The MAOA, COMT, MTHFR and ESR1 gene polymorphisms are associated with the risk of depression in menopausal women.
Poznań, Poland. In Maturitas, Feb 2016
The following candidate genes were selected for the study: 5HTR2A, 5HTR1B, 5HTR2C, TPH1, TPH2, MAOA, COMT, NET, GABRB1, ESR1, MTHFR, MTR and MTHFD1.
Imaging genetics studies on monoaminergic genes in major depressive disorder.
Seoul, South Korea. In Prog Neuropsychopharmacol Biol Psychiatry, Feb 2016
This paper attempts to provide a comprehensive review of available imaging genetics studies, including reports on genetic variants that have most frequently been linked to MDD, such as the monoaminergic genes (serotonin transporter gene, monoamine oxidase A gene, tryptophan hydroxylase-2 gene, serotonin receptor 1A gene and catechol-O-methyl transferase gene), with regard to key structures involved in emotion processing, such as the hippocampus, amygdala, anterior cingulate cortex and orbitofrontal cortex.
Generation of serotonin neurons from human pluripotent stem cells.
Madison, United States. In Nat Biotechnol, Jan 2016
The serotonin neurons express a series of molecules essential for serotonergic development, including tryptophan hydroxylase 2, exhibit typical electrophysiological properties and release serotonin in an activity-dependent manner.
Serotonergic gene variation in substance use pharmacotherapy: a systematic review.
Houston, United States. In Pharmacogenomics, 2014
Current evidence suggests that genetic variability of the serotonergic biosynthesis enzyme tryptophan hydroxylase 2 (TPH2) and the serotonin transporter (SLC6A4) genes mediates the efficacy of several addiction treatments, such as ondansetron and disulfiram, and the antidepressants bupropion, nortriptyline and sertraline.
[Brain-derived neurotrophic factor: the influence on the genetically and epigenetically determined behavioral disorders].
In Ross Fiziol Zh Im I M Sechenova, 2013
The review provides evidence that: 1) genes encoding key elements of the brain serotonergic system (tryptophan hydroxylase-2, 5-HT1A and 5-HT2A receptors) are implicated in the effect ofBDNF; 2) acute central administration of BDNF produced long-term ameliorative effects on some animal models of genetically defined behavior disorders; 3) BDNF decreased behavioral disorders induced by prenatal stress and ethanol exposure and may play an important role in the treatment of epigenetically defined pathological behavior.