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proteins. Page last changed on 14 Mar 2013.
TOM40 Tom40p
Tom40, ISP42, TOMM40
TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for protein import into mitochondria (Humphries et al., 2005 [PubMed 15644312]).[supplied by OMIM, May 2008] (from
NCBI)
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Papers on
Tom40
Apolipoprotein E and familial longevity.
New
New York City, United States. In Neurobiol Aging, 30 Apr 2013
The ε4 allele in apolipoprotein E and the linked G allele in rs2075650 of TOMM40 have been associated with increased mortality and the ε2 allele with decreased mortality, although inconsistently.
Chronic Family Stress Moderates the Association between a TOMM40 Variant and Triglyceride Levels in Two Independent Caucasian Samples.
New
In Biol Psychol, 19 Mar 2013
TOMM40 SNP rs157580 has been associated with triglyceride levels in Genome-wide association studies (GWAS).
TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial.
New
Durham, United States. In Alzheimers Dement, 17 Feb 2013
A number of recent studies have not replicated the association of the translocase of the outer mitochondrial membrane pore subunit (TOMM40) rs10524523 polymorphism, which is in linkage disequilibrium with apolipoprotein E (APOE), with age of onset of Alzheimer's disease (AD).
Association of TOMM40 Polymorphisms with Late-Onset Alzheimer's Disease in a Northern Han Chinese Population.
New
Qingdao, China. In Neuromolecular Med, 04 Feb 2013
One interesting candidate gene for mitochondrial dysfunction in LOAD is the translocase of outer mitochondrial membrane 40 homolog (TOMM40) gene.
Genome-wide linkage analysis for human longevity: Genetics of Healthy Ageing Study.
New
Leiden, Netherlands. In Aging Cell, 03 Feb 2013
Using a fixed effect meta-analysis approach, rs4420638 at the TOMM40/APOE/APOC1 gene locus showed significant association with longevity (p-value=9.6 x 10(-8) ).
Gene Expression Profiling of Peripheral Blood Leukocytes Shows Consistent Longitudinal Downregulation of TOMM40 and Upregulation of KIR2DL5A, PLOD1, and SLC2A8 Among Fast Progressors in Early Alzheimer's Disease.
New
Singapore, Singapore. In J Alzheimers Dis, Feb 2013
We previously reported TOMM40 was significantly down-regulated in whole blood of Alzheimer's disease (AD) subjects.
A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing.
New
Edinburgh, United Kingdom. In Mol Psychiatry, Jan 2013
One SNP-rs2075650, located in TOMM40 (translocase of the outer mitochondrial membrane 40 homolog)-had a genome-wide significant association with cognitive ageing (P=2.5 × 10(-8)).
TOMM40 intron 6 poly-T length, age at onset, and neuropathology of AD in individuals with APOE ɛ3/ɛ3.
New
Seattle, United States. In Alzheimers Dement, Dec 2012
BACKGROUND: This study investigates the association between TOMM40 poly-T length, age at onset, and neuropathology in individuals with Alzheimer's disease (AD) with the apolipoprotein E (APOE) ɛ3/ɛ3 allele.
Longitudinal modeling of cognitive aging and the TOMM40 effect.
New
Scottsdale, United States. In Alzheimers Dement, Nov 2012
BACKGROUND: TOMM40 (translocase of the outer mitochondrial membrane pore subunit) is in linkage disequilibrium with apolipoprotein E (APOE).
Improving the resistance of a eukaryotic β-barrel protein to thermal and chemical perturbations.
GeneRIF
Stuttgart, Germany. In J Mol Biol, 2011
The authors propose that the identified weakly stable beta-strands 1, 2 and 9 of human Tom40A play an important role in quaternary protein-protein interactions within the mammalian TOM machinery.
Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease.
GeneRIF
Saint Louis, United States. In Arch Neurol, 2011
No association is found between polyT polymorphisms and TOMM40 gene expression
Functional refolding and characterization of two Tom40 isoforms from human mitochondria.
GeneRIF
Stuttgart, Germany. In J Membr Biol, 2011
Analysis revealed a dominant beta-sheet structure and a short alpha-helical part for both proteins together with a high thermal stability. Two secondary structure elements can be denatured independently
The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype.
GeneRIF
Madison, United States. In Alzheimers Dement, 2011
This study demonistrated taht among APOE epsilon3/epsilon3 late middle-aged adults suggest that a subgroup with VL TOMM40 poly-T lengths may be experiencing incipient LOAD-related cognitive and brain changes.
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
GeneRIF
Brisbane, Australia. In Bmc Med Genet, 2010
variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
[Risk factors for Alzheimer's disease].
Review
Kanazawa, Japan. In Brain Nerve, 2010
In addition, several genes such as CTNNA3, GAB2, PVRL2, TOMM40, and APOC1 are known to be the risk factors that contribute to AD pathogenesis.
Transport of proteins across or into the mitochondrial outer membrane.
Review
Nagoya, Japan. In Biochim Biophys Acta, 2010
The outer mitochondrial membrane contains two major translocators, the TOM40 (TOM) and TOB/SAM complexes for protein translocation across and/or insertion into the outer membrane.
An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease.
Review
Durham, United States. In Arch Neurol, 2010
I coauthored a recently published research article describing a variable length, poly-T polymorphism in the TOMM40 gene, adjacent to apolipoprotein E (APOE) on chromosome 19, that accounts for the age at onset distribution for a complex disease, late-onset Alzheimer disease.
Protein import into mitochondria of Neurospora crassa.
Review
München, Germany. In Fungal Genet Biol, 2002
The translocase of the mitochondrial outer membrane, the TOM complex, comprises receptors which specifically recognize mitochondrial preproteins and a protein conducting channel formed by TOM40.
A yeast mitochondrial outer membrane protein essential for protein import and cell viability.
Impact
Basel, Switzerland. In Nature, 1991
The gene encoding ISP42, an integral outermembrane protein located at the yeast mitochondrial protein import site was cloned, sequenced and modified.
Mitochondrial protein import.
Review
Marseille, France. In J Bioenerg Biomembr, 1990
In yeast, a 42-kilodalton protein (ISP42) probably forms part of the outer membrane channel.
