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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Trafficking protein, kinesin binding 1

Trak1, OIP106, Trafficking protein, kinesin-binding 1, KIAA1042
Top mentioned proteins: GRIF-1, V1a, Arht1, ACID, Rdl
Papers on Trak1
DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites.
Kittler et al., London, United Kingdom. In J Biol Chem, Feb 2016
Here we have demonstrated that DISC1 couples to the mitochondrial transport and fusion machinery via interaction with the outer mitochondrial membrane GTPase proteins Miro1 and Miro2, the TRAK1 and TRAK2 mitochondrial trafficking adaptors, and the mitochondrial fusion proteins (mitofusins).
Localization of the kinesin adaptor proteins trafficking kinesin proteins 1 and 2 in primary cultures of hippocampal pyramidal and cortical neurons.
Stephenson et al., London, United Kingdom. In J Neurosci Res, Jul 2015
Previous work has established that trafficking kinesin proteins (TRAKs),TRAK1 and TRAK2, are kinesin adaptor proteins that link mitochondria to kinesin motor proteins via an acceptor protein in the mitochondrial outer membrane, etc. the Rho GTPase Miro.
Acupuncture improves locomotor function by enhancing GABA receptor expression in transient focal cerebral ischemia rats.
Liu et al., Beijing, China. In Neurosci Lett, Mar 2015
After acupuncture, the expressions of the two receptors were increased, but levels of GABA and trafficking protein, kinesin binding 1 (TRAK1), which plays a role in the intracellular transport of GABA receptors, were unchanged.
Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individuals.
Carlberg et al., Kuopio, Finland. In Mol Nutr Food Res, 2014
Taking the genes DUSP10, TRAK1, NRIP1, and THBD as examples, we confirmed the predicted VDR binding sites upstream of their transcription start sites and showed rapid mRNA up-regulation of all four genes in SGBS human pre-adipocytes.
Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons.
Chesselet et al., Los Angeles, United States. In Neurobiol Dis, 2014
Prdx1, Prdx2, Glrx2, Hspa9, Pink1, Drp1, Trak1) and dopamine-related (Th, Ddc, Gch1, Dat, Vmat2, Drd2, Chnr6a) genes.
Revisiting the TRAK family of proteins as mediators of GABAA receptor trafficking.
Stephenson, London, United Kingdom. In Neurochem Res, 2014
A pivotal role for TRAK1 and TRAK2 in the transport of mitochondria is well recognized.
DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking.
Millar et al., Edinburgh, United Kingdom. In Hum Mol Genet, 2014
Disrupted-In-Schizophrenia 1 (DISC1) is a candidate risk factor for schizophrenia, bipolar disorder and severe recurrent depression.
Delineation of the TRAK binding regions of the kinesin-1 motor proteins.
Stephenson et al., London, United Kingdom. In Febs Lett, 2013
To refine the TRAK1/2 binding sites within the kinesin-1 cargo domain, rationally designed C-terminal truncations of KIF5A and KIF5C were generated and their co-association with TRAK1/2 determined by quantitative co-immunoprecipitations following co-expression in mammalian cells.
Mitochondrial trafficking in neurons.
Schwarz, Boston, United States. In Cold Spring Harb Perspect Biol, 2013
In addition to kinesin and dynein, this complex contains the proteins Miro (also called RhoT1/2) and milton (also called TRAK1/2) and is responsible for much, although not necessarily all, mitochondrial movement.
TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites.
Hoogenraad et al., Utrecht, Netherlands. In Neuron, 2013
Here, we show that TRAK family adaptor proteins, TRAK1 and TRAK2, which link mitochondria to microtubule-based motors, are required for axonal and dendritic mitochondrial motility and utilize different transport machineries to steer mitochondria into axons and dendrites.
Identification and characterization of genes related to the development of breast muscles in Pekin duck.
Hou et al., Beijing, China. In Mol Biol Rep, 2012
The results showed that unknown clone A233, C83 and C99 showed descending tendency as age increased; KBTBD10, HSPA8, MYL1, ZFP622, MARCH4, Nexilin, FABP4 and MUSTN1 had high expression levels at 6 weeks old; WAC, NT5C3, HSP90AA1, MRPL33, KLF6, TSNAX, CDC42EP3, HSPA4, TRAK1, NR2F2, HAUS1 and IGF1 had high expression levels at 8 weeks and showed ascending tendency as age increased.
Genome-wide transcript expression analysis in the uterovaginal junction in association with fertile period in Tsaiya ducks.
Hsu et al., Taiwan. In J Reprod Dev, 2011
In contrast, trafficking kinesin-binding protein 1 (TRAK1), the expression of which was increased by 2.33-fold in the long-period group as compared with its counterparts, has been suggested to inhibit precocious activation of sperm and prolong sperm life in the female sperm reservoir.
Elevated expression of MGb2-Ag/TRAK1 is correlated with poor prognosis in patients with colorectal cancer.
Zhao et al., Xi'an, China. In Int J Colorectal Dis, 2011
MGb2-Ag/TRAK1 may play an important role in the development of colorectal cancer (CRC) and may be a valuable prognostic indicator of CRC.
Tumor-specific usage of alternative transcription start sites in colorectal cancer identified by genome-wide exon array analysis.
Andersen et al., Ã…rhus, Denmark. In Bmc Genomics, 2010
RESULTS: By profiling 108 colorectal samples using exon arrays, we identified nine genes (TCF12, OSBPL1A, TRAK1, ANK3, CHEK1, UGP2, LMO7, ACSL5, and SCIN) showing tumor-specific alternative TSS usage in both adenoma and cancer samples relative to normal mucosa.
Pathological feature of a giant ileal Meckel's diverticulum with ectopic gastric mucosa.
Zhang et al., Nanjing, China. In Clin J Gastroenterol, 2010
The pathological features of the mucosa were evaluated by investigation for Helicobacter pylori; and the nuclear proliferation antigen Ki-67, the gastrointestinal cancer-associated biomarker TRAK1, synaptophysin, and neurofilament were used to precisely define the mucosa and neuronal and ganglion cell components.
Identification of TRAK1 (Trafficking protein, kinesin-binding 1) as MGb2-Ag: a novel cancer biomarker.
Fan et al., Xi'an, China. In Cancer Lett, 2009
TRAK1/MGb2-Ag is a promising diagnostic marker for gastric cancer and may help to detect signet-ring cell carcinoma and mucinous adenocarcinoma
Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking.
Chin et al., Atlanta, United States. In J Mol Biol, 2008
Data show that Trak1 interacts with hepatocyte-growth-factor-regulated tyrosine kinase substrate (Hrs), an essential component of the endosomal sorting and trafficking machinery.
Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice.
Lahn et al., Chicago, United States. In Nat Genet, 2006
Our data implicate Trak1 as a crucial regulator of GABA(A) receptor homeostasis and underscore the importance of hyrt mice as a model for studying the molecular etiology of hypertonia associated with human neurological diseases.
GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin.
Stephenson et al., London, United Kingdom. In J Biol Chem, 2005
GRIF-1 and OIP106 have roles in protein and/or organelle transport in excitable cells in a manner analogous to glutamate receptor-interacting-protein 1
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