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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Nuclear factor of activated T-cells 5, tonicity-responsive

The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, CAN, Rel, p38, MAPK
Papers using TonEBP antibodies
Exclusion of NFAT5 from mitotic chromatin resets its nucleo-cytoplasmic distribution in interphase
Aramburu Jose et al., In Nucleic Acids Research, 2008
... Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice ...
Overexpression of HSP-72 confers cytoprotection in experimental peritoneal dialysis
Neuhofer Wolfgang et al., In Mediators of Inflammation, 2003
... Anti-NFAT5 antibody weas from Santa Cruz Biotechnology (Santa Cruz, CA, USA); ...
Papers on TonEBP
Peptide affinity analysis of proteins that bind to an unstructured n-terminal region of the osmoprotective transcription factor NFAT5.
Ferraris et al., Kumamoto, Japan. In Physiol Genomics, Feb 2016
UNASSIGNED: NFAT5 is an osmoregulated transcription factor that particularly increases expression of genes involved in protection against hypertonicity.
How do kinases contribute to tonicity-dependent regulation of the transcription factor NFAT5?
Zhou, Bethesda, United States. In World J Nephrol, Feb 2016
NFAT5 plays a critical role in maintaining the renal functions.
Osmolar regulation of endothelin-1 production by the inner medullary collecting duct.
Kohan et al., Salt Lake City, United States. In Life Sci, Dec 2015
Inhibition of NFAT5 with rottlerin or NFAT5 siRNA greatly reduced the stimulatory effect of osmolality alone and osmolality + flow on mIMCD3 ET-1 mRNA levels.
Cutaneous Na+ storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense.
Titze et al., Erlangen, Germany. In Cell Metab, Apr 2015
Activation of macrophages in the presence of high NaCl concentrations modified epigenetic markers and enhanced p38 mitogen-activated protein kinase (p38/MAPK)-dependent nuclear factor of activated T cells 5 (NFAT5) activation.
Salt and gene expression: evidence for [Na+]i/[K+]i-mediated signaling pathways.
Hamet et al., Moscow, Russia. In Pflugers Arch, Mar 2015
Side-by-side with sensing of osmolality elevation by tonicity enhancer-binding protein (TonEBP, NFAT5), [Na+]i/[K+]i-mediated excitation-transcription coupling may contribute to the transcriptomic changes evoked by high salt consumption.
Transcriptomic and genetic studies identify NFAT5 as a candidate gene for cocaine dependence.
Cormand et al., Barcelona, Spain. In Transl Psychiatry, 2014
This study highlighted associations between cocaine dependence and five SNPs predicted to alter microRNA binding at the 3'-untranslated region of the NFAT5 gene.
The Potential Role of NFAT5 and Osmolarity in Peritoneal Injury.
Segerer et al., Zürich, Switzerland. In Biomed Res Int, 2014
A rise in osmotic concentration (osmolarity) activates the transcription factor Nuclear Factor of Activated T Cells 5 (NFAT5, also known as Tonicity-responsive Enhancer Binding Protein, TonEBP).
High-Salt Enhances the Inflammatory Response by Retina Pigment Epithelium Cells following Lipopolysaccharide Stimulation.
Yang et al., Chongqing, China. In Mediators Inflamm, 2014
Coculture of ARPE-19 cells with NaCl resulted in significant increases in the phosphorylation of p38 MAPK, Akt, and NF-κB and an upregulation of the transcription factors NFAT5 and SGK1.
TonEBP modulates the protective effect of taurine in ischemia-induced cytotoxicity in cardiomyocytes.
Zuo et al., Shanghai, China. In Cell Death Dis, 2014
In this study, we describe the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway involved in the taurine-regulated TauT expression in ischemic CMs.
Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: evolving role of TonEBP.
Risbud et al., Philadelphia, United States. In Matrix Biol, 2014
The transcription factor Tonicity-Responsive Enhancer Binding Protein (TonEBP or NFAT5) is known to mediate the osmoadaptive response in these and other tissues.
Macrophages in homeostatic immune function.
Titze et al., Erlangen, Germany. In Front Physiol, 2013
Particularly, we summarize the importance of macrophage tonicity enhancer binding protein (TonEBP, also termed nuclear factor of activated T-cells 5 [NFAT5]) expression in the regulation of salt and water homeostasis.
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Hafler et al., New Haven, United States. In Nature, 2013
High-salt conditions activate the p38/MAPK pathway involving nuclear factor of activated T cells 5 (NFAT5; also called TONEBP) and serum/glucocorticoid-regulated kinase 1 (SGK1) during cytokine-induced TH17 polarization.
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
Gieger et al., Freiburg, Germany. In Nat Genet, 2013
By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4).
Nonstructural 5A protein of hepatitis C virus regulates heat shock protein 72 for its own propagation.
Hwang et al., Anyang, South Korea. In J Viral Hepat, 2012
These data indicate that NS5A modulates Hsp72 via NFAT5 and reactive oxygen species activation for hepatitis C virus propagation.
Gene expression induced by Toll-like receptors in macrophages requires the transcription factor NFAT5.
López-Rodríguez et al., Barcelona, Spain. In J Exp Med, 2012
NFAT5 was necessary for effective immunity against Leishmania major, a parasite whose clearance requires TLRs and iNOS expression in macrophages.
Regulation of Mycobacterium tuberculosis-dependent HIV-1 transcription reveals a new role for NFAT5 in the toll-like receptor pathway.
Goldfeld et al., Boston, United States. In Plos Pathog, 2011
the innate immune response to MTb infection induces NFAT5 gene and protein expression, and NFAT5 plays a crucial role in MTb regulation of HIV-1 replication via a direct interaction with the viral promoter.
NFAT5 contributes to osmolality-induced MCP-1 expression in mesothelial cells.
Neuhofer et al., München, Germany. In Mediators Inflamm, 2011
NFAT5 contributes to osmolality-induced MCP-1 expression in mesothelial cells
NFAT5 is activated by hypoxia: role in ischemia and reperfusion in the rat kidney.
Irarrazabal et al., Santiago, Chile. In Plos One, 2011
NFAT5 is induced by hypoxia and could be a protective factor against ischemic damage.
Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.
Titze et al., Nürnberg, Germany. In Nat Med, 2009
The mechanisms underlying these effects on lymphatics involve activation of tonicity-responsive enhancer binding protein (TonEBP) in mononuclear phagocyte system (MPS) cells infiltrating the interstitium of the skin.
Cellular response to hyperosmotic stresses.
Dmitrieva et al., Bethesda, United States. In Physiol Rev, 2007
We speculate on the sensors of osmolality and document the multiple pathways that signal activation of the transcription factor TonEBP/OREBP, which directs many aspects of adaptation.
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