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TNF receptor-associated factor 4

TRAF4, TNF Receptor-Associated Factor 4, Cart-1
This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, TRAF2, ACID, NF-kappaB, TNF Receptor-Associated Factor 1
Papers using TRAF4 antibodies
Subcellular targeting of oxidants during endothelial cell migration
Supplier
Terada Lance S. et al., In The Journal of Cell Biology, 1999
... Full-length human TRAF4 (Xu et al., 2002) was PCR amplified and subcloned into pDsRed2-N1 or pEGFP-N3 (CLONTECH Laboratories, Inc.) to create ...
Papers on TRAF4
Corticotropin-releasing hormone (CRH) stimulates cocaine- and amphetamine-regulated transcript gene (CART1) expression through CRH type 1 receptor (CRHR1) in chicken anterior pituitary.
New
Li et al., Chengdu, China. In Mol Cell Endocrinol, Jan 2016
Cocaine- and amphetamine-regulated transcript (CART) peptide(s) is generally viewed as neuropeptide(s) and can control food intake in vertebrates, however, our recent study revealed that CART1 peptide is predominantly expressed in chicken anterior pituitary, suggesting that cCART1 peptide is a novel pituitary hormone in chickens and its expression is likely controlled by hypothalamic factor(s).
Appetite regulation in Schizothorax prenanti by three CART genes.
New
Li et al., Chengdu, China. In Gen Comp Endocrinol, Jan 2016
The S. prenanti CART-1, CART-2 and CART-3 full-length cDNA sequences were 597bp, 694bp and 749bp in length, encoding the peptides of 125, 120 and 104 amino acid residues, respectively.
Profile of Inflammation-associated genes during Hepatic Differentiation of Human Pluripotent Stem Cells.
New
Arumugaswami et al., Los Angeles, United States. In Data Brief, Dec 2015
Ligands and receptors of the tumor necrosis factor (TNF) family as well as downstream signaling factors TRAF2, TRAF4, FADD, NFKB1 and NFKBIB were differentially expressed during hepatic differentiation.
Expression, correlation, and prognostic value of TRAF2 and TRAF4 expression in malignant plural effusion cells in human breast cancer.
New
Mi et al., Shenyang, China. In Diagn Cytopathol, Nov 2015
BACKGROUND: TRAF2 and TRAF4, members of the tumor necrosis factor receptor- associated factor family of intracellular signal transduction proteins, are associated with breast cancer progression and metastasis.
A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis.
New
Li et al., Shanghai, China. In J Exp Med, Oct 2015
Here we report a novel IL-17-mediated cascade via the IL-17R-Act1-TRAF4-MEKK3-ERK5 positive circuit that directly stimulates keratinocyte proliferation and tumor formation.
Immunohistochemical and molecular profiling of histologically defined apocrine carcinomas of the breast.
New
Sapino et al., Torino, Italy. In Hum Pathol, Sep 2015
MLPA assay revealed gene copy gains of MYC, CCND1, ZNF703, CDH1, and TRAF4 in 50% or greater of the apocrine carcinomas, whereas gene copy losses frequently affected BRCA2 (75%), ADAM9 (54%), and BRCA1 (46%).
A genome-wide association study identifies multiple loci for variation in human ear morphology.
Ruiz-Linares et al., Puerto Madryn, Argentina. In Nat Commun, 2014
Strongest association in this region is observed for SNP rs17023457 located in an evolutionarily conserved binding site for the transcription factor Cartilage paired-class homeoprotein 1 (CART1), and we confirm that rs17023457 alters in vitro binding of CART1.
Characterization of the Two CART Genes (CART1 and CART2) in Chickens (Gallus gallus).
Wang et al., Chengdu, China. In Plos One, 2014
Cocaine- and amphetamine-regulated transcript (CART) peptide is implicated in the control of avian energy balance, however, the structure and expression of CART gene(s) remains largely unknown in birds.
TRAF4 enhances oral squamous cell carcinoma cell growth, invasion and migration by Wnt-β-catenin signaling pathway.
