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Transcobalamin II

transcobalamin II, Tc2, TC II
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: HAD, Cbl, ACID, CAN, AGE
Papers on transcobalamin II
The effects of citrus extract (Citrox(©)) on the naturally occurring microflora and inoculated pathogens, Bacillus cereus and Salmonella enterica, in a model food system and the traditional Greek yogurt-based salad Tzatziki.
New
Savvaidis et al., Ioánnina, Greece. In Food Microbiol, Feb 2016
Of the two treatments, TC2 yielded the lowest yeast counts, irrespective of temperature, resulting in approximately 2 (4 °C) and 3 (10 °C) log reductions on the final day of storage (70 and 30 days, respectively).
s-triazine degrading bacterial isolate Arthrobacter sp. AK-YN10, a candidate for bioaugmentation of atrazine contaminated soil.
New
Kapley et al., Nāgpur, India. In Appl Microbiol Biotechnol, Jan 2016
Draft genome sequencing revealed similarity to pAO1, TC1, and TC2 catabolic plasmids of the Arthrobacter taxon.
Trypanosoma cruzi III causing the indeterminate form of Chagas disease in a semi-arid region of Brazil.
New
da Câmara et al., Natal, Brazil. In Int J Infect Dis, Oct 2015
TcI and TcII were also detected, in 37.5% (6/16) and 43.8% (7/16) of patients, respectively.
Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)(+) TH2/TH1 cell imbalance, whereas adults acquire CLA(+) TH22/TC22 cell subsets.
New
Guttman-Yassky et al., Tel Aviv-Yafo, Israel. In J Allergy Clin Immunol, Oct 2015
METHODS: Flow cytometry was used to measure CD69/inducible costimulator/HLA-DR frequency in memory cell subsets, as well as IFN-γ, IL-13, IL-9, IL-17, and IL-22 cytokines, defining TH1/cytotoxic T (TC) 1, TH2/TC2, TH9/TC9, TH17/TC17, and TH22/TC22 populations in CD4 and CD8 cells, respectively.
The 3 major types of innate and adaptive cell-mediated effector immunity.
Review
New
Romagnani et al., Florence, Italy. In J Allergy Clin Immunol, Mar 2015
Type 2 immunity consists of GATA-3(+) ILC2s, TC2 cells, and TH2 cells producing IL-4, IL-5, and IL-13, which induce mast cell, basophil, and eosinophil activation, as well as IgE antibody production, thus protecting against helminthes and venoms.
[Microinvasive dental treatment in pre-school children].
Korolenkova, Moscow, Russia. In Stomatologiia (mosk), 2014
Wireless dental endo motor (Endo Mate TC2, NSK, Japan) was used for cavity preparation.
[Information analytical support of the US Armed Forces Medical Service at the theater of operations (review of foreign online publications)].
Review
Kuvakin et al., In Voen Med Zh, 2013
The main TMIP subprograms are introduced, namely: AHLTA, TMDS, MSAT, TMIP-M, MMM, TC2, NCAT, and the basic providing and supporting unit DHIMS is described.
How prevalent is vitamin B(12) deficiency among vegetarians?
Review
Lucus et al., Greenville, United States. In Nutr Rev, 2013
Using a PubMed search to identify relevant publications, 18 articles were found that reported B12 deficiency rates from studies that identified deficiency by measuring methylmalonic acid, holo-transcobalamin II, or both.
Polymorphisms in transcobalamin II gene is associated with coronary artery disease in Indian population.
GeneRIF
Sengupta et al., Delhi, India. In Biomarkers, 2012
Three SNPs in transcobalamin II gene (G1196A, C776G and C1043T) are significantly associated with coronary artery disease in Indian population.
Transcobalamin 2 variant associated with poststroke homocysteine modifies recurrent stroke risk.
GeneRIF
Sale et al., Winston-Salem, United States. In Neurology, 2011
Variation in the TCN2 gene also affects recurrent stroke risk in response to cofactor therapy
Transcobalamin polymorphism 67A->G, but not 776C->G, affects serum holotranscobalamin in a cohort of healthy middle-aged men and women.
GeneRIF
Ueland et al., Bergen, Norway. In J Nutr, 2011
genetic association studies in adult populations in Norway: Serum holoTC concentration (but not other indicators of cobalamin status) is lower in TCN2 67AG or 67GG than in 67AA but did not differ among TCN2 776C>G genotypes.
Maternal one-carbon metabolism, MTHFR and TCN2 genotypes and neural tube defects in India.
GeneRIF
Yajnik et al., Pune, India. In Birth Defects Res A Clin Mol Teratol, 2011
Maternal 776C>G polymorphism in TCN2 was strongly predictive of NTD in the offspring (p = 0.006).
A single nucleotide polymorphism in transcobalamin II (I5V) induces structural changes in the protein as revealed by molecular modeling studies.
GeneRIF
Sengupta et al., New Delhi, India. In Biochemistry, 2011
structural change of TCII induced by single nucleotide polymorphism
Vitamin B12-mediated transport: a potential tool for tumor targeting of antineoplastic drugs and imaging agents.
Review
Jain et al., Sāgar, India. In Crit Rev Ther Drug Carrier Syst, 2007
The uptake of vitamin B12 (cyanocobalamin, Cbl/VB12) in mammalian cells is mediated by specific, high-affinity receptors for the vitamin B12-binding protein, transcobalamin II, which is expressed on the plasma membrane.
Diagnosis of megaloblastic anaemias.
Review
Wickramasinghe, London, United Kingdom. In Blood Rev, 2006
Other useful investigations include serum/plasma methylmalonic acid (MMA), plasma total homocysteine (tHCYS) and serum holo-transcobalamin II assays.
Molecular classification of multiple myeloma: a distinct transcriptional profile characterizes patients expressing CCND1 and negative for 14q32 translocations.
Impact
Neri et al., Milano, Italy. In J Clin Oncol, 2005
RESULTS: Class-prediction analysis identified 112 probe sets as characterizing the TC1, TC2, TC4 and TC5 groups, whereas the TC3 samples showed heterogeneous phenotypes and no marker genes.
Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines.
Impact
Mosmann et al., Edmonton, Canada. In Immunity, 1995
We propose the names TC1 and TC2 for cytotoxic CD8+ T cells secreting Th1-like and Th2-like cytokines, respectively.
R-binder deficiency. A clinically benign cause of cobalamin pseudodeficiency.
Impact
Carmel, In Jama, 1983
His level of serum cobalamin, however, which was carried largely by transcobalamin II, was not as decreased as in the initial cases reported and was higher by some assays than by others.
Receptor binding and internalization of immobilized transcobalamin II by mouse leukaemia cells.
Impact
Jacobsen et al., In Nature, 1981
Membrane transport of vitamin B12 (cyanocobalamin; Cbl) into mammalian cells is mediated by the serum protein transcobalamin II (TCII).
Problems with the serum vitamin B12 assay.
Impact
Linnell et al., In Lancet, 1980
The metabolically important serum binder is transcobalamin II and deficiency of this protein causes a potentially lethal megaloblastic anaemia even though the serum cobalamin level is normal.
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