Genetic advances in sporadic inclusion body myositis.
London, United Kingdom. In Curr Opin Rheumatol, Nov 2015
The rs10527454 polymorphism in the TOMM40 gene seems to have a disease modifying effect on sIBM by delaying the onset of symptoms, and this effect may be enhanced by the APOE ε3/ε3 genotype.
Structural Neuroimaging Genetics Interactions in Alzheimer's Disease.
Seoul, South Korea. In J Alzheimers Dis, Nov 2015
In the MCI cohort, rs17028008 and rs17027976 were significantly associated with the right caudate and right fusiform gyrus, rs2075650 (TOMM40) was associated with the right caudate, and rs1334496 and rs4829605 were significantly associated with the right inferior temporal gyrus.
Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China.
Changsha, China. In Plos One, 2014
Risk SNPs included rs9331888 (CLU), rs6691117 (CR1), rs4938933 (MS4A), rs9349407 (CD2AP), rs1160985 (TOMM40), rs4945261 (GAB2) and rs5984894 (PCDH11X); Protective SNPs consisted of rs744373 (BIN1), rs1562990 (MS4A), rs597668 (EXOC3L2), rs9271192 (HLA-DRB5/DRB1), rs157581 and rs11556505 (TOMM40).