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TNF receptor-associated factor 2

TRAF2, TNF Receptor-Associated Factor 2, GRP94, gp96, TRA-1
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using TRAF2 antibodies
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis
Leverkus Martin et al., In The Journal of Cell Biology, 2008
... Polyclonal antibodies to HMGB-1 were purchased from Abcam, and TRAF2 (C-20) and CD95 antibodies (C-20) were purchased from Santa Cruz Biotechnology, Inc ...
TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα
Silke John et al., In The Journal of Cell Biology, 2006
... used for Western blots were Goat anti–human IgG HRP (Jackson ImmunoResearch Laboratories), anti-cIAP1 (in house), anti-TRAF2 (Santa Cruz Biotechnology, Inc.), anti-FN14 (Cell Signaling ...
A proteomic screen identified stress-induced chaperone proteins as targets of Akt phosphorylation in mesangial cells.
Cheriyath Venugopalan, In PLoS ONE, 2005
... Anti-GRP94 and Anti-HSP40 antibodies were from Abcam (Cambridge, UK) ...
Human embryonic stem cell lines with genetic disorders
Lavon Neta et al., In In Vitro Cellular & Developmental Biology. Animal, 2004
... As primary antibodies, we used mouse IgG anti-human OCT-3/4, mouse IgM anti-human TRA-1-60 (Santa Cruz Biotechnology Inc, Santa Cruz, CA) ...
Membrane HSP70: the molecule triggering γδ T cells in the early stage of tumorigenesis
Lin Huanping et al., In Clinical and Developmental Immunology, 2004
... HSP72 monoclonal antibody was obtained from StressGen Biotechnologies (Victoria, British Columbia, Canada) and mouse antihuman gp96 monoclonal antibody was purchased from Santa Cruz Biotechnology, Inc (Santa Cruz, CA, ...
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Papers on TRAF2
Human phospholipid scramblase 1 interacts with and regulates transactivation of HTLV-1 Tax.
Eizuru et al., Kagoshima, Japan. In Virology, 2012
PLSCR1 may play an important role in the IFN-mediated repression of Tax-dependent transactivation during HTLV-1 infection.
TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation.
Takeuchi et al., Suita, Japan. In J Biol Chem, 2012
TANK is critical for osteoclastogenesis by regulating NF-kappaB, and is also important for proper bone remodeling.
TNFR-associated factor 2 deficiency in B lymphocytes predisposes to chronic lymphocytic leukemia/small lymphocytic lymphoma in mice.
Zapata et al., Madrid, Spain. In J Immunol, 2012
Expression of endogenous TRAF2 is negligible in Traf2DN-transgenic B cells compared with wild-type mice.
Upregulation of Gp96 correlates with the radiosensitivity and five-year survival rate of nasopharyngeal carcinoma.
Zhang et al., Beijing, China. In Orl J Otorhinolaryngol Relat Spec, 2011
Patients with high Gp96 expression levels were significantly more resistant to radiotherapy in nasopharyngeal carcinoma.
More papers using TRAF2 antibodies
AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation
Molinari Maurizio et al., In The Journal of Cell Biology, 2003
... Antibodies to BiP, EDEM1, and GRP94 were obtained from Santa Cruz Biotechnology, Inc., Sigma-Aldrich, and Thermo ...
Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis
Grimm Stefan et al., In Cell Death and Differentiation, 2002
... Monoclonal antibodies against RIP1, TRAF2 and FADD were purchased from BD Biosciences (UK) ...
Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription
Glimcher Laurie H. et al., In The Journal of Experimental Medicine, 2000
... TRAF2.DN transgenic mice (which overexpress a lymphocyte-specific ...
Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
Vandenberghe Wim et al., In The European Journal of Neuroscience, 1999
... Transduction Laboratories; rabbit anti-Hsp70 was from Stressgen; polyclonal goat anti-DJ-1, rabbit anti-IKKγ (FL-419) and rabbit anti-TRAF2 (C-20) were from Santa Cruz Biotechnology; rabbit anti-BAG5 was from ...
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