Cao et al., Xinxiang, China. In Int J Clin Exp Pathol, 2014
Recently, tumor necrosis factor receptor-associated factor 4 (TRAF4) has attracted increasing attenuation due to its overexpression in certain cancers.
TRAF4 mediates activation of TGF-β signaling and is a biomarker for oncogenesis in breast cancer.
Review
Zhang et al., Hangzhou, China. In Sci China Life Sci, 2014
In mammals, there are six distinct members in the tumor-necrosis factor receptor (TNFR)-associated factor (TRAF) family (TRAF1-TRAF6), with the function of TRAF4 not being extensively studied in the past decade.
Cutting edge: TNF receptor-associated factor 4 restricts IL-17-mediated pathology and signaling processes.
GeneRIF
Li et al., Cleveland, United States. In J Immunol, 2012
Primary cells from TRAF4-deficient mice display markedly enhanced IL-17-activated signaling pathways and induction of chemokine mRNA/
IκB kinase α phosphorylation of TRAF4 downregulates innate immune signaling.
GeneRIF
Abbott et al., Cleveland, United States. In Mol Cell Biol, 2012
Like IKKalpha, TRAF4 is atypical within its family because it is the only TRAF family member to negatively regulate innate immune signaling. IKKalpha's phosphorylation of serine-426 on TRAF4 was required for this negative regulation.
Divergent effects of p47(phox) phosphorylation at S303-4 or S379 on tumor necrosis factor-α signaling via TRAF4 and MAPK in endothelial cells.
GeneRIF
Li et al., Guildford, United Kingdom. In Arterioscler Thromb Vasc Biol, 2012
Report divergent effects of p47(phox) phosphorylation at S303-4 or S379 on tumor necrosis factor-alpha signaling via TRAF4 and MAPK in endothelial cells.
Role for Traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes.
GeneRIF
Leptin et al., Köln, Germany. In Mol Cell Biol, 2011
Traf4 is expressed throughout development, and is required for efficient apical constrictions of ventral furrow cells.
In vivo evidence that TRAF4 is required for central nervous system myelin homeostasis.
GeneRIF
Rio et al., Illkirch-Graffenstaden, France. In Plos One, 2011
These results provide conclusive evidence for the pivotal contribution of TRAF4 to myelination.
Insights into prevention of human neural tube defects by folic acid arising from consideration of mouse mutants.
Review
Harris, Vancouver, Canada. In Birth Defects Res A Clin Mol Teratol, 2009
Among responsive mutants, folic acid supplementation reduces exencephaly and/or spina bifida aperta frequency in the Sp(2H), Sp, Cd, Cited2, Cart1, and Gcn5 mutants.
TRAF4, the unique family member.
Review
Rio et al., Illkirch-Graffenstaden, France. In Adv Exp Med Biol, 2006
The fourth member of the TRAF protein family (TRAF4) presents several characteristics that distinguish it from the other members of the family.
Localizing NADPH oxidase-derived ROS.
Review
Ushio-Fukai, Chicago, United States. In Sci Stke, 2006
Targeting of NADPH oxidase to focal complexes in lamellipodia and membrane ruffles through the interaction of p47phox with the scaffold proteins TRAF4 and WAVE1 provides a mechanism for achieving localized ROS production, which is required for directed cell migration.
Antioxidants: the good, the bad and the ugly.
Review
Tardif, Montréal, Canada. In Can J Cardiol, 2006
The nonintervened reference coronary segments of the PCI vessel demonstrated improvements with AGI-1067 in the Canadian Antioxidant Restenosis Trial-1 (CART-1), evidence supportive of a clinical effect on slowing atherosclerosis progression.
Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene.
Impact
de Crombrugghe et al., Houston, United States. In Nat Genet, 1996
The paired-class homeobox-containing gene, Cart1, is expressed in forebrain mesenchyme, branchial arches, limb buds and cartilages during embryogenesis.
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