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Nuclear receptor subfamily 2, group C, member 1

TR2, TR2-11, orphan nuclear receptor TR2, orphan receptor TR2-11, testicular receptor 2
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, TAK1, V1a, HVEM
Papers using TR2 antibodies
Interrogating androgen receptor function in recurrent prostate cancer
Bevan Charlotte L et al., In Endocrine-Related Cancer, 2002
... LNCaP/TR2 cells were maintained in RPMI medium (Sigma) supplemented with 10% tetracycline-free foetal bovine serum (Clontech) and 12 μg/ml blasticidin (Invitrogen), ...
Papers on TR2
Enhanced retention of drop vertical jump landing technique: A randomized controlled trial.
Otten et al., Groningen, Netherlands. In Hum Mov Sci, Feb 2016
Landing was assessed from a drop vertical jump (DVJ) in five sessions: pretest, two training blocks (TR1 and TR2) and directly after the training sessions (post test) and retention test 1week later.
Testicular receptor 2, Nr2c1, is associated with stem cells in the developing olfactory epithelium and other cranial sensory and skeletal structures.
Maynard et al., Washington, D.C., United States. In Gene Expr Patterns, Jan 2016
UNASSIGNED: Comparative genomic analysis of the nuclear receptor family suggests that the testicular receptor 2, Nr2c1, undergoes positive selection in the human-chimpanzee clade based upon a significant increase in nonsynonymous compared to synonymous substitutions.
Molecular cloning, expression analysis and transcript localization of testicular orphan nuclear receptor 2 in the male catfish, Clarias batrachus.
Senthilkumaran et al., Hyderābād, India. In Gen Comp Endocrinol, Nov 2015
UNASSIGNED: Testicular receptor 2 (TR2; also known as Nr2c1) is one of the first orphan nuclear receptors identified and known to regulate various physiological process with or without any ligand.
RNAi mediated broad-spectrum transgenic resistance in Nicotiana benthamiana to chilli-infecting begomoviruses.
Chakraborty et al., New Delhi, India. In Plant Cell Rep, Aug 2015
For this, we have generated transgenic Nicotiana benthamiana plants harboring two different intron hairpin RNAi constructs [designated as TR1 (AC1/AC2) and TR2 (AC1/AC2/βC1)] using conserved regions of viral genome and associated betasatellite.
Inhibition of DDAH1, but not DDAH2, results in apoptosis of a human trophoblast cell line in response to TRAIL.
Whitley et al., London, United Kingdom. In Hum Reprod, Aug 2015
We further showed that this increased sensitivity to apoptosis is accompanied by a significant increase in the expression of TRAIL receptor 2 (TR2; P < 0.05) but not TRAIL receptor 1 (TR1).
Identification of genetic and environmental factors stimulating excision from Streptomyces scabiei chromosome of the toxicogenic region responsible for pathogenicity.
Beaulieu et al., Sherbrooke, Canada. In Mol Plant Pathol, Aug 2015
An internal att site was also found, suggesting that the TR has a composite structure (TR1 and TR2).
[The effect of blood volume change on the accuracy of pulse contour cardiac output].
Yu et al., Beijing, China. In Zhonghua Wai Ke Za Zhi, Aug 2015
There were statistic differences in SVR at each time point between the two groups (At TR1, t value was -2.810, P < 0.05, at TR2-8, t values were respectively -6.026, -6.026, -5.375, -6.008, -5.406, -5.613 and -5.609, all P < 0.05).
Utilization of solid and liquid waste generated during ethanol fermentation process for production of gaseous fuel through anaerobic digestion--a zero waste approach.
Balasubramanian et al., Vallabh Vidyanagar, India. In Bioresour Technol, Mar 2015
One kg of solid residues (left after enzyme extraction and enzymatic hydrolysis) from thermophilic reactors (TR1 and TR2) produced around 131 and 84L of biogas, respectively, whereas biogas production from mesophilic reactors (MR1 and MR2) was 86 and 62L, respectively.
