Genetic advances in sporadic inclusion body myositis.
London, United Kingdom. In Curr Opin Rheumatol, 01 Oct 2015
The rs10527454 polymorphism in the TOMM40 gene seems to have a disease modifying effect on sIBM by delaying the onset of symptoms, and this effect may be enhanced by the APOE ε3/ε3 genotype.
Association of genetic variants with dyslipidemia.
Gifu, Japan. In Mol Med Report, 16 Aug 2015
The χ2 test revealed that rs599839 of proline/serine‑rich coiled‑coil 1 (PSRC1; FDR=0.004) and rs2075650 of translocase of outer mitochondrial membrane 40 homolog (TOMM40; FDR=0.004) were significantly associated with hyper‑LDL‑cholesterolemia. Multivariate logistic regression analysis with adjustment for age, gender and body mass index revealed that rs964184 of ZPR1 (P=5.1x10‑7;
Stimulatory Effects of Balanced Deep Sea Water on Mitochondrial Biogenesis and Function.
Taegu, South Korea. In Plos One, Dec 2014
Quantitative real-time PCR revealed that BDSW enhances gene expression of PGC-1α, NRF1, and TFAM for mitochondrial transcription; MFN1/2 and DRP1 for mitochondrial fusion; OPA1 for mitochondrial fission; TOMM40 and TIMM44 for mitochondrial protein import; CPT-1α and MCAD for fatty acid oxidation; CYTC for oxidative phosphorylation.
Genetic Variants Associated with Lipid Profiles in Chinese Patients with Type 2 Diabetes.
Beijing, China. In Plos One, Dec 2014
Among 4,908 Chinese T2D patients who were not taking lipid-lowering medications, single nucleotide polymorphisms (SNPs) in seven genes previously found to be associated with lipid traits in genome-wide association studies conducted in populations of European ancestry (ABCA1, GCKR, BAZ1B, TOMM40, DOCK7, HNF1A, and HNF4A) were genotyped.
[Risk factors for Alzheimer's disease].
Kanazawa, Japan. In Brain Nerve, 2010
In addition, several genes such as CTNNA3, GAB2, PVRL2, TOMM40, and APOC1 are known to be the risk factors that contribute to AD pathogenesis.
An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease.
Durham, United States. In Arch Neurol, 2010
I coauthored a recently published research article describing a variable length, poly-T polymorphism in the TOMM40 gene, adjacent to apolipoprotein E (APOE) on chromosome 19, that accounts for the age at onset distribution for a complex disease, late-onset Alzheimer disease.