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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Potassium channel, subfamily K, member 4

TRAAK, KCNK4
an alkali-sensing two-pore K+ channel [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: TREK-1, TREK-2, ACID, K2P, TASK-3
Papers on TRAAK
Role of leak potassium channels in pain signaling.
Review
New
Toyoda et al., China. In Brain Res Bull, Oct 2015
In this review, we describe evidence for the roles of TASK1, TASK3, TREK1, TREK2, TRAAK and TRESK channels in pain signaling and behavior.
How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.
Review
New
Brohawn, New York City, United States. In Ann N Y Acad Sci, Sep 2015
Here, I review the current understanding of force gating for a family of metazoan mechanosensitive ion channels, the two-pore domain K(+) channels (K2Ps) TRAAK, TREK1, and TREK2.
Insights into the stimulatory mechanism of 2-aminoethoxydiphenyl borate on TREK-2 potassium channel.
New
Ma et al., Guangzhou, China. In Neuroscience, Sep 2015
2-Aminoethoxydiphenyl borate (2-APB) has been recently identified as a common agonist of TWIK-related K(+) channel (TREK)/TRAAK channels, a subfamily of two-pore domain K(+) (K2P) channels.
Racial variation in breast tumor promoter methylation in the Carolina Breast Cancer Study.
New
Swift-Scanlan et al., Chapel Hill, United States. In Cancer Epidemiol Biomarkers Prev, Jun 2015
Genes differentially methylated by race included DSC2, KCNK4, GSTM1, AXL, DNAJC15, HBII-52, TUSC3, and TES; the methylation state of several of these genes may be associated with worse survival in AAs.
Two-pore domain potassium channels: potential therapeutic targets for the treatment of pain.
Review
New
Veale et al., Chatham, United Kingdom. In Pflugers Arch, May 2015
Expression of several different K2P channel subunits has been detected in nociceptive dorsal root ganglion neurons and trigeminal ganglion neurons, in particular, TREK1, TREK2, TRESK, TRAAK, TASK3 and TWIK1 channels.
Differential sensitivity of TREK-1, TREK-2 and TRAAK background potassium channels to the polycationic dye ruthenium red.
New
Czirják et al., Budapest, Hungary. In Br J Pharmacol, Apr 2015
The third member of the TREK subfamily, TRAAK (K2 P 4.1) was more potently inhibited by ruthenium violet, a contaminant in some RR preparations, than by RR.
Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels.
Minor et al., San Francisco, United States. In Neuron, 2015
The TRAAK/TREK K(2P) potassium channel subfamily produces background currents that alter neuronal excitability in response to pressure, temperature, signaling lipids, and anesthetics.
Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Impact
MacKinnon et al., New York City, United States. In Nature, 2015
TRAAK (also known as KCNK4) ion channels are neuronally expressed members of the two-pore domain K(+) (K2P) channel family and are mechanosensitive.
Cold hypersensitivity increases with age in mice with sickle cell disease.
Stucky et al., Milwaukee, United States. In Pain, 2014
These included the transient receptor potential melastatin 8 (Trpm8) and transient receptor potential ankyrin 1 (Trpa1) channels, as well as the 2-pore domain potassium channels, TREK-1 (Kcnk2), TREK-2 (Kcnk10), and TRAAK (Kcnk4).
Enhanced expression of TWIK-related arachidonic acid-activated K+ channel in the spinal cord of detrusor overactivity rats after partial bladder outlet obstruction.
Liang et al., Guangzhou, China. In Bmc Urol, 2014
The objective of this study is to investigate the expression of the TWIK-related arachidonic acid-activated K(+) channel (TRAAK) in the L6-S1 spinal cord of DO rats after PBOO.
Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception.
Noël et al., Clermont-Ferrand, France. In Pain, 2014
The TREK2 channel as well as the related TREK1 and TRAAK channels are mechanical-, thermal- and lipid-gated channels that share many regulatory properties.
Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.
Sandoz et al., Nice, France. In Proc Natl Acad Sci U S A, 2014
One family of lipid-regulated membrane proteins is the TWIK-related K channel (TREK) subfamily of K2P channels: TREK1, TREK2, and TWIK-related arachdonic acid stimulated K(+) channel (TRAAK).
Feeling the hidden mechanical forces in lipid bilayer is an original sense.
Review
Kung et al., Madison, United States. In Proc Natl Acad Sci U S A, 2014
This reductionistic exercise has rigorously been recapitulated recently with two vertebrate mechanosensitive K(+) channels (TREK1 and TRAAK).
Temperature sensitivity of two-pore (K2P) potassium channels.
Review
Bagriantsev et al., New Haven, United States. In Curr Top Membr, 2013
and TRAAK (K2P4.1/KCNK2)
Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel.
Impact
GeneRIF
MacKinnon et al., New York City, United States. In Science, 2012
crystal structure of TRAAK at 3.8 angstroms resolution; channel comprises 2 protomers that create 2-fold symmetric K(+) channel; extracellular surface has a helical cap; 2 diagonally opposed gate-forming inner helices form membrane-interacting structures
Expression of mechanogated two-pore domain potassium channels in mouse lungs: special reference to mechanosensory airway receptors.
GeneRIF
Brouns et al., Antwerp, Belgium. In Histochem Cell Biol, 2011
The TRAAK appears to be strongly involved in regulating airway mechanosensing since it was found to be expressed on the terminals of all subpopulations of potential vagal mechanosensors.
Expression of stretch-activated two-pore potassium channels in human myometrium in pregnancy and labor.
GeneRIF
Tichenor et al., Reno, United States. In Plos One, 2009
role for TREK-1 in contributing to uterine quiescence during gestation
The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception.
GeneRIF
Lazdunski et al., Antibes, France. In Embo J, 2009
Together TREK-1 and TRAAK channels are important regulators of nociceptor activation by cold, particularly in the nociceptor population that is not activated by menthol.
Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells.
GeneRIF
Taniguchi et al., Morioka, Japan. In Neurosci Lett, 2009
present results revealed that TREK-1, TREK-2 and TRAAK channels colocalized with thermosensitive TRP channels in some small trigeminal ganglion neurons
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