transcription factor IIIA
Multiple modes of RNA recognition by zinc finger proteins.
United States. In Curr Opin Struct Biol, 2005
Recent structural studies of the C(2)H(2) zinc fingers of transcription factor IIIA (TFIIIA) and the CCCH zinc fingers of Tis11d in complex with their RNA targets have revealed new modes of zinc finger interaction with nucleic acid.
Adult-onset primary open-angle glaucoma caused by mutations in optineurin.
Farmington, United States. In Science, 2002
The OPTN gene codes for a conserved 66-kilodalton protein of unknown function that has been implicated in the tumor necrosis factor-alpha signaling pathway and that interacts with diverse proteins including Huntingtin, Ras-associated protein RAB8, and transcription factor IIIA. Optineurin is expressed in trabecular meshwork, nonpigmented ciliary epithelium, retina, and brain, and we speculate that it plays a neuroprotective role.