Evaluation of late-onset Alzheimer disease genetic susceptibility risks in a Canadian population.
Vancouver, Canada. In Neurobiol Aging, 30 Apr 2014
Our prevalent case study comparing prevalent AD cases (n = 428) with participants with no cognitive impairment (n = 524) revealed a significant association of rs6656401 and rs3818361 (CR1), rs2075650 (TOMM40), rs7561528 (BIN1), and rs3865444 (CD33) with late-onset AD that were robust to adjustment with age and apolipoprotein E ε4 genotype.
Structural insights into proapoptotic signaling mediated by MTCH2, VDAC2, TOM40 and TOM22.
Minsk, Belarus. In Cell Signal, 28 Feb 2014
Shortly thereafter, several MOM proteins, such as VDAC2, MTCH2, TOM22 and TOM40, have been identified as the Bax, Bak and tBid receptors that are indispensable in MOMP, but the underlying mechanisms are elusive.
[Risk factors for Alzheimer's disease].
Kanazawa, Japan. In Brain Nerve, 2010
In addition, several genes such as CTNNA3, GAB2, PVRL2, TOMM40, and APOC1 are known to be the risk factors that contribute to AD pathogenesis.
An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease.
Durham, United States. In Arch Neurol, 2010
I coauthored a recently published research article describing a variable length, poly-T polymorphism in the TOMM40 gene, adjacent to apolipoprotein E (APOE) on chromosome 19, that accounts for the age at onset distribution for a complex disease, late-onset Alzheimer disease.
Protein import into mitochondria of Neurospora crassa.
München, Germany. In Fungal Genet Biol, 2002
The translocase of the mitochondrial outer membrane, the TOM complex, comprises receptors which specifically recognize mitochondrial preproteins and a protein conducting channel formed by TOM40.