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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Thimet oligopeptidase 1

TOP, thimet oligopeptidase, endopeptidase 24.15, EP24.15
Top mentioned proteins: CAN, ACID, Angiotensin II, HAD, V1a
Papers using TOP antibodies
Binding of the La autoantigen to the 5′ untranslated region of a chimeric human translation elongation factor 1A reporter mRNA inhibits translation in vitro
Supplier
Chen Runsheng et al., In Nucleic Acids Research, 2000
... TOP promoter elements control the relative ratio of intron-encoded snoRNA versus spliced mRNA biosynthesis ...
Papers on TOP
An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis.
New
Umar et al., Kansas City, United States. In Carcinogenesis, Feb 2016
TOP-flash reporter activity, a measure of Wnt signaling, decreased significantly in response to treatment while overexpression of wild type but not mutant EZH2, reversed the inhibitory effects.
Docosahexaenoic Acid Promotes Axon Outgrowth by Translational Regulation of Tau and Collapsin Response Mediator Protein 2 Expression.
New
Sobue et al., Japan. In J Biol Chem, Feb 2016
In addition, the DHA-dependent activation of the Akt-mTOR-S6K pathway enhanced the 5' terminal oligopyrimidine tract (5'-TOP)-dependent translation of Tau and CRMP2.
Pin1-mediated modification prolongs the nuclear retention of β-catenin in Wnt3a-induced osteoblast differentiation.
New
Ryoo et al., Seoul, South Korea. In J Biol Chem, Feb 2016
Similarly, Pin1 knock-down or the treatment of Pin1 inhibitors strongly decreased nuclear β-catenin level, the TOP flash activity and the expression of bone marker genes induced by canonical Wnt activation, and vice versa in Pin1 overexpression.
Meta-analysis supporting noninferiority of oxaliplatin plus S-1 to cisplatin plus S-1 in first-line treatment of advanced gastric cancer (G-SOX study): indirect comparison with S-1 alone.
New
Hyodo et al., Tokyo, Japan. In Int J Clin Oncol, Feb 2016
Individual patient data for SOX (318 patients) and CS (324 patients) from G-SOX, as well as those for S-1 (160 patients) from the Randomized Phase III Study Comparing the Efficacy and Safety of Irinotecan plus S-1 with S-1 Alone as First-line Treatment for Advanced Gastric Cancer (GC0301/TOP-002), were available.
Biomarkers in triple negative breast cancer: A review.
Review
New
Jhamb et al., Chandīgarh, India. In World J Clin Oncol, Jan 2016
We included studies with biomarkers including: Epidermal growth factor receptor, vascular endothelial growth factor, c-Myc, C-kit and basal cytokeratins, Poly(ADP-ribose) polymerase-1, p53, tyrosinase kinases, m-TOR, heat and shock proteins and TOP-2A in TNBC.
Decreased expression of MEG3 contributes to retinoblastoma progression and affects retinoblastoma cell growth by regulating the activity of Wnt/β-catenin pathway.
Review
New
Lu et al., Guangzhou, China. In Tumour Biol, Jan 2016
TOP-Flash reporter assay was also used to investigate the activity of the Wnt/β-catenin pathway.
Human topoisomerase II alpha as a prognostic biomarker in cancer chemotherapy.
Review
New
Abd Hamid et al., Kuantan, Malaysia. In Tumour Biol, Nov 2015
Among all forms of topoisomerases, TOP-IIA is extensively associated with cell proliferation and therefore is an important therapeutic target in diseases that involved cellular proliferation such as cancers.
Integrative analysis of aberrant Wnt signaling in hepatitis B virus-related hepatocellular carcinoma.
Review
New
Lu et al., Beijing, China. In World J Gastroenterol, Jun 2015
Dual-luciferase reporter assay was performed with TOP/FOP reporters to detect whether TP53 gain-of-function (GOF) mutations could enhance the transcriptional activity of Wnt signaling.
