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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

TOM40 Tom40p

Tom40, ISP42, TOMM40
TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for protein import into mitochondria (Humphries et al., 2005 [PubMed 15644312]).[supplied by OMIM, May 2008] (from NCBI)
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Top mentioned proteins: apolipoprotein E, AGE, HAD, CAN, Tom22
Papers on Tom40
The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes.
New
Chiba-Falek et al., Durham, United States. In Alzheimers Dement, 30 Sep 2014
BACKGROUND: We investigated the genomic region spanning the Translocase of the Outer Mitochondrial Membrane 40-kD (TOMM40) and Apolipoprotein E (APOE) genes, that has been associated with the risk and age of onset of late-onset Alzheimer's disease (LOAD) to determine whether a highly polymorphic, intronic poly-T within this region (rs10524523; hereafter, 523) affects expression of the APOE and TOMM40 genes.
Multiple pathogenic proteins implicated in neuronopathic Gaucher disease mice.
New
Grabowski et al., Cincinnati, United States. In Hum Mol Genet, Sep 2014
A majority of APP co-localized with the mitochondrial markers TOM40 and Cox IV; a small portion co-localized with the autophagy proteins, P62/LC3, and the lysosomal marker, LAMP1.
Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans.
New
Lange et al., Chapel Hill, United States. In Hum Genet, Aug 2014
In the race-combined meta-analyses, 13 loci reached significance, including ten (CRP, TOMM40/APOE/APOC1, HNF1A, LEPR, GCKR, IL6R, IL1RN, NLRP3, HNF4A and BAZ1B/BCL7B) previously associated with CRP, and one (ARNTL) previously reported to be nominally associated with CRP.
TOMM40 rs2075650 may represent a new candidate gene for vulnerability to major depressive disorder.
New
Juhasz et al., Budapest, Hungary. In Neuropsychopharmacology, Jun 2014
A novel gene (TOMM40) has been consistently associated with Alzheimer's disease (AD), but has received no attention in depression.
Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936.
New
Deary et al., Edinburgh, United Kingdom. In Neurobiol Aging, Jun 2014
In the TOMM40 gene, the rs10524523 ("523") variable length poly-T repeat polymorphism has more recently been associated with similar ph/enotypes, although the allelic directions of these associations have varied between initial reports.
Genetic susceptibility to accelerated cognitive decline in the US Health and Retirement Study.
New
Pierce et al., Chicago, United States. In Neurobiol Aging, Jun 2014
region: rs769449 (APOE intron; p = 3.1 × 10(-20)) and rs115881343 (TOMM40 intron; p = 6.6 × 10(-11)).
New applications of disease genetics and pharmacogenetics to drug development.
Review
New
Brannan et al., Durham, United States. In Curr Opin Pharmacol, Feb 2014
The trial is made practical by the use of a pharmacogenetic algorithm based on TOMM40 and APOE genotypes and age to identify normal subjects at high risk of MCI-AD between the ages of 65-83 years within a five year follow-up period.
TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial.
Review
New
Gottschalk et al., Durham, United States. In Alzheimers Dement, Mar 2013
A number of recent studies have not replicated the association of the translocase of the outer mitochondrial membrane pore subunit (TOMM40) rs10524523 polymorphism, which is in linkage disequilibrium with apolipoprotein E (APOE), with age of onset of Alzheimer's disease (AD).
A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
Wu et al., Wuhan, China. In Plos One, 2012
The loci genome wide significantly associated with TC were near DOCK7, HMGCR and ABO; those genome wide significantly associated with TG were near APOA1/C3/A4/A5 and LPL; those genome wide significantly associated with LDL were near HMGCR, ABO and TOMM40; and those genome wide significantly associated with HDL were near LPL, LIPC and CETP.
Random forests on Hadoop for genome-wide association studies of multivariate neuroimaging phenotypes.
Alzheimer's Disease Neuroimaging Initiative et al., In Bmc Bioinformatics, 2012
Several known AD-related variants have been identified, including APOE4 and TOMM40.
TOMM40 in Cerebral Amyloid Angiopathy Related Intracerebral Hemorrhage: Comparative Genetic Analysis with Alzheimer's Disease.
Alzheimer’s Disease Neuroimaging Initiative (ADNI) et al., Boston, United States. In Transl Stroke Res, 2012
Among the genetic loci associated with AD are APOE and TOMM40, a gene in close proximity to APOE.
Downregulation of TOMM40 expression in the blood of Alzheimer disease subjects compared with matched controls.
GeneRIF
Krishnan et al., In J Psychiatr Res, 2012
This study demonistrated that Downregulation of TOMM40 expression in the blood of Alzheimer disease.
Levels of cerebrospinal fluid neurofilament light protein in healthy elderly vary as a function of TOMM40 variants.
GeneRIF
Blennow et al., United States. In Exp Gerontol, 2012
Subjects with APOE epsilon4 have higher CSF NFL levels than non-epsilon4 carriers, only when they do not carry a short poly-T variant of TOMM40, which is associated with later age of onset of AD
Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE.
GeneRIF
Yu et al., Seattle, United States. In J Hum Genet, 2012
The main novel finding of this investigation was that multiple APOE locus cis-elements influence both APOE and TOMM40 promoter activity according to haplotype and cell type.
TOMM40 rs10524523 polymorphism's role in late-onset Alzheimer's disease and in longevity.
GeneRIF
Zekanowski et al., Warsaw, Poland. In J Alzheimers Dis, 2011
This study identi fi ed TOMM40alleles, genotypes,as well asTOMM40-E4haplotypes that in fl uencelongevity.
Characterization of the poly-T variant in the TOMM40 gene in diverse populations.
GeneRIF
Chiba-Falek et al., Durham, United States. In Plos One, 2011
the poly-T, rs10524523 allele frequencies in different ethnicities.
[Risk factors for Alzheimer's disease].
Review
Yamada et al., Kanazawa, Japan. In Brain Nerve, 2010
In addition, several genes such as CTNNA3, GAB2, PVRL2, TOMM40, and APOC1 are known to be the risk factors that contribute to AD pathogenesis.
Transport of proteins across or into the mitochondrial outer membrane.
Review
Yamano et al., Nagoya, Japan. In Biochim Biophys Acta, 2010
The outer mitochondrial membrane contains two major translocators, the TOM40 (TOM) and TOB/SAM complexes for protein translocation across and/or insertion into the outer membrane.
An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease.
Review
Roses, Durham, United States. In Arch Neurol, 2010
I coauthored a recently published research article describing a variable length, poly-T polymorphism in the TOMM40 gene, adjacent to apolipoprotein E (APOE) on chromosome 19, that accounts for the age at onset distribution for a complex disease, late-onset Alzheimer disease.
A yeast mitochondrial outer membrane protein essential for protein import and cell viability.
Impact
Schatz et al., Basel, Switzerland. In Nature, 1991
The gene encoding ISP42, an integral outermembrane protein located at the yeast mitochondrial protein import site was cloned, sequenced and modified.
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