Calcium Channel Mutations in Cardiac Arrhythmia Syndromes.
Lancaster, United States. In Curr Mol Pharmacol, 2014
Activation of the L-type voltagegated calcium channel provides the calcium entry required for excitation-contraction coupling and contributes to the plateau phase of the cardiac action potential.
NAADP mobilizes calcium from acidic organelles through two-pore channels.
Edinburgh, United Kingdom. In Nature, 2009
Here we show that two-pore channels (TPCs) comprise a family of NAADP receptors, with human TPC1 (also known as TPCN1) and chicken TPC3 (TPCN3) being expressed on endosomal membranes, and human TPC2 (TPCN2) on lysosomal membranes when expressed in HEK293 cells.