Release of a Poorly Soluble Drug from Hydrophobically Modified Poly (Acrylic Acid) in Simulated Intestinal Fluids.
Wahlgren et al., Lund, Sweden. In Plos One, 2014
We have previously evaluated the release of hydrophobic drugs from tablets based on Pemulen TR2 and showed that the release can be manipulated by adding surfactants.
Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies.
Engel et al., Sendai, Japan. In Mol Cell Biol, 2014
Multiple reports have now identified several transcription factors that are involved in fetal globin gene repression in definitive (adult)-stage erythroid cells (the TR2/TR4 heterodimer, MYB, KLFs, BCL11A, and SOX6).
Minireview: role of orphan nuclear receptors in cancer and potential as drug targets.
Lee et al., Houston, United States. In Mol Endocrinol, 2014
The nuclear orphan receptors for which endogenous ligands have not been identified include nuclear receptor (NR)0B1 (adrenal hypoplasia congenita critical region on chromosome X gene), NR0B2 (small heterodimer partner), NR1D1/2 (Rev-Erbα/β), NR2C1 (testicular receptor 2), NR2C2 (testicular receptor 4), NR2E1 (tailless), NR2E3 (photoreceptor-specific NR [PNR]), NR2F1 chicken ovalbumin upstream promoter transcription factor 1 (COUP-TFI), NR2F2 (COUP-TFII), NR2F6 (v-erbA-related protein), NR4A1 (Nur77), NR4A2 (Nurr1), NR4A3 (Nor1), and NR6A1 (GCNF).
The role of nuclear receptors in embryonic stem cells.
Cooney et al., Houston, United States. In Adv Exp Med Biol, 2012
LRH1, DAX1, Esrrβ and TR2 play critical roles in maintaining pluripotency, while, GCNF, COUP-TFs and sumoylated TR2 are critical in regulating the exit from pluripotency.
Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes.
Engel et al., Ann Arbor, United States. In Proc Natl Acad Sci U S A, 2011
TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes
Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells.
Tanabe et al., Ann Arbor, United States. In Mol Cell Biol, 2011
in adult erythroid cells, TR2/TR4 bind to the embryonic beta-type globin promoters but not to the adult beta-globin promoter.
Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic development and embryonic stem cells.
Chang et al., Rochester, United States. In Endocrinology, 2009
Possible roles for TR2 and TR4 in early embryonic development by regulating key genes involved in stem cell self-renewal, commitment, and differentiation.
Post-translational modifications of orphan nuclear receptor TR2 - new insights into drug targets for stem cell therapy and the effect of retinoic acid.
Wei, Minneapolis, United States. In Proteomics Clin Appl, 2009
Testicular receptor 2 (TR2) belongs to the nuclear receptor superfamily that constitutes one of the largest transcription factor families.
HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3.
Wei et al., Chandīgarh, India. In Plos One, 2008
This is the first report identifying a deacetylase-independent function for HDAC3, which serves as a specific carrier molecule that targets a specifically phosphorylated protein to promyelocytic leukemia (PML) nuclear bodies.
Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression.
Wei et al., Minneapolis, United States. In Proc Natl Acad Sci U S A, 2008
Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression
Gene silencing by nuclear orphan receptors.
Dufau et al., Bethesda, United States. In Vitam Horm, 2003
In particular, gene-silencing events elicited by chicken ovalbumin upstream promoter-transcription factors (COUP-TFs); dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX-1); germ cell nuclear factor (GCNF); short heterodimer partner (SHP); and testicular receptors 2 and 4 (TR2 and TR4) are among the best characterized.
Recent advances in the TR2 and TR4 orphan receptors of the nuclear receptor superfamily.
Chang et al., Rochester, United States. In J Steroid Biochem Mol Biol, 2002
The human testicular receptor 2 (TR2) and TR4 orphan receptors are two evolutionarily related proteins belonging to the nuclear receptor superfamily.
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