cys(2)His(2) zinc finger, arising from the interpretation of biochemical studies on the interaction of the Xenopus protein transcription factor IIIA with 5S RNA, and of structural studies on its structure and its interaction with DNA.
Multiple modes of RNA recognition by zinc finger proteins.
Hall, United States. In Curr Opin Struct Biol, 2005
Recent structural studies of the C(2)H(2) zinc fingers of transcription factor IIIA (TFIIIA) and the CCCH zinc fingers of Tis11d in complex with their RNA targets have revealed new modes of zinc finger interaction with nucleic acid.
Xenopus transcription factor IIIA and the 5S nucleosome: development of a useful in vitro system.
Hayes et al., Rochester, United States. In Biochem Cell Biol, 2003
Moreover, the structure of the primary factor initiating transcription of 5S DNA, transcription factor IIIA, has been extensively characterized.
Adult-onset primary open-angle glaucoma caused by mutations in optineurin.
Sarfarazi et al., Farmington, United States. In Science, 2002
The OPTN gene codes for a conserved 66-kilodalton protein of unknown function that has been implicated in the tumor necrosis factor-alpha signaling pathway and that interacts with diverse proteins including Huntingtin, Ras-associated protein RAB8, and transcription factor IIIA. Optineurin is expressed in trabecular meshwork, nonpigmented ciliary epithelium, retina, and brain, and we speculate that it plays a neuroprotective role.
Disruption of the zinc finger domain: a common target that underlies many of the effects of lead.
Razmiafshari et al., Kingston, United States. In Neurotoxicology, 2000
More recently, the effects of Pb on the DNA-binding of the zinc finger protein transcription factor IIIA (TFIIIA) have been demonstrated.
Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.
Pabo et al., Cambridge, United States. In Science, 1993
Zinc finger proteins, of the type first discovered in transcription factor IIIA (TFIIIA), are one of the largest and most important families of DNA-binding proteins.
EXAFS study of the zinc-binding sites in the protein transcription factor IIIA.
Klug et al., In Nature, 1987
The protein transcription factor IIIA (TFIIIA) is involved in the synthesis of 5S RNA in vitro by RNA polymerase III.
The crystal structure of d(GGATGGGAG): an essential part of the binding site for transcription factor IIIA.
Kennard et al., In Nature, 1986
One such protein, transcription factor IIIA (TFIIIA) from the frog, activates the gene for 5S RNA by binding to the region of the gene between nucleotides 45 and 97.
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