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Fas apoptotic inhibitory molecule 3

TOSO, FAIM3, Fas apoptotic inhibitory molecule 3
Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010] (from NCBI)
Top mentioned proteins: IgM, CAN, PrP, HAD, POLYMERASE
Papers on TOSO
The application of anti-Toso antibody enhances CD8(+) T cell responses in experimental malaria vaccination and disease.
New
Jacobs et al., Hamburg, Germany. In Vaccine, Dec 2015
Toso is a molecule highly expressed on B cells.
A molecular biomarker to diagnose community-acquired pneumonia on intensive care unit admission.
New
van der Poll et al., Utrecht, Netherlands. In Am J Respir Crit Care Med, Nov 2015
A 78-gene signature was defined for CAP, from which a FAIM3:PLAC8 gene expression ratio was derived with area under curve of 0.845 (95% confidence interval, 0.764-0.917)
Transcriptomic and epigenetic analyses reveal a gender difference in aging-associated inflammation: the Vitality 90+ study.
New
Jylhävä et al., Tampere, Finland. In Age (dordr), Aug 2015
Among these genes were IL1RN, CREB5, and FAIM3, which mapped to a network of inflammatory response genes.
Nomenclature of Toso, Fas apoptosis inhibitory molecule 3, and IgM FcR.
New
Coligan et al., Essen, Germany. In J Immunol, Jun 2015
Hiromi Kubagawa and John E. Coligan coordinated an online meeting to define an appropriate nomenclature for the cell surface glycoprotein presently designated by different names: Toso, Fas apoptosis inhibitory molecule 3 (FAIM3), and IgM FcR (FcμR).
Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection.
Lang et al., Düsseldorf, Germany. In Cell Death Differ, 2015
We observed that intrinsic expression of Toso (Faim3, FcμR) influenced the differentiation and activation of iDCs in vivo and DCs in vitro.
Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells.
Mak et al., Toronto, Canada. In Proc Natl Acad Sci U S A, 2014
The surface receptor Toso/Faim3 has been linked to apoptosis, IgM binding, and innate immune responses.
The old but new IgM Fc receptor (FcμR).
Review
Honjo et al., Birmingham, United States. In Curr Top Microbiol Immunol, 2013
Since the FcμR we cloned was identical to Toso or Fas inhibitory molecule 3 (FAIM3), there have been spirited debates regarding the real function of FcμR/Toso/FAIM3 and we will also comment on this topic.
Involvement of Toso in activation of monocytes, macrophages, and granulocytes.
Mak et al., Toronto, Canada. In Proc Natl Acad Sci U S A, 2013
However, the role of the putative Fc receptor for IgM, known as Toso/Faim3, has to this point been unclear.
Complement-activating IgM enhances the humoral but not the T cell immune response in mice.
Heyman et al., Uppsala, Sweden. In Plos One, 2012
Moreover, the recently discovered murine IgM Fc receptor (FcµR or TOSO/FAIM3) was shown to affect antibody responses.
[Study on histone deacetylase inhibitor LBH589 induces apoptosis of multiple myeloma cells and its reversal of drug resistance mechanism].
Jia et al., Taiyuan, China. In Zhonghua Xue Ye Xue Za Zhi, 2012
The expression level of histone H4 acetylation and PARP, Bcl-X protein was analyzed by western blot, expression level of caspase-3, APAF-1 and TOSO gene by real-time fluorescence quantitative PCR.
Synovial fluid mononuclear cell gene expression profiling suggests dysregulation of innate immune genes in enthesitis-related arthritis patients.
Aggarwal et al., Lucknow, India. In Rheumatology (oxford), 2012
Among genes involved with immune function, cluster of differentiation (CD)1b, CD1d, MHC class II alpha and beta chain, and soluble CD163 were overexpressed, whereas genes related to NK cell function, namely, Granzyme H, killer cell lectin-like receptor subfamily F member 1, killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail (KIR3DL3), natural killer group 7 (NKG7) and other genes like CD244, CD248 and Fas apoptotic inhibitory molecule 3 (FAIM3) were underexpressed.
Toso, a functional IgM receptor, is regulated by IL-2 in T and NK cells.
GeneRIF
Coligan et al., Rockville, United States. In J Immunol, 2012
Toso/FcmuR is an IgM receptor capable of activating signaling molecules and whose expression alone is not inherently antiapoptotic.
TOSO promotes β-cell proliferation and protects from apoptosis.
Maedler et al., Bremen, Germany. In Mol Metab, 2011
Here we show that switching off the Fas pathway using Fas apoptotic inhibitory protein (Faim/TOSO), which regulates apoptosis upstream of caspase 8, blocked β-cell apoptosis and increased proliferation in human islets.
Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (FcμR) in patients with chronic lymphocytic leukemia.
GeneRIF
Kubagawa et al., Birmingham, United States. In Blood, 2011
Enhanced levels of both membrane-bound and soluble forms of FcmuR in CLL patients.
TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation.
GeneRIF
Wiestner et al., Bethesda, United States. In J Immunol, 2011
TOSO/FAIM3 may play a role in immune surveillance and contribute to B cell activation
Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination.
GeneRIF
Lee et al., Germany. In Blood, 2011
we demonstrate that the immune specific cell surface molecule Toso exhibits antiapoptotic effects on death receptor signaling by a novel regulatory mechanism involving the adaptor kinase RIP1
[Expression and prognostic significance of TOSO in CD19+ B cells from Chinese CLL patients].
GeneRIF
Qiu et al., Tianjin, China. In Zhonghua Yi Xue Za Zhi, 2011
Overexpression of TOSO in chronic lymphocytic leukemia is associated with disease progression.
Overexpression of the Fas-inhibitory molecule TOSO: a novel antiapoptotic factor in chronic lymphocytic leukemia.
Review
GeneRIF
Wendtner et al., Köln, Germany. In Leuk Lymphoma, 2009
TOSO as a mediator of resistance to apoptosis in chronic lymphocytic leukemia [review]
Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells.
Impact
Nolan et al., Stanford, United States. In Immunity, 1998
Using retroviral cDNA library-based functional cloning we identified a gene, toso, that blocks Fas-mediated apoptosis.
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