Calcium Channel Mutations in Cardiac Arrhythmia Syndromes.
Lancaster, United States. In Curr Mol Pharmacol, 2014
Activation of the L-type voltagegated calcium channel provides the calcium entry required for excitation-contraction coupling and contributes to the plateau phase of the cardiac action potential.
Gummy smile: could it be genetic? Hereditary gingival fibromatosis.
Memphis, United States. In J Mich Dent Assoc, 2012
Other implicated factors include systemic drugs, such as Phenytoin (Dilantin) taken by epileptic patients, Calcium Channel Blockers such as Nifedipine (Procardia) and Verapamil (Calan) for the treatment of hypertension, arrhythmia and angina.
NAADP mobilizes calcium from acidic organelles through two-pore channels.
Edinburgh, United Kingdom. In Nature, 2009
Here we show that two-pore channels (TPCs) comprise a family of NAADP receptors, with human TPC1 (also known as TPCN1) and chicken TPC3 (TPCN3) being expressed on endosomal membranes, and human TPC2 (TPCN2) on lysosomal membranes when expressed in HEK293 cells.
The Voltage-Gated Calcium Channel and Absence Epilepsy
Bethesda, United States. In Unknown Journal, 0001
In this circuit, the P/Q-type calcium channel encoded by Cacna1a regulates membrane excitability in dendrites, dynamic subthreshold oscillations in somas, and neurotransmitter release at presynaptic terminals.