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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

TNFRSF1A-associated via death domain

TRADD
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PrP, NF-kappaB, HSP60, TRAF2, CAN
Papers using TRADD antibodies
Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms
Supplier
Thorburn Andrew et al., In The Journal of Cell Biology, 1999
... Human TRADD sequences encoding a core DD fragment (aa 222–289) and full-length sequences (aa 1–312) of TRADD were subcloned inframe into the COOH-terminal multiple cloning site of the pEGFP-C2 and pEYFP-C1 vectors (CLONTECH Laboratories, Inc.), respectively, to ...
Papers on TRADD
Prognostic significance of CpG island methylator phenotype in surgically resected small cell lung carcinoma.
New
Ishikawa et al., Tokyo, Japan. In Cancer Sci, Feb 2016
Ontology analyses suggested that extrinsic apoptosis pathway was suppressed, including TNFRSF1A, TNFRSF10A and TRADD in CIMP tumors.
Evolutionarily conserved primary TNF sequences relate to its primitive functions in cell death induction.
New
Jiang et al., Xi'an, China. In J Cell Sci, Feb 2016
P16-induced necrosis was mainly through disruption of the cell membrane, whereas P1213-induced apoptosis involved activation of TRADD followed by formation of complex II.
Renal microRNA- and RNA-profiles in progressive chronic kidney disease.
New
Mayer et al., Innsbruck, Austria. In Eur J Clin Invest, Jan 2016
Progressive cases also showed a lower expression of miR-532-3p and an increased expression of target transcripts involved in apoptosis pathways (MAP3K14, TNFRSF10B/TRAIL-R2, TRADD, and TRAF2).
NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis.
New
Impact
Pasparakis et al., Köln, Germany. In Cancer Cell, Dec 2015
Knock-in expression of kinase inactive receptor-interacting protein kinase 1 (RIPK1) prevented hepatocyte apoptosis and HCC, while RIPK1 ablation induced TNFR1-associated death domain protein (TRADD)-dependent hepatocyte apoptosis and liver tumors in NEMO(LPC-KO) mice, revealing distinct kinase-dependent and scaffolding functions of RIPK1.
Effect of curcumin on TNFR2 and TRAF2 in unilateral ureteral obstruction in rats.
New
Abo-El-Matty et al., Bradford, United Kingdom. In Nutrition, Nov 2015
Activation of TNFR1 leads to the recruitment of the adaptor TNFR-associated death domain protein (TRADD), which binds the Ser/Thr kinase receptor-interacting protein (RIP) and TNFR-associated factors 2 (TRAF2).
Poncirus trifoliata Rafin. induces the apoptosis of triple-negative breast cancer cells via activation of the c-Jun NH(2)-terminal kinase and extracellular signal-regulated kinase pathways.
New
Kim et al., Yangsan, South Korea. In Pharmacogn Mag, Oct 2015
In addition, MEPT-induced tumor necrosis factor receptor (TNFR) and TNFR type 1-associated death domain (TRADD) protein and the activations of c-Jun NH(2)-terminal kinase (JNK) and extracellular signal-regulated kinases (ERK).
The Latent Membrane Protein 1 (LMP1).
Review
Sterz et al., München, Germany. In Curr Top Microbiol Immunol, 2014
By acting like a constitutively active receptor, LMP1 recruits cellular signaling molecules associated with tumor necrosis factor receptors such as tumor necrosis factor receptor-associated factor (TRAF) proteins and TRADD to mimic signals of the costimulatory CD40 receptor in the EBV-infected B lymphocyte.
Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains.
Impact
Shao et al., Beijing, China. In Nature, 2013
Death receptor signalling requires death-domain-mediated homotypic/heterotypic interactions between the receptor and its downstream adaptors, including TNFR1-associated death domain protein (TRADD) and FAS-associated death domain protein (FADD).
A type III effector antagonizes death receptor signalling during bacterial gut infection.
Impact
Hartland et al., Melbourne, Australia. In Nature, 2013
Protein interaction studies identified FADD, TRADD and RIPK1 as binding partners of NleB1.
Review: ototoxic characteristics of platinum antitumor drugs.
Review
Salvi et al., Buffalo, United States. In Anat Rec (hoboken), 2012
Combined treatment with ethacrynic acid (a loop diuretic) and cisplatin results in rapid apoptotic hair cell death characterized by upregulation of initiator caspase-8 and membrane death receptor, TRADD, followed by downstream executioners, caspase-3 and caspase-6.
TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation.
Impact
GeneRIF
Mak et al., Toronto, Canada. In Nat Cell Biol, 2012
data indicate that TRADD shuttles dynamically from the cytoplasm into the nucleus to modulate the interaction between p19(Arf) and its E3 ubiquitin ligase ULF, thereby promoting p19(Arf) protein stability and tumour suppression
Ribosomal protein S3 interacts with TRADD to induce apoptosis through caspase dependent JNK activation.
GeneRIF
Kim et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
rpS3 appears to be recruited to the death-inducing signaling complex (DISC) to induce apoptosis by interacting TRADD in response to extracellular stresses.
The role of TRADD in death receptor signaling.
Review
Liu et al., Bethesda, United States. In Cell Cycle, 2012
TRADD (TNFR1-associated death domain protein) was initially identified as an adaptor molecule that transduces the signal downstream of the TNFR1 (tumor necrosis factor receptor 1).
A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma.
GeneRIF
Giordano et al., Philadelphia, United States. In Oncotarget, 2011
NSP 5a3a induces apoptosis in Head and Neck cell line HN30 through p73-DAXX and TRAF2-TRADD.
TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation.
Review
Siegel et al., Bethesda, United States. In Immunol Rev, 2011
DR3 costimulates T-cell activation, but it is unique among these receptors in that it signals through an intracytoplasmic death domain and the adapter protein TRADD (TNFR-associated death domain).
Phospho-SXXE/D motif mediated TNF receptor 1-TRADD death domain complex formation for T cell activation and migration.
GeneRIF
Chin et al., Providence, United States. In J Immunol, 2011
Death domain SXXE/D motifs are phosphorylated, as is required for stable TNFR1-TRADD complex formation and subsequent activation of NF-kappaB in inflamed mucosa.
TRADD is critical for resistance to TRAIL-induced cell death through NF-κB activation.
GeneRIF
Kim et al., Suwŏn, South Korea. In Febs Lett, 2011
Data suggest that deficiency of TRADD sensitizes cells to TRAIL-induced apoptosis, and that enhanced cell death in TRADD(-/-) MEFs is associated with defective NF-kappaB activation.
New developments on the TNFα-mediated signalling pathways.
Review
Melendez et al., Singapore, Singapore. In Biosci Rep, 2011
TNFα induces both survival and apoptotic signal in a TRADD (TNF receptor-associated DD)-dependent and -independent way.
Death receptor signal transducers: nodes of coordination in immune signaling networks.
Review
Impact
Ashkenazi et al., San Francisco, United States. In Nat Immunol, 2009
They transmit signals through apical protein complexes, which are nucleated by the DD adaptors FADD and TRADD, to control cellular outcomes that range from apoptosis to gene activation.
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