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Translocase of outer mitochondrial membrane 70 homolog A

TOMM70A, KIAA0719
This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: TFAM, AGE, HDAC, ACID, Histone
Papers on TOMM70A
The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance.
Corti et al., Paris, France. In Autophagy, 2013
PD-causing PARK2 mutations weakened or disrupted the molecular interaction between PARK2 and specific TOMM subunits: the surface receptor, TOMM70A, and the channel protein, TOMM40.
Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells.
Lisanti et al., Jefferson, United States. In Cell Cycle, 2013
Second, during validation by immunohistochemistry, we observed that antibodies directed against 15 markers of mitochondrial biogenesis and/or mitochondrial translation (AKAP1, GOLPH3, GOLPH3L, MCT1, MRPL40, MRPS7, MRPS15, MRPS22, NRF1, NRF2, PGC1-α, POLRMT, TFAM, TIMM9 and TOMM70A) selectively labeled epithelial breast cancer cells.
Translocase of outer mitochondrial membrane 70 induces interferon response and is impaired by hepatitis C virus NS3.
GeneRIF
Tsukiyama-Kohara et al., Kumamoto, Japan. In Virus Res, 2012
The hepatitis C virus NS3/4A protein induced Tom70 expression.
Interaction between the human mitochondrial import receptors Tom20 and Tom70 in vitro suggests a chaperone displacement mechanism.
GeneRIF
Young et al., Montréal, Canada. In J Biol Chem, 2011
a novel model in which Tom20 binds Tom70 to facilitate preprotein release from the chaperones by competition
Stoichiometry and thermodynamics of the interaction between the C-terminus of human 90kDa heat shock protein Hsp90 and the mitochondrial translocase of outer membrane Tom70.
GeneRIF
Ramos et al., Campinas, Brazil. In Arch Biochem Biophys, 2011
used biophysical tools to study the interaction between the C-terminal domain of Hsp90 (C-Hsp90), which contains the EEVD motif that binds to TPR domains, and the cytosolic fragment of Tom70
Translocase of outer mitochondrial membrane 70 expression is induced by hepatitis C virus and is related to the apoptotic response.
GeneRIF
Tsukiyama-Kohara et al., Kumamoto, Japan. In J Med Virol, 2011
This study revealed a novel finding, that is, human TOM70 is linked with the hepatitis C virus NS3 protein and the apoptotic response.
Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disorders.
Thomas et al., Los Angeles, United States. In Transl Psychiatry, 2010
We find that promoter-associated ac-H3K9K14 levels are correlated with gene expression levels, as measured by real-time qPCR for several genes, including, glutamic acid decarboxylase 1 (GAD1), 5-hydroxytryptamine receptor 2C (HTR2C), translocase of outer mitochondrial membrane 70 homolog A (TOMM70A) and protein phosphatase 1E (PPM1E).
Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.
GeneRIF
Wang et al., Shanghai, China. In Cell Res, 2010
Tom70 as a critical adaptor linking MAVS to TBK1/IRF3, revealing that mitochondrion is evolutionarily integrated with innate immunity.
Characterization of a human import component of the mitochondrial outer membrane, TOMM70A.
GeneRIF
Argyropoulos et al., Charleston, United States. In Cell Commun Adhes, 2002
TOMM70A is ubiquitously expressed in human tissues, maps on chromosome 3q13.1-q13.2 and consists of 12 coding exons spanning over 37 kb.
Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions.
Muñoz et al., Madrid, Spain. In J Neurochem, 1999
S2 was identified as KIAA0719, the first human gene distantly homologous to the fungal Tom70, which encodes a member of the translocase mitochondrial outer membrane complex involved in the import of preproteins into the mitochondria.
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