Targeting the Wnt signaling pathway in colorectal cancer.
Kōbe, Japan. In Expert Opin Ther Targets, Nov 2015
TRAF2 and NCK-interacting protein kinase (TNIK) was identified as the most downstream regulator of Wnt signaling by two independent research groups, and several classes of small-molecule inhibitors targeting this protein kinase have been developed.
The versatile roles of CARDs in regulating apoptosis, inflammation, and NF-κB signaling.
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Taipei, Taiwan. In Apoptosis, Feb 2015
The CARD subfamily contains 33 human CARD-containing proteins, regulating the assembly of many signaling complexes, including apoptosome, inflammsome, nodosome, the CBM complex, PIDDosome, the TRAF2 complex, and the MAVS signalosome, by homotypic CARD-CARD interactions.