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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Oct 2014.

TOM40 Tom40p

Tom40, ISP42, TOMM40
TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for protein import into mitochondria (Humphries et al., 2005 [PubMed 15644312]).[supplied by OMIM, May 2008] (from NCBI)
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Top mentioned proteins: apolipoprotein E, AGE, Apolipoprotein C-I, HAD, Tom22
Papers on Tom40
Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study.
New
Tanaka et al., In Lipids Health Dis, 14 Nov 2014
RESULTS: Logistic regression analysis revealed that SNPs APOA5 T - 1131C (rs662799), APOA5 T1259C (rs2266788), TOMM40 A/G (rs157580), and CETP TaqIB (rs708272) were significantly associated with CKD risk in those individuals genotyped, with age- and sex-adjusted odds ratios (ORs) per minor allele (and 95% confidence intervals (CIs)) of OR 1.22 (95% CI:1.06-1.39),
No evidence of association between variant rs2075650 in lipid metabolism-related locus APOE/TOMM40 and advanced age-related macular degeneration in Han Chinese population.
New
Liu et al., Shanghai, China. In Exp Biol Med (maywood), 10 Nov 2014
Recently, a variant rs2075650 located in lipid metabolism-related locus APOE/TOMM40 was identified to be associated with advanced AMD and early AMD, respectively, in two genome-wide association studies with European ancestry, while no association study between rs2075650 and overall advanced AMD in Chinese population has been conducted before.
Expression of the Bcl-2 family genes and complexes involved in the mitochondrial transport in prostate cancer cells.
New
Hinsch et al., In Int J Oncol, 31 Oct 2014
We investigated the expression of genes of the Bcl-2 family, i.e., pro-apoptotic Bak and Bid, and anti-apoptotic Bcl-2; VDAC gene, i.e., VDAC1, VDAC2 and VDAC3; and TOMM genes, i.e., TOMM20, TOMM22 and TOMM40.
African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles.
New
Welsh-Bohmer et al., Durham, United States. In Alzheimers Dement, 23 Oct 2014
METHODS: We have compared the APOE and TOMM40'523 phased haplotype frequencies of a 9.5 kb TOMM40/APOE genomic region in West African, Caucasian, and African-American cohorts.
TOMM40 Alterations in Alzheimer's Disease Over a 2-Year Follow-Up Period.
New
Chong et al., Singapore, Singapore. In J Alzheimers Dis, 08 Oct 2014
UNLABELLED: We previously reported TOMM40 to be significantly down-regulated in whole blood of Alzheimer's disease (AD) subjects at baseline and after one-year.
Association of Exome Sequences with Plasma C-reactive Protein Levels in >9,000 Participants.
New
on Behalf of the Cohorts for Heart and Aging Research in Genomic Epidemiology and the National Heart et al., Seattle, United States. In Hum Mol Genet, 03 Oct 2014
we confirmed associations for reported common variants of HNF1A, CRP, IL6R, and TOMM40-APOE.
The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes.
New
Beeri et al., Ramat Gan, Israel. In Eur Neuropsychopharmacol, 30 Sep 2014
The variable length poly-T, rs10524523 ('523') located within the TOMM40 gene, was recently associated with several phenotypes of cognitive function.
New applications of disease genetics and pharmacogenetics to drug development.
Review
New
Brannan et al., Durham, United States. In Curr Opin Pharmacol, Feb 2014
The trial is made practical by the use of a pharmacogenetic algorithm based on TOMM40 and APOE genotypes and age to identify normal subjects at high risk of MCI-AD between the ages of 65-83 years within a five year follow-up period.
Longitudinal analysis is more powerful than cross-sectional analysis in detecting genetic association with neuroimaging phenotypes.
New
Alzheimer's Disease Neuroimaging Initiative et al., Minneapolis, United States. In Plos One, Dec 2013
In particular, at the genome-wide significance level, both SNP rs429358 in gene APOE and SNP rs2075650 in gene TOMM40 were confirmed to be associated with various imaging phenotypes in multiple regions of interests (ROIs) by both analyses, though longitudinal analysis detected more regional phenotypes associated with the two SNPs and indicated another significant SNP rs439401 in gene APOE.
Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?
New
Deary et al., Edinburgh, United Kingdom. In Transl Psychiatry, Dec 2013
Genetic polymorphisms in the APOE ɛ and TOMM40 '523' poly-T repeat gene loci have been associated with significantly increased risk of Alzheimer's disease.
TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial.
Review
New
Gottschalk et al., Durham, United States. In Alzheimers Dement, Mar 2013
A number of recent studies have not replicated the association of the translocase of the outer mitochondrial membrane pore subunit (TOMM40) rs10524523 polymorphism, which is in linkage disequilibrium with apolipoprotein E (APOE), with age of onset of Alzheimer's disease (AD).
Downregulation of TOMM40 expression in the blood of Alzheimer disease subjects compared with matched controls.
GeneRIF
Krishnan et al., In J Psychiatr Res, 2012
This study demonistrated that Downregulation of TOMM40 expression in the blood of Alzheimer disease.
Levels of cerebrospinal fluid neurofilament light protein in healthy elderly vary as a function of TOMM40 variants.
GeneRIF
Blennow et al., United States. In Exp Gerontol, 2012
Subjects with APOE epsilon4 have higher CSF NFL levels than non-epsilon4 carriers, only when they do not carry a short poly-T variant of TOMM40, which is associated with later age of onset of AD
Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE.
GeneRIF
Yu et al., Seattle, United States. In J Hum Genet, 2012
The main novel finding of this investigation was that multiple APOE locus cis-elements influence both APOE and TOMM40 promoter activity according to haplotype and cell type.
TOMM40 rs10524523 polymorphism's role in late-onset Alzheimer's disease and in longevity.
GeneRIF
Zekanowski et al., Warsaw, Poland. In J Alzheimers Dis, 2011
This study identi fi ed TOMM40alleles, genotypes,as well asTOMM40-E4haplotypes that in fl uencelongevity.
Characterization of the poly-T variant in the TOMM40 gene in diverse populations.
GeneRIF
Chiba-Falek et al., Durham, United States. In Plos One, 2011
the poly-T, rs10524523 allele frequencies in different ethnicities.
[Risk factors for Alzheimer's disease].
Review
Yamada et al., Kanazawa, Japan. In Brain Nerve, 2010
In addition, several genes such as CTNNA3, GAB2, PVRL2, TOMM40, and APOC1 are known to be the risk factors that contribute to AD pathogenesis.
Transport of proteins across or into the mitochondrial outer membrane.
Review
Yamano et al., Nagoya, Japan. In Biochim Biophys Acta, 2010
The outer mitochondrial membrane contains two major translocators, the TOM40 (TOM) and TOB/SAM complexes for protein translocation across and/or insertion into the outer membrane.
An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease.
Review
Roses, Durham, United States. In Arch Neurol, 2010
I coauthored a recently published research article describing a variable length, poly-T polymorphism in the TOMM40 gene, adjacent to apolipoprotein E (APOE) on chromosome 19, that accounts for the age at onset distribution for a complex disease, late-onset Alzheimer disease.
A yeast mitochondrial outer membrane protein essential for protein import and cell viability.
Impact
Schatz et al., Basel, Switzerland. In Nature, 1991
The gene encoding ISP42, an integral outermembrane protein located at the yeast mitochondrial protein import site was cloned, sequenced and modified.
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