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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

TNF receptor-associated factor 7

Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004] (from NCBI)
Top mentioned proteins: merlin, KLF4, Smo, Ubiquitin, AP-1
Papers on TRAF7
Mutational landscape of MCPyV-positive and MCPyV-negative merkel cell carcinomas with implications for immunotherapy.
Choi et al., New Haven, United States. In Oncotarget, Jan 2016
We show that MCPyV-negative MCCs have a high mutation burden (median of 1121 somatic single nucleotide variants (SSNVs) per-exome with frequent mutations in RB1 and TP53 and additional damaging mutations in genes in the chromatin modification (ASXL1, MLL2, and MLL3), JNK (MAP3K1 and TRAF7), and DNA-damage pathways (ATM, MSH2, and BRCA1).
Genetic/molecular alterations of meningiomas and the signaling pathways targeted.
Tabernero et al., Coimbra, Portugal. In Oncotarget, Jun 2015
Thus, monosomy 22, which is often associated with mutations of the NF2 gene, has emerged as the most frequent alteration of meningiomas; in addition, several other genes (e.g., AKT1, KLF4, TRAF7, SMO) and chromosomes have been found to be recurrently altered often in association with more complex karyotypes and involvement of multiple signaling pathways.
Genome-wide DNA methylation modified by soy phytoestrogens: role for epigenetic therapeutics in prostate cancer?
Bernard-Gallon et al., Clermont-Ferrand, France. In Omics, Apr 2015
In addition, the methylation frequencies of the MAD1L1, TRAF7, KDM4B, and hTERT genes were remarkably modified by genistein treatment.
MicroRNA-126 attenuates palmitate-induced apoptosis by targeting TRAF7 in HUVECs.
Zhu et al., Hefei, China. In Mol Cell Biochem, 2015
The induction of miR-126 correlated with a reduction in TRAF7.
Biology and clinical management challenges in meningioma.
Preusser et al., Magdeburg, Germany. In Am Soc Clin Oncol Educ Book, 2014
Rare genetic events in benign meningiomas are mutations in TRAF7, KLF4, AKT1, and SMO; all of these mutations are exclusive of NF2 alterations.
Molecular genetics of meningiomas: Building the roadmap towards personalized therapy.
Kalamarides et al., Paris, France. In Neurochirurgie, 2014
Recent genome-wide genotyping and exome sequencing studies have confirmed the pivotal role of NF2 in meningioma tumorigenesis, concerning roughly half of the tumors, and unraveled new mutations in non-NF2 meningiomas concerning AKT1, SMO, KLF4 and TRAF7.
UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131.
Chung et al., Seoul, South Korea. In J Biol Chem, 2013
Several SUMO E3 ligases such as topoisomerase I binding, arginine/serine-rich (TOPORS), TNF receptor-associated factor 7 (TRAF7), and tripartite motif containing 27 (TRIM27) have dual functions as ubiquitin E3 ligases.
Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO.
Günel et al., New Haven, United States. In Science, 2013
We report genomic analysis of 300 meningiomas, the most common primary brain tumors, leading to the discovery of mutations in TRAF7, a proapoptotic E3 ubiquitin ligase, in nearly one-fourth of all meningiomas.
Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations.
von Deimling et al., Heidelberg, Germany. In Acta Neuropathol, 2013
All secretory meningiomas invariably harbored a mutation in both KLF4 and TRAF7.
Downregulation of ubiquitin E3 ligase TNF receptor-associated factor 7 leads to stabilization of p53 in breast cancer.
Liu et al., Beijing, China. In Oncol Rep, 2013
Through search for other possible p53 E3 ligases by mRNA and protein expression analysis, downregulation of TNF receptor-associated factor 7 (TRAF7) expression was found in these breast tumors.
The seventh ring: exploring TRAF7 functions.
Stilo et al., Benevento, Italy. In J Cell Physiol, 2012
TRAF7 is involved in signal transduction pathways that lead either to activation or repression of NF-kappaB transcription factor.
Tumor necrosis factor (TNF) receptor-associated factor 7 is required for TNFα-induced Jun NH2-terminal kinase activation and promotes cell death by regulating polyubiquitination and lysosomal degradation of c-FLIP protein.
Stilo et al., Benevento, Italy. In J Biol Chem, 2012
an important role for TRAF7 in the activation of JNK following TNFalpha stimulation and involvement of this protein in regulating the turnover of c-FLIP
The first homolog of a TRAF7 (TNF receptor-associated factor 7) gene in a mollusk, Crassostrea hongkongensis.
Yu et al., Guangzhou, China. In Fish Shellfish Immunol, 2011
Tumor necrosis factor (TNF) receptor-associated factor 7 (TRAF7) is one of several adaptor proteins that are critically involved in the activation of TLR-dependent NF-κB signaling.
TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation.
Stilo et al., Benevento, Italy. In J Biol Chem, 2011
this study identifies TRAF7 as a NEMO- and p65-interacting molecule and brings important information on the ubiquitination events that control NF-kappaB transcriptional activity.
Traf7, a MyoD1 transcriptional target, regulates nuclear factor-κB activity during myogenesis.
Dynlacht et al., New York City, United States. In Embo Rep, 2010
These results suggest a new mechanism by which MyoD1 function is coupled to NF-kappaB activity through Traf7, regulating the balance between cell cycle progression and differentiation during myogenesis.
Gross genomic rearrangement involving the TSC2-PKD1 contiguous deletion syndrome: characterization of the deletion event by quantitative polymerase chain reaction deletion assay.
Neumann et al., Freiburg, Germany. In Am J Kidney Dis, 2007
Additional analysis showed expansion of the deletion affecting the adjacent downstream-located genes RAB26 and TRAF7, as well as the great majority of CASKIN1.
TRAF7 sequesters c-Myb to the cytoplasm by stimulating its sumoylation.
Ishii et al., Tsukuba, Japan. In Mol Biol Cell, 2005
TRAF7 negatively regulates c-Myb activity by sequestering c-Myb to the cytosol via sumoylation.
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