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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

TOR1 Tor1p

TOR1, Tor1p, DRR1
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Top mentioned proteins: ACID, CD1, CAN, V1a, mTORC1
Papers on TOR1
The stressed cytoskeleton: How actin dynamics can shape stress-related consequences on synaptic plasticity and complex behavior.
Müller et al., Mainz, Germany. In Neurosci Biobehav Rev, Jan 2016
Identified stress-responsive ABPs include: tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1), ADF/cofilin, LIMK1, caldesmon and myosin VI.
Affected chromosome homeostasis and genomic instability of clonal yeast cultures.
Wnuk et al., Rzeszów, Poland. In Curr Genet, Dec 2015
Chromosome-dependent and mutation-dependent changes in DNA (DNA with breaks or with abnormal replication intermediates) were studied using both single-gene deletion haploid mutants (bub1, bub2, mad1, tel1, rad1 and tor1) and diploid cells lacking one active gene of interest, namely BUB1/bub1, BUB2/bub2, MAD1/mad1, TEL1/tel1, RAD1/rad1 and TOR1/tor1 involved in the control of cell cycle progression, DNA repair and the regulation of longevity.
Chediak-Higashi syndrome: Lysosomal trafficking regulator domains regulate exocytosis of lytic granules but not cytokine secretion by natural killer cells.
Krzewski et al., Huddinge, Sweden. In J Allergy Clin Immunol, Nov 2015
METHODS: We analyzed NK cells from patients with CHS with missense mutations in the LYST ARM/HEAT (armadillo/huntingtin, elongation factor 3, protein phosphatase 2A, and the yeast kinase TOR1) or BEACH (beige and Chediak-Higashi) domains.
The yeast chromatin remodeler Rsc1-RSC complex is required for transcriptional activation of autophagy-related genes and inhibition of the TORC1 pathway in response to nitrogen starvation.
Tsuchiya et al., Hiroshima, Japan. In Biochem Biophys Res Commun, Oct 2015
Interestingly, decreased autophagic activity and Atg8 protein stability in rsc1Δ cells, but not the defect in ATG8 mRNA expression, were partially suppressed by deletion of TOR1.
Tor1, Sch9 and PKA downregulation in quiescence rely on Mtl1 to preserve mitochondrial integrity and cell survival.
de la Torre-Ruiz et al., Lleida, Spain. In Mol Microbiol, Jul 2015
We demonstrate that all these effects are a consequence of signalling defects suppressed by TOR1 (target of rapamycin) and SCH9 deletion and less efficiently by Protein kinase A (PKA) inactivation.
Both the autophagy and proteasomal pathways facilitate the Ubp3p-dependent depletion of a subset of translation and RNA turnover factors during nitrogen starvation in Saccharomyces cerevisiae.
Bedwell et al., Birmingham, United States. In Rna, May 2015
The proteasome-dependent depletion of Dcp2p and Pop2p was also induced by rapamycin, suggesting that the TOR1 pathway influences this pathway.
Constitutive Tor2 Activity Promotes Retention of the Amino Acid Transporter Agp3 at Trans-Golgi/Endosomes in Fission Yeast.
Furuyashiki et al., Kōbe, Japan. In Plos One, 2014
There are two TOR isoforms in fission yeast, Tor1 and Tor2.
Selection of Orthologous Genes for Construction of a Highly Resolved Phylogenetic Tree and Clarification of the Phylogeny of Trichosporonales Species.
Sugita et al., Tsukuba, Japan. In Plos One, 2014
In addition, we found that several genes, such as phosphatidylinositol 3-kinase TOR1 and glutamate synthase (NADH), had good resolution in this group (even when used alone).
Transient sequestration of TORC1 into stress granules during heat stress.
Maeda et al., Tokyo, Japan. In Mol Cell, 2012
TORC1 signaling is coupled to heat-induced SGs to protect cells from DNA damage
Rapid cytoplasmic turnover of yeast ribosomes in response to rapamycin inhibition of TOR.
Shcherbik et al., United States. In Mol Cell Biol, 2012
ribosome content is regulated dynamically in eukaryotes by TOR through both ribosome synthesis and the cytoplasmic turnover of mature ribosomes.
Nutrient limitations alter cell division control and chromosome segregation through growth-related kinases and phosphatases.
Sajiki et al., Okinawa, Japan. In Philos Trans R Soc Lond B Biol Sci, 2012
In tor1 and ssp1 mutants, cell elongation is observed.
The TEA transcription factor Tec1 links TOR and MAPK pathways to coordinate yeast development.
Mösch et al., Marburg an der Lahn, Germany. In Genetics, 2011
Data show that Tec1 protein stability is under control of the nutrient-sensitive target of rapamycin complex 1 (TORC1) signaling pathway via the Tip41-Tap42-Sit4 branch.
Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling.
Shadel et al., New Haven, United States. In Cell Metab, 2011
extension of chronological life span by reduced TOR1 complex/Sch9p-mitochondrial signaling occurs independently of Rim15p and is not a function of changes in media acidification/composition
Mapping the interaction of Snf1 with TORC1 in Saccharomyces cerevisiae.
Nielsen et al., Göteborg, Sweden. In Mol Syst Biol, 2010
TORC1 regulates FA metabolism, likely through modulating the peroxisome and beta-oxidation. direct interactions between Snf1 and TORC1 pathways are unlikely under nutrient-limited conditions.
Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression.
Shadel et al., New Haven, United States. In Cell Metab, 2007
Deletion of the TOR1 gene extends chronological life span in Saccharomyces cerevisiae.
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.
Kennedy et al., Seattle, United States. In Science, 2005
Calorie restriction of tor1D or sch9D cells failed to further increase life span and, like calorie restriction, deletion of either SCH9 or TOR1 increased life span independent of the Sir2 histone deacetylase.
[Genetic mechanisms of realization of the law of limiting factor in Saccharomyces cerevisiae].
Sambuk, In Zh Obshch Biol, 2005
According to this model, phosphoprotein kinase (Tor1p, Tor2p, Snf1p or Pho85p) that regulates corresponding metabolic pathway receives a signal about the limiting factor and become dominated kinase.
The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors.
Hall et al., Basel, Switzerland. In Nature, 2000
The TOR1 and TOR2 kinases (TOR) control cytoplasmic protein synthesis and degradation through the conserved TAP42 protein.
A mammalian protein targeted by G1-arresting rapamycin-receptor complex.
Schreiber et al., Cambridge, United States. In Nature, 1994
Peptide sequences from purified bovine FRAP were used to isolate a human cDNA clone that is highly related to the DRR1/TOR1 and DRR2/TOR2 gene products from Saccharomyces cerevisiae.
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression.
Hall et al., Basel, Switzerland. In Cell, 1993
The immunosuppressant rapamycin most likely acts by inhibiting PI kinase activity because TOR2 mutations confer resistance to rapamycin and because a TOR1 TOR2 double disruption (TOR1 is a nonessential TOR2 homolog) confers G1 arrest, as does rapamycin.
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