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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 Apr 2016.

TOM40 Tom40p

Tom40, ISP42, TOMM40
TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for protein import into mitochondria (Humphries et al., 2005 [PubMed 15644312]).[supplied by OMIM, May 2008] (from NCBI)
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Top mentioned proteins: apolipoprotein E, AGE, HAD, Apolipoprotein C-I, ACID
Papers on Tom40
Associations between TOMM40 Poly-T Repeat Variants and Dementia in Cases with Parkinsonism.
New
Hansson et al., Lund, Sweden. In J Parkinsons Dis, Feb 2016
OBJECTIVE: To investigate the role of the Translocase of the Outer Mitochondrial Membrane 40 homolog (TOMM40) variants in PD without dementia (PDND), PD with dementia (PDD) and in Dementia with Lewy bodies (DLB).
Combined Plasma and Cerebrospinal Fluid Signature for the Prediction of Midterm Progression From Mild Cognitive Impairment to Alzheimer Disease.
New
Alzheimer’s Disease Neuroimaging Initiative et al., Basel, Switzerland. In Jama Neurol, Jan 2016
Variables included clinical and demographic data, cognitive scores, magnetic resonance imaging-based brain volumetric data, the apolipoprotein E (APOE) and translocase of outer mitochondrial membrane 40 homolog (TOMM40) genotypes, and analyte levels measured in the CSF and plasma.
Association of common variants in TOMM40/APOE/APOC1 region with human longevity in a Chinese population.
New
Cai et al., Haikou, China. In J Hum Genet, Jan 2016
UNASSIGNED: Apolipoprotein E (APOE), translocase of outer mitochondrial membrane 40 homolog (TOMM40) and apolipoprotein C-I (APOC1) may extend lifespan by marked delay or escape from age-related diseases.
A TOMM40 poly-T variant modulates gene expression and is associated with vocabulary ability and decline in nonpathologic aging.
New
Quinn et al., Manchester, United Kingdom. In Neurobiol Aging, Jan 2016
UNASSIGNED: The Translocase of Outer Mitochondrial Membrane 40 Homolog and Apolipoprotein E (TOMM40-APOE) locus has been associated with a number of age-related phenotypes in humans including nonpathologic cognitive aging, late-onset Alzheimer's disease, and longevity.
Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity.
New
Kim et al., Stanford, United States. In Plos Genet, Dec 2015
In a standard GWAS analysis, only one locus in these studies is significant (APOE/TOMM40) when controlling the false discovery rate (FDR) at 10%.
Combined Genome-Wide CSF Aβ-42's Associations and Simple Network Properties Highlight New Risk Factors for Alzheimer's Disease.
New
Alzheimer’s Disease Neuroimaging Initiative et al., Recife, Brazil. In J Mol Neurosci, Dec 2015
Both methods' results showed two identical significant SNPs associated with the A β-42 levels in CSF (rs2075650 at intron region TOMM40 with p-value ≥ 1 × 10-16 and rs439401 in the intergenic region of LOC100129500 and APOC1 with p-value ≥ 1 × 10-9) and highlighted APOC1 and TOMM40, which are well-known genes previously associated with AD.
Meta-analysis of the rs2075650 polymorphism and risk of Alzheimer disease.
New
Chen et al., China. In Aging Clin Exp Res, Dec 2015
We addressed the controversy through performing a meta-analysis of the relationship between rs2075650 in TOMM40 (translocase of outer mitochondrial membrane 40 homologue) and Alzheimer disease.
Risk prediction for sporadic Alzheimer's disease using genetic risk score in the Han Chinese population.
New
Wu et al., Shanghai, China. In Oncotarget, Dec 2015
including rs9349407 in CD2AP, rs11218343 in SORL1, rs17125944 in FERMT2, rs6859 in PVRL2, rs157580 and rs2075650 in TOMM40.
Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China.
