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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 07 Nov 2015.

TOM40 Tom40p

Tom40, ISP42, TOMM40
TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for protein import into mitochondria (Humphries et al., 2005 [PubMed 15644312]).[supplied by OMIM, May 2008] (from NCBI)
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Top mentioned proteins: apolipoprotein E, AGE, Apolipoprotein C-I, HAD, ACID
Papers on Tom40
Risk prediction for sporadic Alzheimer's disease using genetic risk score in the Han Chinese population.
Wu et al., Shanghai, China. In Oncotarget, 02 Dec 2015
including rs9349407 in CD2AP, rs11218343 in SORL1, rs17125944 in FERMT2, rs6859 in PVRL2, rs157580 and rs2075650 in TOMM40.
Genetic advances in sporadic inclusion body myositis.
Machado et al., London, United Kingdom. In Curr Opin Rheumatol, 30 Nov 2015
The rs10527454 polymorphism in the TOMM40 gene seems to have a disease modifying effect on sIBM by delaying the onset of symptoms, and this effect may be enhanced by the APOE ε3/ε3 genotype.
Structural Neuroimaging Genetics Interactions in Alzheimer's Disease.
Toga et al., Seoul, South Korea. In J Alzheimers Dis, 27 Nov 2015
In the MCI cohort, rs17028008 and rs17027976 were significantly associated with the right caudate and right fusiform gyrus, rs2075650 (TOMM40) was associated with the right caudate, and rs1334496 and rs4829605 were significantly associated with the right inferior temporal gyrus.
Association of genetic variants with dyslipidemia.
Yamada et al., Gifu, Japan. In Mol Med Report, 31 Oct 2015
The χ2 test revealed that rs599839 of proline/serine‑rich coiled‑coil 1 (PSRC1; FDR=0.004) and rs2075650 of translocase of outer mitochondrial membrane 40 homolog (TOMM40; FDR=0.004) were significantly associated with hyper‑LDL‑cholesterolemia. Multivariate logistic regression analysis with adjustment for age, gender and body mass index revealed that rs964184 of ZPR1 (P=5.1x10‑7;
APOE/TOMM40 genetic loci, white matter hyperintensities, and cerebral microbleeds.
Wardlaw et al., Durham, United States. In Int J Stroke, Sep 2015
AIM AND/OR HYPOTHESIS: To test for independent associations between two Alzheimer's disease-susceptibility gene loci - APOE ε and the TOMM40 '523' poly-T repeat - and white matter hyperintensities/cerebral microbleed burden in community-dwelling older adults.
Age-Related Macular Degeneration-Associated Genes in Alzheimer Disease.
Passmore et al., Belfast, United Kingdom. In Am J Geriatr Psychiatry, Jul 2015
MEASUREMENTS: Polymorphisms in the following genes were studied: CFH, ARMS2, C2/CFB, C3, CFI/PLA2G12a, SERPING1, TLR3, TLR4, CRP, APOE, and TOMM40.
Genetic Variants Associated with Lipid Profiles in Chinese Patients with Type 2 Diabetes.
Yang et al., Beijing, China. In Plos One, Dec 2014
Among 4,908 Chinese T2D patients who were not taking lipid-lowering medications, single nucleotide polymorphisms (SNPs) in seven genes previously found to be associated with lipid traits in genome-wide association studies conducted in populations of European ancestry (ABCA1, GCKR, BAZ1B, TOMM40, DOCK7, HNF1A, and HNF4A) were genotyped.
Conservation of Transit Peptide-Independent Protein Import into the Mitochondrial and Hydrogenosomal Matrix.
Gould et al., Düsseldorf, Germany. In Genome Biol Evol, Dec 2014
Though the main translocon of the mitochondrial outer membrane, TOM40, is ubiquitous among organelles of mitochondrial ancestry, the transit peptides, or N-terminal targeting sequences (NTSs), recognised by the TOM complex, are not.
Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort.
Shen et al., Harbin, China. In Biomed Res Int, Dec 2014
The GWAS analysis revealed significant hits within or proximal to APOE, APOC1, and TOMM40 genes, which were previously implicated in AD.
Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers.
Alzheimer’s Disease Neuroimaging Initiative et al., Indianapolis, United States. In Brain Imaging Behav, Jun 2014
Several other genes (e.g., APOC1, FTO, GRIN2B, MAGI2, and TOMM40) were associated with multiple ADNI phenotypes, warranting further investigation on other data sets.
New applications of disease genetics and pharmacogenetics to drug development.
Brannan et al., Durham, United States. In Curr Opin Pharmacol, Feb 2014
The trial is made practical by the use of a pharmacogenetic algorithm based on TOMM40 and APOE genotypes and age to identify normal subjects at high risk of MCI-AD between the ages of 65-83 years within a five year follow-up period.
TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial.
Gottschalk et al., Durham, United States. In Alzheimers Dement, 2013
A number of recent studies have not replicated the association of the translocase of the outer mitochondrial membrane pore subunit (TOMM40) rs10524523 polymorphism, which is in linkage disequilibrium with apolipoprotein E (APOE), with age of onset of Alzheimer's disease (AD).
Downregulation of TOMM40 expression in the blood of Alzheimer disease subjects compared with matched controls.
Krishnan et al., In J Psychiatr Res, 2012
This study demonistrated that Downregulation of TOMM40 expression in the blood of Alzheimer disease.
Levels of cerebrospinal fluid neurofilament light protein in healthy elderly vary as a function of TOMM40 variants.
Blennow et al., United States. In Exp Gerontol, 2012
Subjects with APOE epsilon4 have higher CSF NFL levels than non-epsilon4 carriers, only when they do not carry a short poly-T variant of TOMM40, which is associated with later age of onset of AD
Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE.
Yu et al., Seattle, United States. In J Hum Genet, 2012
The main novel finding of this investigation was that multiple APOE locus cis-elements influence both APOE and TOMM40 promoter activity according to haplotype and cell type.
TOMM40 rs10524523 polymorphism's role in late-onset Alzheimer's disease and in longevity.
Zekanowski et al., Warsaw, Poland. In J Alzheimers Dis, 2011
This study identi fi ed TOMM40alleles, genotypes,as well asTOMM40-E4haplotypes that in fl uencelongevity.
Characterization of the poly-T variant in the TOMM40 gene in diverse populations.
Chiba-Falek et al., Durham, United States. In Plos One, 2011
the poly-T, rs10524523 allele frequencies in different ethnicities.
[Risk factors for Alzheimer's disease].
Yamada et al., Kanazawa, Japan. In Brain Nerve, 2010
In addition, several genes such as CTNNA3, GAB2, PVRL2, TOMM40, and APOC1 are known to be the risk factors that contribute to AD pathogenesis.
An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease.
Roses, Durham, United States. In Arch Neurol, 2010
I coauthored a recently published research article describing a variable length, poly-T polymorphism in the TOMM40 gene, adjacent to apolipoprotein E (APOE) on chromosome 19, that accounts for the age at onset distribution for a complex disease, late-onset Alzheimer disease.
A yeast mitochondrial outer membrane protein essential for protein import and cell viability.
Schatz et al., Basel, Switzerland. In Nature, 1991
The gene encoding ISP42, an integral outermembrane protein located at the yeast mitochondrial protein import site was cloned, sequenced and modified.
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