Maternal organism and embryo biosensoring: insights from ruminants.
Jouy-le-Moutier, France. In J Reprod Immunol, Apr 2015
Interferon-tau has been recognised to be the major signal of pregnancy recognition, but prostaglandins and lysophospholipids have also been demonstrated to be critical players at the conceptus-endometrium interface.
Loss of the tumor suppressor BAP1 causes myeloid transformation.
San Francisco, United States. In Science, 2012
results identify a potent tumor suppressor function for BAP1 in myeloid neoplasia; propose that BAP1 forms a core complex with HCF-1 and OGT that can differentially recruit additional histone-modifying enzymes to regulate gene expression and preserve norm
Regulation of IgA responses in cattle, humans and mice.
Galveston, United States. In Vet Immunol Immunopathol, 2011
In previous studies in cattle, IgA has been shown to be regulated by several cytokines including IFN-gamma, Type I interferons such as IFN-alpha and IFN-tau, transforming growth factor beta, IgA inducing peptide and other potential factors such as APRIL and BlyS which have not yet been fully evaluated in cattle.
The clinical diagnosis of POLG disease and other mitochondrial DNA depletion disorders.
Cleveland, United States. In Methods, 2010
Mitochondrial DNA depletion is caused by germline deletions and duplications of segments within the mtDNA as well as germline mutations in the nuclear genes responsible for mtDNA duplication (the polymerase apparatus including POLG, POLG2 and PEO1) and mtDNA maintenance (those genes that regulate the deoxynucleotide triphosphate pools and other functions including TP1, TK2, DGUOK, SUCLA1, SUCLA2, ANT1, RRM2B and MPV17).