Regulation of global and specific mRNA translation by the mTOR signaling pathway.
Review
Roux et al., Montréal, Canada. In Translation (austin), 2015
Whereas mTOR controls global protein synthesis through specific effector proteins, its role in the translation of select groups of mRNAs, such as those harboring a terminal oligopyrimidine (TOP) tract at their 5' end, remains more enigmatic.
Inhibitory effect of DNA topoisomerase inhibitor isoliquiritigenin on the growth of glioma cells.
Jin et al., Xinxiang, China. In Int J Clin Exp Pathol, 2014
OBJECTIVE: To investigate the effect of isoliquiritigenin on the activity of DNA topoisomerase (TOP I) and its inhibitory effect on the growth of U87 glioma cells.
Parallel measurement of dynamic changes in translation rates in single cells.
Impact
Meyer et al., Stanford, United States. In Nat Methods, 2014
Application of the method showed that individual cells undergo marked fluctuations in the translation rate of mRNAs whose 5' terminal oligopyrimidine (5' TOP) motif regulates the synthesis of ribosomal proteins.
A unifying model for mTORC1-mediated regulation of mRNA translation.
Impact
Sabatini et al., Boston, United States. In Nature, 2012
The subset of mRNAs that are specifically regulated by mTORC1 consists almost entirely of transcripts with established 5' terminal oligopyrimidine (TOP) motifs, or, like Hsp90ab1 and Ybx1, with previously unrecognized TOP or related TOP-like motifs that we identified.
Multifactorial approach to predicting resistance to anthracyclines.
Impact
Sotiriou et al., Brussels, Belgium. In J Clin Oncol, 2011
The neoadjuvant Trial of Principle (TOP) study, in which patients with estrogen receptor (ER) -negative tumors were treated with anthracycline (epirubicin) monotherapy, was specifically designed to evaluate the predictive value of topoisomerase II-α (TOP2A) and develop a gene expression signature to identify those patients who do not benefit from anthracyclines.
Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes.
Impact
GeneRIF
Melief et al., Leiden, Netherlands. In Nat Immunol, 2011
mediates antigen processing that generates cytotoxic T cell epitopes
Nuclear Thimet oligopeptidase is coexpressed with oestrogen receptor alpha in hypothalamic cells and regulated by oestradiol in female mice.
GeneRIF
Wolfson et al., Wellesley, United States. In J Neuroendocrinol, 2010
Data show that Thimet oligopeptidase (TOP) is coexpressed with estrogen receptor alpha, and estradiol regulates TOP expression in a brain region-specific manner in female mice.
Interaction with calmodulin is important for the secretion of thimet oligopeptidase following stimulation.
GeneRIF
Ferro et al., São Paulo, Brazil. In Febs J, 2009
interaction between EP24.15 and calmodulin is regulated within cells and is important for the stimulated secretion of EP24.15 from HEK293 cells.
Analysis of intracellular substrates and products of thimet oligopeptidase in human embryonic kidney 293 cells.
GeneRIF
Fricker et al., São Paulo, Brazil. In J Biol Chem, 2009
Over 100 peptides were identified in human embryonic kidney 293 (HEK293) cells that are derived from intracellular proteins; many but not all of these peptides are substrates or products of EP24.15.
Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction.
Impact
Thomas et al., In Nat Cell Biol, 2009
However, disruption of biogenesis of 40S ribosomes had no effect on nucleolar integrity, although p53 induction was mediated by rpL11, leading to the finding that the cell selectively upregulates the translation of mRNAs with a polypyrimidine tract at their 5'-transcriptional start site (5'-TOP mRNAs), including that encoding rpL11, on impairment of 40S ribosome biogenesis.
Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity.
GeneRIF
Terstappen et al., Siena, Italy. In Neurobiol Dis, 2008
increase in THOP1 expression might be part of a compensatory defense mechanism of the brain against an increased Abeta load.
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