Shen et al., Changsha, China. In Plos One, 2014
Risk SNPs included rs9331888 (CLU), rs6691117 (CR1), rs4938933 (MS4A), rs9349407 (CD2AP), rs1160985 (TOMM40), rs4945261 (GAB2) and rs5984894 (PCDH11X); Protective SNPs consisted of rs744373 (BIN1), rs1562990 (MS4A), rs597668 (EXOC3L2), rs9271192 (HLA-DRB5/DRB1), rs157581 and rs11556505 (TOMM40).
Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers.
Review
Alzheimer’s Disease Neuroimaging Initiative et al., Indianapolis, United States. In Brain Imaging Behav, 2014
Several other genes (e.g., APOC1, FTO, GRIN2B, MAGI2, and TOMM40) were associated with multiple ADNI phenotypes, warranting further investigation on other data sets.
New applications of disease genetics and pharmacogenetics to drug development.
Review
Brannan et al., Durham, United States. In Curr Opin Pharmacol, 2014
The trial is made practical by the use of a pharmacogenetic algorithm based on TOMM40 and APOE genotypes and age to identify normal subjects at high risk of MCI-AD between the ages of 65-83 years within a five year follow-up period.
TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial.
Review
Gottschalk et al., Durham, United States. In Alzheimers Dement, 2013
A number of recent studies have not replicated the association of the translocase of the outer mitochondrial membrane pore subunit (TOMM40) rs10524523 polymorphism, which is in linkage disequilibrium with apolipoprotein E (APOE), with age of onset of Alzheimer's disease (AD).
Downregulation of TOMM40 expression in the blood of Alzheimer disease subjects compared with matched controls.
GeneRIF
Krishnan et al., In J Psychiatr Res, 2012
This study demonistrated that Downregulation of TOMM40 expression in the blood of Alzheimer disease.
Levels of cerebrospinal fluid neurofilament light protein in healthy elderly vary as a function of TOMM40 variants.
GeneRIF
Blennow et al., United States. In Exp Gerontol, 2012
Subjects with APOE epsilon4 have higher CSF NFL levels than non-epsilon4 carriers, only when they do not carry a short poly-T variant of TOMM40, which is associated with later age of onset of AD
Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE.
GeneRIF
Yu et al., Seattle, United States. In J Hum Genet, 2012
The main novel finding of this investigation was that multiple APOE locus cis-elements influence both APOE and TOMM40 promoter activity according to haplotype and cell type.
TOMM40 rs10524523 polymorphism's role in late-onset Alzheimer's disease and in longevity.
GeneRIF
Zekanowski et al., Warsaw, Poland. In J Alzheimers Dis, 2011
This study identi fi ed TOMM40alleles, genotypes,as well asTOMM40-E4haplotypes that in fl uencelongevity.
Characterization of the poly-T variant in the TOMM40 gene in diverse populations.
GeneRIF
Chiba-Falek et al., Durham, United States. In Plos One, 2011
the poly-T, rs10524523 allele frequencies in different ethnicities.
[Risk factors for Alzheimer's disease].
Review
Yamada et al., Kanazawa, Japan. In Brain Nerve, 2010
In addition, several genes such as CTNNA3, GAB2, PVRL2, TOMM40, and APOC1 are known to be the risk factors that contribute to AD pathogenesis.
An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease.
Review
Roses, Durham, United States. In Arch Neurol, 2010
I coauthored a recently published research article describing a variable length, poly-T polymorphism in the TOMM40 gene, adjacent to apolipoprotein E (APOE) on chromosome 19, that accounts for the age at onset distribution for a complex disease, late-onset Alzheimer disease.
A yeast mitochondrial outer membrane protein essential for protein import and cell viability.
Impact
Schatz et al., Basel, Switzerland. In Nature, 1991
The gene encoding ISP42, an integral outermembrane protein located at the yeast mitochondrial protein import site was cloned, sequenced and modified.
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