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Ets variant 7

transcription factor Ets-1, TEL2, transcription factor Ets-2
The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721).[provided by RefSeq, May 2011] (from NCBI)
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Top mentioned proteins: NET, CAN, V1a, Ets-2, MMP-9
Papers on transcription factor Ets-1
Transcription factor Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in rodent models.
New
Han et al., Nanjing, China. In Diabetologia, Feb 2016
AIMS/HYPOTHESIS: 'Glucotoxicity' is a term used to convey the negative effect of hyperglycaemia on beta cell function; however, the underlying molecular mechanisms that impair insulin secretion and gene expression are poorly defined.
Synthetic Bax-Anti Bcl2 combination module actuated by super artificial hTERT promoter selectively inhibits malignant phenotypes of bladder cancer.
New
Huang et al., Shenzhen, China. In J Exp Clin Cancer Res, Dec 2015
RESULTS: We demonstrated that the artificial hTERT promoter had a higher driven efficiency which might be regulated by transcription factor ETS-1 in bladder cancer cells, compared with wild-type hTERT promoter.
TEL2 suppresses metastasis by down-regulating SERPINE1 in nasopharyngeal carcinoma.
New
Kang et al., Guangzhou, China. In Oncotarget, Nov 2015
Here, using our customized gene microarray containing all of the known human transcription factors and the current markers for epithelial-mesenchymal transition, we report that TEL2 was down-regulated in highly metastatic NPC cells and the metastatic tissues in lymph node.
Fentanyl inhibits the invasion and migration of colorectal cancer cells via inhibiting the negative regulation of Ets-1 on BANCR.
New
Ma et al., Kaifeng, China. In Biochem Biophys Res Commun, Oct 2015
Since studies indicates the abnormal expression of transcription factor Ets-1 and BRAF-activated lncRNA (BANCR) in CRC progress, the relationship between Ets-1 and BANCR was investigated here to illustrate the fentanyl-induced mechanism on CRC in vitro.
Binding Rate Constants Reveal Distinct Features of Disordered Protein Domains.
New
Jemth et al., Uppsala, Sweden. In Biochemistry, Sep 2015
We have performed an extensive characterization of the ionic strength dependence of the interaction between the molten globular nuclear co-activator binding domain (NCBD) of CREB binding protein and five different protein ligands, including the intrinsically disordered activation domain of p160 transcriptional co-activators (SRC1, TIF2, ACTR), the p53 transactivation domain, and the folded pointed domain (PNT) of transcription factor ETS-2. Direct comparisons of the binding rate constants under identical conditions show that the association rate constant, kon, for interactions between NCBD and disordered protein domains is high at low salt concentrations (90-350 × 10(6) M(-1) s(-1) at 4 °C) but is reduced significantly (10-30-fold) with an increasing ionic strength and reaches a plateau around physiological ionic strength.
Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2.
New
Gileadi et al., Oxford, United Kingdom. In J Biol Chem, Apr 2015
Ets-2, like its closely related homologue Ets-1, is a member of the Ets family of DNA binding transcription factors.
Ets-1 as an early response gene against hypoxia-induced apoptosis in pancreatic β-cells.
Han et al., Nanjing, China. In Cell Death Dis, 2014
In this study, we identified the transcription factor Ets-1 (v-ets erythroblastosis virus E26 oncogene homolog 1) as an early response gene against hypoxia-induced apoptosis in pancreatic β-cells.
Transcriptome analysis of complex I-deficient patients reveals distinct expression programs for subunits and assembly factors of the oxidative phosphorylation system.
Vogel et al., Nijmegen, Netherlands. In Bmc Genomics, 2014
Analysis of evolutionarily conserved transcription factor binding sites in the promoters of these genes revealed almost all known OXPHOS regulators (including GABP, NRF1/2, SP1, YY1, E-box factors) and a set of novel candidates (ELK1, KLF7, SP4, EHF, ZNF143, and TEL2).
Oxidative stress and Down syndrome. Do antioxidants play a role in therapy?
Review
Ďuračková et al., Bratislava, Slovakia. In Physiol Res, 2013
Trisomy 21 in patients with DS results in increased activity of an important antioxidant enzyme Cu/Zn superoxide dismutase (SOD) which gene is located on the 21st chromosome along with other proteins such as transcription factor Ets-2, stress inducing factors (DSCR1) and precursor of beta-amyloid protein responsible for the formation of amyloid plaques in Alzheimer disease.
A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer.
O'Connor et al., Dublin, Ireland. In Breast Cancer Res, 2013
This regulation is dependent on the DNA-binding transcription factor ETS-1 which recruits EMSY and the histone demethylase KDM5B to the miR-31 promoter, thus repressing its transcription.
Saccharomyces cerevisiae Tel2 plays roles in TORC signaling and telomere maintenance that can be mutationally separated.
GeneRIF
Siede et al., Fort Worth, United States. In Biochem Biophys Res Commun, 2012
these findings demonstrate separation of function explainable by differential binding of Tel2 to its PIKK substrates Tel1 or Tor1/Tor2 and thus a critical contribution of Tel2 to the interface that links various PIKKs to this chaperone complex.
Genetic and physical interactions between Tel2 and the Med15 Mediator subunit in Saccharomyces cerevisiae.
GeneRIF
Charbonneau et al., Lyon, France. In Plos One, 2011
Existence of a novel role for Tel2, namely in transcription, possibly in cooperation with Rvb2 and involving the existence of physical interactions with the Med15/Gal11 Mediator subunit.
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.
GeneRIF
Boulton et al., London, United Kingdom. In Mol Cell, 2010
The CK2 phospho-dependent interaction between TEL2 and the R2TP complex affects phosphatidylinositol 3-kinase-related kinase functions and is essential for mTOR and SMG1 stability in vivo.
Transcription factor Ets-1 in cytokine and chemokine gene regulation.
Review
Garrett-Sinha et al., Buffalo, United States. In Cytokine, 2010
Ets-1 is a transcription factor that is highly expressed within lymphoid cells, where it is known to control their differentiation, survival and proliferation.
Mechanisms associated with mitochondrial-generated reactive oxygen species in cancer.
Review
Singh et al., Hamilton, Canada. In Can J Physiol Pharmacol, 2010
Increased ROS production by defective cancer cell mitochondria also results in the upregulation of the transcription factor Ets-1, a factor that has been increasingly associated with aggressive cancers.
Mec1 function in the DNA damage response does not require its interaction with Tel2.
GeneRIF
Blackburn et al., San Francisco, United States. In Cell Cycle, 2008
Tel2 can specifically and differentially regulate the function of individual PIKKs.
The transcription factor ETS-1: its role in tumour development and strategies for its inhibition.
Review
Wernert et al., Bonn, Germany. In Mini Rev Med Chem, 2008
Transcription factors are an important group of proteins.
Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.
GeneRIF
Blackburn et al., San Francisco, United States. In Genes Dev, 2008
Data show that Tel1 and Tel2 interact, and that even when Tel1 protein levels are high, this interaction is specifically required for Tel1 localization to a DNA break and its activation of downstream targets.
The transcription factor Ets-1 in breast cancer.
Review
Bove et al., Albany, United States. In Front Biosci, 2005
The proto-oncogene Ets-1 is a member of the Ets family of transcription factors which share a unique DNA binding domain, the Ets domain.
Modulation of transcription factor Ets-1 DNA binding: DNA-induced unfolding of an alpha helix.
Impact
Graves et al., Salt Lake City, United States. In Science, 1995
Here, studies of the transcription factor Ets-1 provided evidence that local protein unfolding also can accompany DNA binding.
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